| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Clinical Investigations |
Departments of Pathology [M. E. M.] and Radiation Oncology [I. K.], Beth Israel Deaconess Medical Center, Department of Pathology, Brigham and Women’s Hospital [M. L.], and the Department of Adult Oncology and the Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute [P. S., S. P., M. L., W. R. S.], Harvard Medical School, Boston, Massachusetts 02115
The tumor suppressor gene PTEN/MMAC-1/TEP-1 (referred to hereafter as PTEN) maps to chromosome 10q23 and encodes a dual specificity phosphatase. The PTEN protein negatively regulates cell migration and cell survival and induces a G1 cell cycle block via negative regulation of the phosphatidylinositol 3'-kinase/protein kinase B/Akt signaling pathway. PTEN is frequently mutated or deleted in both prostate cancer cell lines and primary prostate cancers. A murine polyclonal antiserum was raised against a glutathione S-transferase fusion polypeptide of the COOH terminus of PTEN. Archival paraffin tissue sections from 109 cases of resected prostate cancer were immunostained with the antiserum, using DU145 and PC-3 cells as positive and negative controls, respectively. PTEN expression was seen in the secretory cells. Cases were considered positive when granular cytoplasmic staining was seen in all tumor cells, mixed when areas of both positive and negative tumor cell clones were seen, and negative when adjacent benign prostate tissue but not tumor tissue showed positive staining. Seventeen cases (15.6%) of prostate cancer were positive, 70 cases (64.2%) were mixed, and 22 cases (20.2%) were negative. Total absence of PTEN expression correlated with the Gleason score (P = 0.0081) and correlated more significantly with a Gleason score of 7 or higher (P = 0.0004) and with advanced pathological stage (American Joint Committee on Cancer stages T3b and T4; P = 0.0078). Thus, loss of PTEN protein is correlated with pathological markers of poor prognosis in prostate cancer.
This article has been cited by other articles:
|
|
 |
|
  O. C. Rodriguez, E. W. Lai, S. Vissapragada, C. Cromelin, M. Avetian, P. Salinas, H. Ramos, B. Kallakury, M. Casimiro, M. P. Lisanti, et al. A Reduction in Pten Tumor Suppressor Activity Promotes ErbB-2-Induced Mouse Prostate Adenocarcinoma Formation through the Activation of Signaling Cascades Downstream of PDK1 Am. J. Pathol., June 1, 2009; 174(6): 2051 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.-q. Chen, Q.-k. Yang, B.-w. Lu, W. Yi, G. Cantin, Y.-l. Chen, C. Fearns, J. R. Yates III, and J.-D. Lee CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells Cancer Res., March 15, 2009; 69(6): 2663 - 2668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Norris, M. Gentry, D. M. Peehl, R. D'Agostino Jr., and K. D. Scarpinato The Elevated Expression of a Mismatch Repair Protein Is a Predictor for Biochemical Recurrence After Radical Prostatectomy Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 57 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. T. Coleman, R. Bigelow, and J. A. Cardelli Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation Mol. Cancer Ther., January 1, 2009; 8(1): 214 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ader, L. Brizuela, P. Bouquerel, B. Malavaud, and O. Cuvillier Sphingosine Kinase 1: A New Modulator of Hypoxia Inducible Factor 1{alpha} during Hypoxia in Human Cancer Cells Cancer Res., October 15, 2008; 68(20): 8635 - 8642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tomioka, M. Tanaka, M. A. De Velasco, S. Anai, S. Takada, T. Kushibiki, Y. Tabata, C. J. Rosser, H. Uemura, and Y. Hirao Delivery of PTEN via a novel