Carcinoma-associated Fibroblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium

Tumor Biology

Carcinoma-associated Fibroblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium¹

Aria F. Olumi², Gary D. Grossfeld², Simon W. Hayward, Peter R. Carroll, Thea D. Tlsty³ and Gerald R. Cunha

Cancer Research Center [A. F. O., T. D. T.] and Departments of Urology [G. D. G., S. W. H., P. R. C., G. R. C.], Pathology [T. D. T.], and Anatomy [G. R. C.], University of California at San Francisco, San Francisco, California 94143

The present study demonstrates that fibroblasts associated withcarcinomas stimulate tumor progression of initiated nontumorigenicepithelial cells both in an in vivo tissue recombination systemand in an in vitro coculture system. Human prostatic carcinoma-associatedfibroblasts grown with initiated human prostatic epithelialcells dramatically stimulated growth and altered histology ofthe epithelial population. This effect was not detected whennormal prostatic fibroblasts were grown with the initiated epithelialcells under the same experimental conditions. In contrast, carcinoma-associatedfibroblasts did not affect growth of normal human prostaticepithelial cells under identical conditions. From these data,we conclude that in this human prostate cancer model, carcinoma-associatedfibroblasts stimulate progression of tumorigenesis. Thus, carcinoma-associatedfibroblasts can direct tumor progression of an initiated prostateepithelial cell.

This article has been cited by other articles:

Y. Lu, W. Yang, C. Qin, L. Zhang, J. Deng, S. Liu, and Z. Qin
Responsiveness of Stromal Fibroblasts to IFN-{gamma} Blocks Tumor Growth via Angiostasis
J. Immunol., November 15, 2009; 183(10): 6413 - 6421.
[Abstract] [Full Text] [PDF]

D. Vindrieux, P. Escobar, and G. Lazennec
Emerging roles of chemokines in prostate cancer
Endocr. Relat. Cancer, September 1, 2009; 16(3): 663 - 673.
[Abstract] [Full Text] [PDF]

H. Rubin
Saturation Density of Skin Fibroblasts as a Quantitative Screen for Human Cancer Susceptibility
Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2366 - 2372.
[Abstract] [Full Text] [PDF]

I. Campbell, K. Polyak, I. Haviv, C. Eng, G. Leone, M. S. Orloff, and M. C. Ostrowski
Clonal Mutations in the Cancer-Associated Fibroblasts: The Case against Genetic Coevolution
Cancer Res., September 1, 2009; 69(17): 6765 - 6769.
[Full Text] [PDF]

N. Paland, I. Kamer, I. Kogan-Sakin, S. Madar, N. Goldfinger, and V. Rotter
Differential Influence of Normal and Cancer-Associated Fibroblasts on the Growth of Human Epithelial Cells in an In vitro Cocultivation Model of Prostate Cancer
Mol. Cancer Res., August 1, 2009; 7(8): 1212 - 1223.
[Abstract] [Full Text] [PDF]

C. M. Ghajar, R. Meier, and M. J. Bissell
Quis Custodiet Ipsos Custodies: Who Watches the Watchmen?
Am. J. Pathol., June 1, 2009; 174(6): 1996 - 1999.
[Abstract] [Full Text] [PDF]

A. K. Witkiewicz, A. Dasgupta, F. Sotgia, I. Mercier, R. G. Pestell, M. Sabel, C. G. Kleer, J. R. Brody, and M. P. Lisanti
An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers
Am. J. Pathol., June 1, 2009; 174(6): 2023 - 2034.
[Abstract] [Full Text] [PDF]

L. Persano, L. Moserle, G. Esposito, V. Bronte, V. Barbieri, M. Iafrate, M. P. Gardiman, P. Larghero, U. Pfeffer, E. Naschberger, et al.
Interferon-{alpha} counteracts the angiogenic switch and reduces tumor cell proliferation in a spontaneous model of prostatic cancer
Carcinogenesis, May 1, 2009; 30(5): 851 - 860.
[Abstract] [Full Text] [PDF]

