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[Cancer Research 59, 4784-4787, October 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 4784-4787, October 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

p53-Mutant Clones and Field Effects in Barrett’s Esophagus1

Laura J. Prevo, Carissa A. Sanchez, Patricia C. Galipeau and Brian J. Reid2

Programs in Cancer Biology and Gastrointestinal Oncology, Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 [L. J. P., C. A. S., P. C. G., B. J. R.], and Departments of Genetics and Medicine, Gastroenterology Division, University of Washington Medical Center, Seattle, Washington 98195 [B. J. R.]

Previous studies have demonstrated multifocal neoplasia in Barrett’s esophagus. We evaluated 213 mapped, flow-purified, endoscopic biopsies to determine the distribution of p53-mutant clones in the Barrett’s segments of 58 patients who had high-grade dysplasia without cancer. Twenty-nine patients (50%) had p53 mutations in their Barrett’s segments, including 3 patients with multiple distinct p53 mutations. p53-mutant clones, including diploid cell populations, underwent expansion from 1 to 9 cm in the Barrett’s segment. In 12 of 29 patients (41%) with a p53 mutation, the same mutation was found at every evaluated level of the metaplastic epithelium. This extensive p53-mutant clonal expansion suggests a somatic genetic basis for previous observations of field effects in Barrett’s esophagus.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.