gene microcapsule sensitizes prostate cancer cells to irradiation Mol. Cancer Ther., July 1, 2008; 7(7): 1864 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Shen and C. Abate-Shen Pten Inactivation and the Emergence of Androgen-Independent Prostate Cancer Cancer Res., July 15, 2007; 67(14): 6535 - 6538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z Wu, K. McRoberts, and D Theodorescu The role of PTEN in prostate cancer cell tropism to the bone micro-environment Carcinogenesis, July 1, 2007; 28(7): 1393 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bedolla, T. J. Prihoda, J. I. Kreisberg, S. N. Malik, N. K. Krishnegowda, D. A. Troyer, and P. M. Ghosh Determining Risk of Biochemical Recurrence in Prostate Cancer by Immunohistochemical Detection of PTEN Expression and Akt Activation Clin. Cancer Res., July 1, 2007; 13(13): 3860 - 3867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Edick, L. Tesfay, L. E. Lamb, B. S. Knudsen, and C. K. Miranti Inhibition of Integrin-mediated Crosstalk with Epidermal Growth Factor Receptor/Erk or Src Signaling Pathways in Autophagic Prostate Epithelial Cells Induces Caspase-independent Death Mol. Biol. Cell, July 1, 2007; 18(7): 2481 - 2490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Fan, T. Yanase, H. Morinaga, T. Okabe, M. Nomura, H. Daitoku, A. Fukamizu, S. Kato, R. Takayanagi, and H. Nawata Insulin-like Growth Factor 1/Insulin Signaling Activates Androgen Signaling through Direct Interactions of Foxo1 with Androgen Receptor J. Biol. Chem., March 9, 2007; 282(10): 7329 - 7338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhou, L.-Z. Liu, B. Fu, X. Hu, X. Shi, J. Fang, and B.-H. Jiang Reactive oxygen species regulate insulin-induced VEGF and HIF-1{alpha} expression through the activation of p70S6K1 in human prostate cancer cells Carcinogenesis, January 1, 2007; 28(1): 28 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J Burd, L. M Morey, and K. E Knudsen Androgen receptor corepressors and prostate cancer Endocr. Relat. Cancer, December 1, 2006; 13(4): 979 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Riedemann and V M Macaulay IGF1R signalling and its inhibition Endocr. Relat. Cancer, December 1, 2006; 13(Supplement_1): S33 - S43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cao, T. Subhawong, J. M. Albert, K. W. Kim, L. Geng, K. R. Sekhar, Y. J. Gi, and B. Lu Inhibition of Mammalian Target of Rapamycin or Apoptotic Pathway Induces Autophagy and Radiosensitizes PTEN Null Prostate Cancer Cells. Cancer Res., October 15, 2006; 66(20): 10040 - 10047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. R. Sastry, Y. Karpova, and G. Kulik Epidermal Growth Factor Protects Prostate Cancer Cells from Apoptosis by Inducing BAD Phosphorylation via Redundant Signaling Pathways J. Biol. Chem., September 15, 2006; 281(37): 27367 - 27377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gao, X. Ouyang, W. A. Banach-Petrosky, M. M. Shen, and C. Abate-Shen Emergence of Androgen Independence at Early Stages of Prostate Cancer Progression in Nkx3.1; Pten Mice Cancer Res., August 15, 2006; 66(16): 7929 - 7933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yuan, T. Li, H. Wang, T. Zhang, M. Barua, R. A. Borgesi, G. J. Bubley, M. L. Lu, and S. P. Balk Androgen Receptor Remains Critical for Cell-Cycle Progression in Androgen-Independent CWR22 Prostate Cancer Cells Am. J. Pathol., August 1, 2006; 169(2): 682 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Nie, S. Krishnamoorthy, R. Jin, K. Tang, Y. Chen, Y. Qiao, A. Zacharek, Y. Guo, J. Milanini, G. Pages, et al. Mechanisms Regulating Tumor Angiogenesis by 12-Lipoxygenase in Prostate Cancer