J. S. Pufnock and J. L. Rothstein
Oncoprotein Signaling Mediates Tumor-Specific Inflammation and Enhances Tumor Progression
J. Immunol., May 1, 2009; 182(9): 5498 - 5506.
[Abstract] [Full Text] [PDF]

F. L. Muehlberg, Y.-H. Song, A. Krohn, S. P. Pinilla, L. H. Droll, X. Leng, M. Seidensticker, J. Ricke, A. M. Altman, E. Devarajan, et al.
Tissue-resident stem cells promote breast cancer growth and metastasis
Carcinogenesis, April 1, 2009; 30(4): 589 - 597.
[Abstract] [Full Text] [PDF]

D. Etemadmoghadam, A. deFazio, R. Beroukhim, C. Mermel, J. George, G. Getz, R. Tothill, A. Okamoto, M. B. Raeder, AOCS Study Group, et al.
Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas
Clin. Cancer Res., February 15, 2009; 15(4): 1417 - 1427.
[Abstract] [Full Text] [PDF]

E. Pazolli, X. Luo, S. Brehm, K. Carbery, J.-J. Chung, J. L. Prior, J. Doherty, S. Demehri, L. Salavaggione, D. Piwnica-Worms, et al.
Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
Cancer Res., February 1, 2009; 69(3): 1230 - 1239.
[Abstract] [Full Text] [PDF]

S. Madar, R. Brosh, Y. Buganim, O. Ezra, I. Goldstein, H. Solomon, I. Kogan, N. Goldfinger, H. Klocker, and V. Rotter
Modulated expression of WFDC1 during carcinogenesis and cellular senescence
Carcinogenesis, January 1, 2009; 30(1): 20 - 27.
[Abstract] [Full Text] [PDF]

E. Katz, K. Skorecki, and M. Tzukerman
Niche-Dependent Tumorigenic Capacity of Malignant Ovarian Ascites-Derived Cancer Cell Subpopulations
Clin. Cancer Res., January 1, 2009; 15(1): 70 - 80.
[Abstract] [Full Text] [PDF]

Y. C. Kim, R. J. Clark, E. A. Ranheim, and C. M. Alexander
Wnt1 Expression Induces Short-Range and Long-Range Cell Recruitments That Modify Mammary Tumor Development and Are Not Induced by a Cell-Autonomous {beta}-Catenin Effector
Cancer Res., December 15, 2008; 68(24): 10145 - 10153.
[Abstract] [Full Text] [PDF]

N. Rocks, G. Paulissen, F. Quesada-Calvo, C. Munaut, M.-L. A. Gonzalez, M. Gueders, J. Hacha, C. Gilles, J.-M. Foidart, A. Noel, et al.
ADAMTS-1 Metalloproteinase Promotes Tumor Development through the Induction of a Stromal Reaction In vivo
Cancer Res., November 15, 2008; 68(22): 9541 - 9550.
[Abstract] [Full Text] [PDF]

G. Trimis, I. Chatzistamou, K. Politi, H. Kiaris, and A. G. Papavassiliou
Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors
Hum. Mol. Genet., November 15, 2008; 17(22): 3596 - 3600.
[Abstract] [Full Text] [PDF]

A. Vonlaufen, P. A. Phillips, Z. Xu, D. Goldstein, R. C. Pirola, J. S. Wilson, and M. V. Apte
Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance
Cancer Res., October 1, 2008; 68(19): 7707 - 7710.
[Abstract] [Full Text] [PDF]

B. D. Lehmann, M. S. Paine, A. M. Brooks, J. A. McCubrey, R. H. Renegar, R. Wang, and D. M. Terrian
Senescence-Associated Exosome Release from Human Prostate Cancer Cells
Cancer Res., October 1, 2008; 68(19): 7864 - 7871.
[Abstract] [Full Text] [PDF]

G. P. Risbridger and R. A. Taylor
Regulation of Prostatic Stem Cells by Stromal Niche in Health and Disease
Endocrinology, September 1, 2008; 149(9): 4303 - 4306.
[Abstract] [Full Text] [PDF]

