Cancer Research Versailles No Abst Frontiers in Basic Cancer Research
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[Cancer Research 59, 4219-4221, September 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 4219-4221, September 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Heat Shock Cognate 70 Mutations in Sporadic Breast Carcinoma1

Christopher J. Bakkenist2,,3, John Koreth2, Cory S. M. Williams, Nicholas C. A. Hunt and James O. McGee

University of Oxford, Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom

Heat Shock Cognate 70 (HSC70) is a constitutively expressed molecular chaperone, functions of which regulate the structure, subcellular localization, and turnover of cell proteins. It is also a component of the centrosome facilitating rearrangements during mitotic/meiotic spindle formation and cytoplasmic microtubule organization. We localized HSC70 to 11q23.3, a region deleted in 40% of sporadic breast and other cancers. Sequencing demonstrated mutation in the NH2-terminal ATPase domain of HSC70 in 2 of 15 sporadic breast carcinomas examined. In both cases, mutation was coincident with allelic imbalance, suggesting that HSC70 is a target of somatic mutation and deletion in a fraction of breast carcinomas.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.