Cells J. Biol. Chem., July 7, 2006; 281(27): 18601 - 18609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bertram, J. W. Peacock, C. Tan, A. L-F. Mui, S. W. Chung, M. E. Gleave, S. Dedhar, M. E. Cox, and C. J. Ong Inhibition of the Phosphatidylinositol 3'-Kinase Pathway Promotes Autocrine Fas-Induced Death of Phosphatase and Tensin Homologue-Deficient Prostate Cancer Cells. Cancer Res., May 1, 2006; 66(9): 4781 - 4788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vijayakumar, D. C. Hall, X. T. Reveles, D. A. Troyer, I. M. Thompson, D. Garcia, R. Xiang, R. J. Leach, T. L. Johnson-Pais, and S. L. Naylor Detection of Recurrent Copy Number Loss at Yp11.2 Involving TSPY Gene Cluster in Prostate Cancer Using Array-Based Comparative Genomic Hybridization. Cancer Res., April 15, 2006; 66(8): 4055 - 4064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wu, K. Zu, M. A. Warren, P. K. Wallace, and C. Ip Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells. Mol. Cancer Ther., February 1, 2006; 5(2): 246 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Abdel-Rahman, Y. Yang, X.-P. Zhou, E. L. Craig, F. H. Davidorf, and C. Eng High Frequency of Submicroscopic Hemizygous Deletion Is a Major Mechanism of Loss of Expression of PTEN in Uveal Melanoma J. Clin. Oncol., January 10, 2006; 24(2): 288 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hill, Y. Song, R. D. Cardiff, and T. Van Dyke Heterogeneous Tumor Evolution Initiated by Loss of pRb Function in a Preclinical Prostate Cancer Model Cancer Res., November 15, 2005; 65(22): 10243 - 10254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Nelson, H. Cao, Y. Zhu, B. Sunar-Reeder, C. Y.H. Choi, J. D. Faix, J. M. Brown, A. C. Koong, A. J. Giaccia, and Q.-T. Le A Noninvasive Approach for Assessing Tumor Hypoxia in Xenografts: Developing a Urinary Marker for Hypoxia Cancer Res., July 15, 2005; 65(14): 6151 - 6158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Ma, A. C. Ziel-van der Made, B. Autar, H. A. van der Korput, M. Vermeij, P. van Duijn, K. B. Cleutjens, R. de Krijger, P. Krimpenfort, A. Berns, et al. Targeted Biallelic Inactivation of Pten in the Mouse Prostate Leads to Prostate Cancer Accompanied by Increased Epithelial Cell Proliferation but not by Reduced Apoptosis Cancer Res., July 1, 2005; 65(13): 5730 - 5739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Hughes, A Murphy, C Martin, O Sheils, and J O'Leary Molecular pathology of prostate cancer J. Clin. Pathol., July 1, 2005; 58(7): 673 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z Culig, H Steiner, G Bartsch, and A Hobisch Mechanisms of endocrine therapy-responsive and -unresponsive prostate tumours Endocr. Relat. Cancer, June 1, 2005; 12(2): 229 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. E. Grizzle, D. G. Bostwick, H. Burke, O. W. Tawfik, D. McGregor, J. Cohn, and R. Lieberman Biomarkers in Prostate Cancer Am. Assoc. Cancer Res. Educ. Book, April 1, 2005; 2005(1): 196 - 204. [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Lynch, B. W. Konicek, A. M. McNulty, K. R. Hanna, J. E. Lewis, B. L. Neubauer, and J. R. Graff The Progression of LNCaP Human Prostate Cancer Cells to Androgen Independence Involves Decreased FOXO3a Expression and Reduced p27KIP1 Promoter Transactivation Mol. Cancer Res., March 1, 2005; 3(3): 163 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. V. Thomas, S. Horvath, B. L. Smith, K. Crosby, L. A. Lebel, M. Schrage, J. Said, J. De Kernion, R. E. Reiter, and C. L. Sawyers Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer Clin. Cancer Res., December 15, 2004; 10(24): 8351 - 