X. Guo, H. Oshima, T. Kitmura, M. M. Taketo, and M. Oshima
Stromal Fibroblasts Activated by Tumor Cells Promote Angiogenesis in Mouse Gastric Cancer
J. Biol. Chem., July 11, 2008; 283(28): 19864 - 19871.
[Abstract] [Full Text] [PDF]

J.-P. Coppe, M. Boysen, C. H. Sun, B. J.F. Wong, M. K. Kang, N.-H. Park, P.-Y. Desprez, J. Campisi, and A. Krtolica
A Role for Fibroblasts in Mediating the Effects of Tobacco-Induced Epithelial Cell Growth and Invasion
Mol. Cancer Res., July 1, 2008; 6(7): 1085 - 1098.
[Abstract] [Full Text] [PDF]

T. Goodpaster, A. Legesse-Miller, M. R. Hameed, S. C. Aisner, J. Randolph-Habecker, and H. A. Coller
An Immunohistochemical Method for Identifying Fibroblasts in Formalin-fixed, Paraffin-embedded Tissue
J. Histochem. Cytochem., April 1, 2008; 56(4): 347 - 358.
[Abstract] [Full Text] [PDF]

A. Vonlaufen, S. Joshi, C. Qu, P. A. Phillips, Z. Xu, N. R. Parker, C. S. Toi, R. C. Pirola, J. S. Wilson, D. Goldstein, et al.
Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells
Cancer Res., April 1, 2008; 68(7): 2085 - 2093.
[Abstract] [Full Text] [PDF]

X. Liu, J. D. Allen, J. T. Arnold, and M. R. Blackman
Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells
Carcinogenesis, April 1, 2008; 29(4): 816 - 823.
[Abstract] [Full Text] [PDF]

J. Wels, R. N. Kaplan, S. Rafii, and D. Lyden
Migratory neighbors and distant invaders: tumor-associated niche cells
Genes & Dev., March 1, 2008; 22(5): 559 - 574.
[Abstract] [Full Text] [PDF]

J. Y. Cha, Q. T. Lambert, G. W. Reuther, and C. J. Der
Involvement of Fibroblast Growth Factor Receptor 2 Isoform Switching in Mammary Oncogenesis
Mol. Cancer Res., March 1, 2008; 6(3): 435 - 445.
[Abstract] [Full Text] [PDF]

R. F. Hwang, T. Moore, T. Arumugam, V. Ramachandran, K. D. Amos, A. Rivera, B. Ji, D. B. Evans, and C. D. Logsdon
Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression
Cancer Res., February 1, 2008; 68(3): 918 - 926.
[Abstract] [Full Text] [PDF]

S. Yang, L. K. Pham, C.-P. Liao, B. Frenkel, A. H. Reddi, and P. Roy-Burman
A Novel Bone Morphogenetic Protein Signaling in Heterotypic Cell Interactions in Prostate Cancer
Cancer Res., January 1, 2008; 68(1): 198 - 205.
[Abstract] [Full Text] [PDF]

H. Koyama, N. Kobayashi, M. Harada, M. Takeoka, Y. Kawai, K. Sano, M. Fujimori, J. Amano, T. Ohhashi, R. Kannagi, et al.
Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis: Pivotal Role of a Hyaluronan-Rich Tumor Microenvironment
Am. J. Pathol., January 1, 2008; 172(1): 179 - 193.
[Abstract] [Full Text] [PDF]

E. Gounaris, S. E. Erdman, C. Restaino, M. F. Gurish, D. S. Friend, F. Gounari, D. M. Lee, G. Zhang, J. N. Glickman, K. Shin, et al.
Mast cells are an essential hematopoietic component for polyp development
PNAS, December 11, 2007; 104(50): 19977 - 19982.
[Abstract] [Full Text] [PDF]

T. Kitamura and M. M. Taketo
Keeping Out the Bad Guys: Gateway to Cellular Target Therapy
Cancer Res., November 1, 2007; 67(21): 10099 - 10102.
[Abstract] [Full Text] [PDF]

