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[Cancer Research 59, 4175-4179, September 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 4175-4179, September 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Telomerase-negative Immortalized Human Cells Contain a Novel Type of Promyelocytic Leukemia (PML) Body1

Thomas R. Yeager, Axel A. Neumann, Anna Englezou, Lily I. Huschtscha, Jane R. Noble and Roger R. Reddel2

Children’s Medical Research Institute, Westmead, Sydney, New South Wales 2145, Australia

Telomerase-negative immortalized human cells maintain their telomeres by a mechanism known as alternative lengthening of telomeres (ALT). We report here that ALT cells contain a novel promyelocytic leukemia (PML) body (ALT-associated PML body, APB). APBs are large donut-shaped nuclear structures containing PML protein, telomeric DNA, and the telomere binding proteins human telomere repeat binding factors 1 and 2. Immunostaining showed that APBs also contain replication factor A, RAD51, and RAD52, proteins involved in DNA synthesis and recombination. During immortalization, APBs appeared at exactly the same time as activation of ALT. APBs were found in ALT tumors and cell lines but not in mortal cell strains or in telomerase-positive cell lines or tumors.




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