8356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Beer, A. Myrthue, M. Garzotto, M. F. O'Hara, R. Chin, B. A. Lowe, M. A. Montalto, C. L. Corless, and W. D. Henner Randomized Study of High-Dose Pulse Calcitriol or Placebo prior to Radical Prostatectomy Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2225 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Foley, D. Hollywood, and M. Lawler Molecular pathology of prostate cancer: the key to identifying new biomarkers of disease Endocr. Relat. Cancer, September 1, 2004; 11(3): 477 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kraus, G. Levy, T. Hanoch, Z. Naor, and R. Seger Gonadotropin-Releasing Hormone Induces Apoptosis of Prostate Cancer Cells: Role of c-Jun NH2-Terminal Kinase, Protein Kinase B, and Extracellular Signal-Regulated Kinase Pathways Cancer Res., August 15, 2004; 64(16): 5736 - 5744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Dasmahapatra, P. Didolkar, M. C. Alley, S. Ghosh, E. A. Sausville, and K. K. Roy In vitro Combination Treatment with Perifosine and UCN-01 Demonstrates Synergism against Prostate (PC-3) and Lung (A549) Epithelial Adenocarcinoma Cell Lines Clin. Cancer Res., August 1, 2004; 10(15): 5242 - 5252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Sansal and W. R. Sellers The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway J. Clin. Oncol., July 15, 2004; 22(14): 2954 - 2963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Huang, D. C. Muddiman, and D. J. Tindall Androgens Negatively Regulate Forkhead Transcription Factor FKHR (FOXO1) through a Proteolytic Mechanism in Prostate Cancer Cells J. Biol. Chem., April 2, 2004; 279(14): 13866 - 13877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Heinlein and C. Chang Androgen Receptor in Prostate Cancer Endocr. Rev., April 1, 2004; 25(2): 276 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Kondapaka, S. S. Singh, G. P. Dasmahapatra, E. A. Sausville, and K. K. Roy Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation Mol. Cancer Ther., November 1, 2003; 2(11): 1093 - 1103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tanaka, M. V. Gavrielides, Y. Mitsuuchi, T. Fujii, and M. G. Kazanietz Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway J. Biol. Chem., September 5, 2003; 278(36): 33753 - 33762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rossi, E. Graner, P. Febbo, L. Weinstein, N. Bhattacharya, T. Onody, G. Bubley, S. Balk, and M. Loda Fatty Acid Synthase Expression Defines Distinct Molecular Signatures in Prostate Cancer Mol. Cancer Res., August 1, 2003; 1(10): 707 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. G. Nelson, A. M. De Marzo, and W. B. Isaacs Prostate Cancer N. Engl. J. Med., July 24, 2003; 349(4): 366 - 381. [Full Text] [PDF]
|
|
|
|
|
|
C. Abate-Shen, W. A. Banach-Petrosky, X. Sun, K. D. Economides, N. Desai, J. P. Gregg, A. D. Borowsky, R. D. Cardiff, and M. M. Shen Nkx3.1; Pten Mutant Mice Develop Invasive Prostate Adenocarcinoma and Lymph Node Metastases Cancer Res., July 15, 2003; 63(14): 3886 - 3890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-T. Le and A. J. Giaccia HIF-{alpha}, a Gender Independent Transcription Factor Clin. Cancer Res., July 1, 2003; 9(7): 2391 - 2393. [Full Text] [PDF]
|
|
|
|
|
|
