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[Cancer Research 59, 4242-4246, September 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 4242-4246, September 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

A Single Targeted Ets2 Allele Restricts Development of Mammary Tumors in Transgenic Mice1

Nickolay Neznanov2, Albert K. Man, Hideyuki Yamamoto, Craig A. Hauser, Robert D. Cardiff and Robert G. Oshima2,,3

The Burnham Institute, La Jolla, California 92037 [N. N., A. K. M., H. Y., C. A. H., R. G. O.]; and Department of Pathology, School of Medicine University of California at Davis, Davis, California 95616 [R. D. C.]

Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one-half the size of tumors from controls. The smaller size of the tumors was correlated with a more differentiated state of early hyperplastic growths and not to differential growth of the frank tumors or to decreased middle T gene expression. Ets2 may regulate the progression of these aggressive mammary tumors.




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Copyright © 1999 by the American Association for Cancer Research.