X. Zhang, L. Zhang, H. Yang, X. Huang, H. Otu, T. A. Libermann, W. C. DeWolf, R. Khosravi-Far, and A. F. Olumi
c-Fos as a Proapoptotic Agent in TRAIL-Induced Apoptosis in Prostate Cancer Cells
Cancer Res., October 1, 2007; 67(19): 9425 - 9434.
[Abstract] [Full Text] [PDF]

W. Li, C.-L. Wu, P. G. Febbo, and A. F. Olumi
Stromally Expressed c-Jun Regulates Proliferation of Prostate Epithelial Cells
Am. J. Pathol., October 1, 2007; 171(4): 1189 - 1198.
[Abstract] [Full Text] [PDF]

Y. He, O. E. Franco, M. Jiang, K. Williams, H. D. Love, I. M. Coleman, P. S. Nelson, and S. W. Hayward
Tissue-Specific Consequences of Cyclin D1 Overexpression in Prostate Cancer Progression
Cancer Res., September 1, 2007; 67(17): 8188 - 8197.
[Abstract] [Full Text] [PDF]

S. Nakao, Y. Hata, M. Miura, K. Noda, Y. N. Kimura, S. Kawahara, T. Kita, T. Hisatomi, T. Nakazawa, Y. Jin, et al.
Dexamethasone Inhibits Interleukin-1{beta}-Induced Corneal Neovascularization: Role of Nuclear Factor-{kappa}B-Activated Stromal Cells in Inflammatory Angiogenesis
Am. J. Pathol., September 1, 2007; 171(3): 1058 - 1065.
[Abstract] [Full Text] [PDF]

C.-Q. Zhu, S. N. Popova, E. R. S. Brown, D. Barsyte-Lovejoy, R. Navab, W. Shih, M. Li, M. Lu, I. Jurisica, L. Z. Penn, et al.
Integrin {alpha}11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells
PNAS, July 10, 2007; 104(28): 11754 - 11759.
[Abstract] [Full Text] [PDF]

X.-H. Liu, A. Kirschenbaum, S. Yao, G. Liu, S. A. Aaronson, and A. C. Levine
Androgen-Induced Wnt Signaling in Preosteoblasts Promotes the Growth of MDA-PCa-2b Human Prostate Cancer Cells
Cancer Res., June 15, 2007; 67(12): 5747 - 5753.
[Abstract] [Full Text] [PDF]

J. C. O'Connor, M. C. Farach-Carson, C. J. Schneider, and D. D. Carson
Coculture with Prostate Cancer Cells Alters Endoglin Expression and Attenuates Transforming Growth Factor-{beta} Signaling in Reactive Bone Marrow Stromal Cells
Mol. Cancer Res., June 1, 2007; 5(6): 585 - 603.
[Abstract] [Full Text] [PDF]

M. Ao, O. E. Franco, D. Park, D. Raman, K. Williams, and S. W. Hayward
Cross-talk between Paracrine-Acting Cytokine and Chemokine Pathways Promotes Malignancy in Benign Human Prostatic Epithelium
Cancer Res., May 1, 2007; 67(9): 4244 - 4253.
[Abstract] [Full Text] [PDF]

M. R. Nazareth, L. Broderick, M. R. Simpson-Abelson, R. J. Kelleher Jr., S. J. Yokota, and R. B. Bankert
Characterization of Human Lung Tumor-Associated Fibroblasts and Their Ability to Modulate the Activation of Tumor-Associated T Cells
J. Immunol., May 1, 2007; 178(9): 5552 - 5562.
[Abstract] [Full Text] [PDF]

D. Liu and P. J. Hornsby
Senescent Human Fibroblasts Increase the Early Growth of Xenograft Tumors via Matrix Metalloproteinase Secretion
Cancer Res., April 1, 2007; 67(7): 3117 - 3126.
[Abstract] [Full Text] [PDF]

T. Tsujino, I. Seshimo, H. Yamamoto, C. Y. Ngan, K. Ezumi, I. Takemasa, M. Ikeda, M. Sekimoto, N. Matsuura, and M. Monden
Stromal Myofibroblasts Predict Disease Recurrence for Colorectal Cancer
Clin. Cancer Res., April 1, 2007; 13(7): 2082 - 2090.
[Abstract] [Full Text] [PDF]