O. J. Halvorsen, S. A. Haukaas, and L. A. Akslen Combined Loss of PTEN and p27 Expression Is Associated with Tumor Cell Proliferation by Ki-67 and Increased Risk of Recurrent Disease in Localized Prostate Cancer Clin. Cancer Res., April 1, 2003; 9(4): 1474 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Modur, R. Nagarajan, B. M. Evers, and J. Milbrandt FOXO Proteins Regulate Tumor Necrosis Factor-related Apoptosis Inducing Ligand Expression. IMPLICATIONS FOR PTEN MUTATION IN PROSTATE CANCER J. Biol. Chem., November 27, 2002; 277(49): 47928 - 47937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Grunwald, L. DeGraffenried, D. Russel, W. E. Friedrichs, R. B. Ray, and M. Hidalgo Inhibitors of mTOR Reverse Doxorubicin Resistance Conferred by PTEN Status in Prostate Cancer Cells Cancer Res., November 1, 2002; 62(21): 6141 - 6145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Rebbeck Inherited Genotype and Prostate Cancer Outcomes Cancer Epidemiol. Biomarkers Prev., October 1, 2002; 11(10): 945 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fernandez and C. Eng The Expanding Role of PTEN in Neoplasia: A Molecule for All Seasons? : Commentary re: M. A. Davies, et al., Adenoviral-mediated Expression of MMAC/PTEN Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells. Clin. Cancer Res., 8: 1904-1914, 2002. Clin. Cancer Res., June 1, 2002; 8(6): 1695 - 1698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Davies, S. J. Kim, N. U. Parikh, Z. Dong, C. D. Bucana, and G. E. Gallick Adenoviral-mediated Expression of MMAC/PTEN Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells Clin. Cancer Res., June 1, 2002; 8(6): 1904 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. O. Hellawell, G. D. H. Turner, D. R. Davies, R. Poulsom, S. F. Brewster, and V. M. Macaulay Expression of the Type 1 Insulin-like Growth Factor Receptor Is Up-Regulated in Primary Prostate Cancer and Commonly Persists in Metastatic Disease Cancer Res., May 1, 2002; 62(10): 2942 - 2950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhuang, J. Lin, M. L. Lu, K. R. Solomon, and M. R. Freeman Cholesterol-rich Lipid Rafts Mediate Akt-regulated Survival in Prostate Cancer Cells Cancer Res., April 1, 2002; 62(8): 2227 - 2231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Malik, M. Brattain, P. M. Ghosh, D. A. Troyer, T. Prihoda, R. Bedolla, and J. I. Kreisberg Immunohistochemical Demonstration of Phospho-Akt in High Gleason Grade Prostate Cancer Clin. Cancer Res., April 1, 2002; 8(4): 1168 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Chinni and F. H. Sarkar Akt Inactivation Is a Key Event in Indole-3-carbinol-induced Apoptosis in PC-3 Cells Clin. Cancer Res., April 1, 2002; 8(4): 1228 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Konishi, M. Nakamura, M. Kishi, M. Nishimine, E. Ishida, and K. Shimada Heterogeneous Methylation and Deletion Patterns of the INK4a/ARF Locus Within Prostate Carcinomas Am. J. Pathol., April 1, 2002; 160(4): 1207 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Grossmann, H. Huang, and D. J. Tindall Androgen Receptor Signaling in Androgen-Refractory Prostate Cancer J Natl Cancer Inst, November 21, 2001; 93(22): 1687 - 1697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Huang, J. C. Cheville, Y. Pan, P. C. Roche, L. J. Schmidt, and D. J. Tindall PTEN Induces Chemosensitivity in PTEN-mutated Prostate Cancer Cells by Suppression of Bcl-2 Expression J. Biol. Chem., October 12, 2001; 276(42): 38830 - 38836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Minaguchi, H. Yoshikawa, K. Oda, T. Ishino, T. Yasugi, T. Onda, S. Nakagawa, K. Matsumoto, K. Kawana, and Y. Taketani PTEN Mutation Located Only Outside Exons 5, 6, and 7 Is an Independent Predictor of Favorable Survival in Endometrial Carcinomas Clin. Cancer Res., September 1, 2001; 7(9): 2636 - 2642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kimura, M. Markowski, C. Bowen, and E. P. Gelmann Androgen Blocks Apoptosis of Hormone-dependent Prostate Cancer Cells Cancer Res., July 1, 2001; 61(14): 5611 - 5618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Graff, J. A. Deddens, B. W. Konicek, B. M. Colligan, B. M. Hurst, H. W. Carter, and J. H. Carter Integrin-linked Kinase Expression Increases with Prostate Tumor Grade Clin. Cancer Res., July 1, 2001; 7(7): 1987 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. George, T. F. Shepard, J. Ma, E. Giovannucci, P. W. Kantoff, and M. J. Stampfer PTEN Polymorphism (IVS4) Is Not Associated with Risk of Prostate Cancer Cancer Epidemiol. Biomarkers Prev., April 1, 2001; 10(4): 411 - 412. [Full Text]
