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[Cancer Research 59, 4228-4232, September 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 4228-4232, September 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Reactivation of Insulin-like Growth Factor Binding Protein 2 Expression in Glioblastoma Multiforme

A Revelation by Parallel Gene Expression Profiling1

Gregory N. Fuller2, Chang Hun Rhee2,,3, Kenneth R. Hess, Laura S. Caskey, Ruoping Wang, Janet M. Bruner, W. K. Alfred Yung and Wei Zhang4

Departments of Pathology [G. N. F., J. M. B., L. S. C., W. Z.], Neuro-Oncology [C. H. R., L. S. C., R. W., W. K. A. Y., W. Z.], and Biomathematics [K. R. H.], University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

We carried out a gene expression profiling study using cDNA array technology with 24 primary glioma tissues of low-grade (oligodendroglioma), intermediate-grade (anaplastic oligodendroglioma and anaplastic astrocytoma), and high-grade (glioblastomas multiforme) tumors and found that insulin-like growth factor binding protein 2 (IGFBP2) was consistently overexpressed only in glioblastoma multiforme. The cDNA array results were confirmed by Northern and Western blotting. The fact that the IGFBP2 gene, which is normally expressed in fetal cells and turned off in adult cells, becomes reactivated in the most advanced stage of glioma suggests that glioma progression is a result of dedifferentiation or results from a block of differentiation. Identification of IGFBP2 as a gene associated with glioma progression demonstrates the power and utility of high-throughput gene expression profiling in cancer gene discovery.




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Copyright © 1999 by the American Association for Cancer Research.