D. Mahadevan and D. D. Von Hoff
Tumor-stroma interactions in pancreatic ductal adenocarcinoma
Mol. Cancer Ther., April 1, 2007; 6(4): 1186 - 1197.
[Abstract] [Full Text] [PDF]

M. J. Willhauck, N. Mirancea, S. Vosseler, A. Pavesio, P. Boukamp, M. M. Mueller, N. E. Fusenig, and H.-J. Stark
Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation
Carcinogenesis, March 1, 2007; 28(3): 595 - 610.
[Abstract] [Full Text] [PDF]

E. F. Redente, D. J. Orlicky, R. J. Bouchard, and A. M. Malkinson
Tumor Signaling to the Bone Marrow Changes the Phenotype of Monocytes and Pulmonary Macrophages during Urethane-Induced Primary Lung Tumorigenesis in A/J Mice
Am. J. Pathol., February 1, 2007; 170(2): 693 - 708.
[Abstract] [Full Text] [PDF]

P. Cano, A. Godoy, R. Escamilla, R. Dhir, and S. A. Onate
Stromal-Epithelial Cell Interactions and Androgen Receptor-Coregulator Recruitment Is Altered in the Tissue Microenvironment of Prostate Cancer
Cancer Res., January 15, 2007; 67(2): 511 - 519.
[Abstract] [Full Text] [PDF]

S. Bruno, B. Bussolati, C. Grange, F. Collino, M. E. Graziano, U. Ferrando, and G. Camussi
CD133+ Renal Progenitor Cells Contribute to Tumor Angiogenesis
Am. J. Pathol., December 1, 2006; 169(6): 2223 - 2235.
[Abstract] [Full Text] [PDF]

W. Lederle, H.-J. Stark, M. Skobe, N. E. Fusenig, and M. M. Mueller
Platelet-Derived Growth Factor-BB Controls Epithelial Tumor Phenotype by Differential Growth Factor Regulation in Stromal Cells
Am. J. Pathol., November 1, 2006; 169(5): 1767 - 1783.
[Abstract] [Full Text] [PDF]

G. Yang, D. G. Rosen, Z. Zhang, R. C. Bast Jr., G. B. Mills, J. A. Colacino, I. Mercado-Uribe, and J. Liu
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
PNAS, October 31, 2006; 103(44): 16472 - 16477.
[Abstract] [Full Text] [PDF]

J.-P. Coppe, K. Kauser, J. Campisi, and C. M. Beausejour
Secretion of Vascular Endothelial Growth Factor by Primary Human Fibroblasts at Senescence
J. Biol. Chem., October 6, 2006; 281(40): 29568 - 29574.
[Abstract] [Full Text] [PDF]

J. B. Sneddon, H. H. Zhen, K. Montgomery, M. van de Rijn, A. D. Tward, R. West, H. Gladstone, H. Y. Chang, G. S. Morganroth, A. E. Oro, et al.
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
PNAS, October 3, 2006; 103(40): 14842 - 14847.
[Abstract] [Full Text] [PDF]

M. Singh and L. Johnson
Using genetically engineered mouse models of cancer to aid drug development: an industry perspective.
Clin. Cancer Res., September 15, 2006; 12(18): 5312 - 5328.
[Abstract] [Full Text] [PDF]

M. Ao, K. Williams, N. A. Bhowmick, and S. W. Hayward
Transforming Growth Factor-{beta} Promotes Invasion in Tumorigenic but not in Nontumorigenic Human Prostatic Epithelial Cells
Cancer Res., August 15, 2006; 66(16): 8007 - 8016.
[Abstract] [Full Text] [PDF]

D. E. Costea, K. Kulasekara, E. Neppelberg, A. C. Johannessen, and O. K. Vintermyr
Species-Specific Fibroblasts Required for Triggering Invasiveness of Partially Transformed Oral Keratinocytes
Am. J. Pathol., June 1, 2006; 168(6): 1889 - 1897.
[Abstract] [Full Text] [PDF]