|
|
|
|
|
|
Y. Kanamori, J. Kigawa, H. Itamochi, M. Shimada, M. Takahashi, S. Kamazawa, S. Sato, R. Akeshima, and N. Terakawa Correlation between Loss of PTEN Expression and Akt Phosphorylation in Endometrial Carcinoma Clin. Cancer Res., April 1, 2001; 7(4): 892 - 895. [Abstract] [Full Text]
|
|
|
|
|
|
K. L. Nathanson, R. Omaruddin, S. B. Malkowicz, and T. R. Rebbeck An Intronic Variant in PTEN Is Not Associated with Prostate Cancer Risk Cancer Epidemiol. Biomarkers Prev., March 1, 2001; 10(3): 277 - 278. [Full Text]
|
|
|
|
|
|
A. R. Gottschalk, D. Basila, M. Wong, N. M. Dean, C. H. Brandts, D. Stokoe, and D. A. Haas-Kogan p27Kip1 Is Required for PTEN-induced G1 Growth Arrest Cancer Res., March 1, 2001; 61(5): 2105 - 2111. [Abstract] [Full Text]
|
|
|
|
|
|
G. Kulik, J. P. Carson, T. Vomastek, K. Overman, B. D. Gooch, S. Srinivasula, E. Alnemri, G. Nunez, and M. J. Weber Tumor Necrosis Factor {{alpha}} Induces BID Cleavage and Bypasses Antiapoptotic Signals in Prostate Cancer LNCaP Cells Cancer Res., March 1, 2001; 61(6): 2713 - 2719. [Abstract] [Full Text]
|
|
|
|
|
|
J.-T. Dong, C.-L. Li, T. W. Sipe, and H. F. Frierson Jr. Mutations of PTEN/MMAC1 in Primary Prostate Cancers from Chinese Patients Clin. Cancer Res., February 1, 2001; 7(2): 304 - 308. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. Abate-Shen and M. M. Shen Molecular genetics of prostate cancer Genes & Dev., October 1, 2000; 14(19): 2410 - 2434. [Full Text]
|
|
|
|
|
|
G. L. Semenza HIF-1 and human disease: one highly involved factor Genes & Dev., August 15, 2000; 14(16): 1983 - 1991. [Full Text]
|
|
|
|
|
|
V. Stambolic, M.-S. Tsao, D. Macpherson, A. Suzuki, W. B. Chapman, and T. W. Mak High Incidence of Breast and Endometrial Neoplasia Resembling Human Cowden Syndrome in pten+/- Mice Cancer Res., July 1, 2000; 60(13): 3605 - 3611. [Abstract] [Full Text]
|
|
|
|
|
|
I. U. Ali Gatekeeper for Endometrium: the PTEN Tumor Suppressor Gene J Natl Cancer Inst, June 7, 2000; 92(11): 861 - 863. [Full Text] [PDF]
|
|
|
|
|
|
H. Zhong, K. Chiles, D. Feldser, E. Laughner, C. Hanrahan, M.-M. Georgescu, J. W. Simons, and G. L. Semenza Modulation of Hypoxia-inducible Factor 1{{alpha}} Expression by the Epidermal Growth Factor/Phosphatidylinositol 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis and Therapeutics Cancer Res., March 1, 2000; 60(6): 1541 - 1545. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Guanti, N. Resta, C. Simone, F. Cariola, I. Demma, P. Fiorente, and M. Gentile Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis Hum. Mol. Genet., January 22, 2000; 9(2): 283 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Gustin, T. Maehama, J. E. Dixon, and D. B. Donner The PTEN Tumor Suppressor Protein Inhibits Tumor Necrosis Factor-induced Nuclear Factor kappa B Activity J. Biol. Chem., July 13, 2001; 276(29): 27740 - 27744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Srivastava, L. Bubendorf, V. Srikantan, L. Fossom, L. Nolan, M. Glasman, X. Leighton, W. Fehrle, S. Pittaluga, M. Raffeld, et al. ANX7, a candidate tumor suppressor gene for prostate cancer PNAS, April 10, 2001; 98(8): 4575 - 4580. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
