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Identification of NKIAMRE, the Human Homologue to the Mitogen-activated Protein Kinase-/Cyclin-dependent Kinase-related Protein Kinase NKIATRE, and Its Loss in Leukemic Blasts with Chromosome Arm 5q Deletion¹

Departments of Medical Biophysics [M. M., J. A. S., B. W. Z.], Medicine [B. W. Z.], and Laboratory Medicine and Pathobiology [J. A. S.] and Institute of Medical Sciences [R. H., B. W. Z.], University of Toronto, and The Ontario Cancer Institute/Princess Margaret Hospital [M. M., R. H., J. A. S., B. W. Z.], Toronto, Ontario, Canada, M5G 2M9

Human acute leukemia and myelodysplasia are often associated with an interstitial deletion in chromosome arm 5q. The deleted region is hypothesized to contain tumor suppressor loci that are critical to the maintenance of normal hematopoiesis. We have identified NKIAMRE, a novel cyclin-dependent kinase-related molecule that is closely related to the rat serine/threonine kinase NKIATRE. Human NKIAMRE localizes to chromosome band 5q31.1, centromeric to the interleukin 9 locus and telomeric to IFN response factor-1. NKIAMRE was deleted at both alleles in 9 of 18 leukemic samples with chromosome band 5q31 abnormalities studied by fluorescence in situ chromosomal hybridization. NKIAMRE loss may be an important determinant of dysmyelopoiesis.