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[Cancer Research 59, 4804-4807, October 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 4804-4807, October 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Extracellular Signal-regulated Kinase Activation Is Required for Up-Regulation of Vascular Endothelial Growth Factor by Serum Starvation in Human Colon Carcinoma Cells1

Young D. Jung, Kayo Nakano, Wenbiao Liu, Gary E. Gallick and Lee M. Ellis2

Departments of Cancer Biology [Y. D. J., K. N., W. L., G. E. G., L. M. E.] and Surgical Oncology [L. M. E.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor important for colon cancer neovascularization. In previous studies, serum starvation led to induction of VEGF in human colon carcinoma cells. We investigated the possible participation of mitogen-activated protein kinases in serum starvation induction of VEGF in the HT29 human colon carcinoma cell line. The extracellular signal-regulated kinases (Erks) 1 and 2 were activated after 3–6 h of serum starvation. Using transient transfection of VEGF promoter-reporter constructs, serum starvation led to an increase in VEGF promoter activity. An inhibitor of phosphorylation of Erk-1/2 blocked the increase of VEGF expression and promoter activity induced by serum starvation. Serum starvation activates several mitogen-activated protein kinases, but activation of Erk-1/2 is critical for the up-regulation of VEGF mRNA in colon carcinoma cells.




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Copyright © 1999 by the American Association for Cancer Research.