A. Y. Khakoo, S. Pati, S. A. Anderson, W. Reid, M. F. Elshal, I. I. Rovira, A. T. Nguyen, D. Malide, C. A. Combs, G. Hall, et al.
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
J. Exp. Med., May 15, 2006; 203(5): 1235 - 1247.
[Abstract] [Full Text] [PDF]

H. Le, J. T. Arnold, K. K. McFann, and M. R. Blackman
DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E952 - E960.
[Abstract] [Full Text] [PDF]

M. Tzukerman, T. Rosenberg, I. Reiter, S. Ben-Eliezer, G. Denkberg, R. Coleman, Y. Reiter, and K. Skorecki
The influence of a human embryonic stem cell-derived microenvironment on targeting of human solid tumor xenografts.
Cancer Res., April 1, 2006; 66(7): 3792 - 3801.
[Abstract] [Full Text] [PDF]

S. Indraccolo, L. Stievano, S. Minuzzo, V. Tosello, G. Esposito, E. Piovan, R. Zamarchi, L. Chieco-Bianchi, and A. Amadori
Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment.
PNAS, March 14, 2006; 103(11): 4216 - 4221.
[Abstract] [Full Text] [PDF]

C. Bavik, I. Coleman, J. P. Dean, B. Knudsen, S. Plymate, and P. S. Nelson
The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms
Cancer Res., January 15, 2006; 66(2): 794 - 802.
[Abstract] [Full Text] [PDF]

P. A. Watson, K. Ellwood-Yen, J. C. King, J. Wongvipat, M. M. LeBeau, and C. L. Sawyers
Context-Dependent Hormone-Refractory Progression Revealed through Characterization of a Novel Murine Prostate Cancer Cell Line
Cancer Res., December 15, 2005; 65(24): 11565 - 11571.
[Abstract] [Full Text] [PDF]

M. S. Joesting, S. Perrin, B. Elenbaas, S. E. Fawell, J. S. Rubin, O. E. Franco, S. W. Hayward, G. R. Cunha, and P. C. Marker
Identification of SFRP1 as a Candidate Mediator of Stromal-to-Epithelial Signaling in Prostate Cancer
Cancer Res., November 15, 2005; 65(22): 10423 - 10430.
[Abstract] [Full Text] [PDF]

D. W. Miller, S. Vosseler, N. Mirancea, D. J. Hicklin, P. Bohlen, H. E. Volcker, F. G. Holz, and N. E. Fusenig
Rapid Vessel Regression, Protease Inhibition, and Stromal Normalization upon Short-Term Vascular Endothelial Growth Factor Receptor 2 Inhibition in Skin Carcinoma Heterotransplants
Am. J. Pathol., November 1, 2005; 167(5): 1389 - 1403.
[Abstract] [Full Text] [PDF]

M. V. Maffini, J. M. Calabro, A. M. Soto, and C. Sonnenschein
Stromal Regulation of Neoplastic Development: Age-Dependent Normalization of Neoplastic Mammary Cells by Mammary Stroma
Am. J. Pathol., November 1, 2005; 167(5): 1405 - 1410.
[Abstract] [Full Text] [PDF]

M. Galie, C. Sorrentino, M. Montani, L. Micossi, E. Di Carlo, T. D'Antuono, L. Calderan, P. Marzola, D. Benati, F. Merigo, et al.
Mammary carcinoma provides highly tumourigenic and invasive reactive stromal cells
Carcinogenesis, November 1, 2005; 26(11): 1868 - 1878.
[Abstract] [Full Text] [PDF]

D. Lithgow and C. Covington
Chronic Inflammation and Breast Pathology: A Theoretical Model
Biol Res Nurs, October 1, 2005; 7(2): 118 - 129.
[Abstract] [PDF]

E Sivridis, A Giatromanolaki, and M I Koukourakis
Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress
J. Clin. Pathol., October 1, 2005; 58(10): 1033 - 1038.
[Abstract] [Full Text] [PDF]

L. Xie, G. Tsaprailis, and Q. M. Chen
Proteomic Identification of Insulin-like Growth Factor-binding Protein-6 Induced by Sublethal H2O2 Stress from Human Diploid Fibroblasts
Mol. Cell. Proteomics, September 1, 2005; 4(9): 1273 - 1283.
[Abstract] [Full Text] [PDF]

M. D. Amatangelo, D. E. Bassi, A. J.P. Klein-Szanto, and E. Cukierman
Stroma-Derived Three-Dimensional Matrices Are Necessary and Sufficient to Promote Desmoplastic Differentiation of Normal Fibroblasts
Am. J. Pathol., August 1, 2005; 167(2): 475 - 488.
[Abstract] [Full Text] [PDF]

J. Kim, P. Yang, M. Suraokar, A. L. Sabichi, N. D. Llansa, G. Mendoza, V. Subbarayan, C. J. Logothetis, R. A. Newman, S. M. Lippman, et al.
Suppression of Prostate Tumor Cell Growth by Stromal Cell Prostaglandin D Synthase-Derived Products
Cancer Res., July 15, 2005; 65(14): 6189 - 6198.
[Abstract] [Full Text] [PDF]

L. Xi, J. Lyons-Weiler, M. C. Coello, X. Huang, W. E. Gooding, J. D. Luketich, and T. E. Godfrey
Prediction of Lymph Node Metastasis by Analysis of Gene Expression Profiles in Primary Lung Adenocarcinomas
Clin. Cancer Res., June 1, 2005; 11(11): 4128 - 4135.
[Abstract] [Full Text] [PDF]

C. H. Stuelten, S. D. Byfield, P. R. Arany, T. S. Karpova, W. G. Stetler-Stevenson, and A. B. Roberts
Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-{alpha} and TGF-{beta}
J. Cell Sci., May 15, 2005; 118(10): 2143 - 2153.
[Abstract] [Full Text] [PDF]

B. Grum-Schwensen, J. Klingelhofer, C. H. Berg, C. El-Naaman, M. Grigorian, E. Lukanidin, and N. Ambartsumian
Suppression of Tumor Development and Metastasis Formation in Mice Lacking the S100A4(mts1) Gene
Cancer Res., May 1, 2005; 65(9): 3772 - 3780.
[Abstract] [Full Text] [PDF]

H. Kiaris, I. Chatzistamou, G. Trimis, M. Frangou-Plemmenou, A. Pafiti-Kondi, and A. Kalofoutis
Evidence for Nonautonomous Effect of p53 Tumor Suppressor in Carcinogenesis
Cancer Res., March 1, 2005; 65(5): 1627 - 1630.
[Abstract] [Full Text] [PDF]

A. Margulis, W. Zhang, A. Alt-Holland, H. C. Crawford, N. E. Fusenig, and J. A. Garlick
E-cadherin Suppression Accelerates Squamous Cell Carcinoma Progression in Three-Dimensional, Human Tissue Constructs
Cancer Res., March 1, 2005; 65(5): 1783 - 1791.
[Abstract] [Full Text] [PDF]

S. Vosseler, N. Mirancea, P. Bohlen, M. M. Mueller, and N. E. Fusenig
Angiogenesis Inhibition by Vascular Endothelial Growth Factor Receptor-2 Blockade Reduces Stromal Matrix Metalloproteinase Expression, Normalizes Stromal Tissue, and Reverts Epithelial Tumor Phenotype in Surface Heterotransplants
Cancer Res., February 15, 2005; 65(4): 1294 - 1305.
[Abstract] [Full Text] [PDF]

V. Laurent-Matha, S. Maruani-Herrmann, C. Prebois, M. Beaujouin, M. Glondu, A. Noel, M. L. Alvarez-Gonzalez, S. Blacher, P. Coopman, S. Baghdiguian, et al.
Catalytically inactive human cathepsin D triggers fibroblast invasive growth
J. Cell Biol., January 31, 2005; 168(3): 489 - 499.
[Abstract] [Full Text] [PDF]

M.J. BISSELL, P.A. KENNY, and D.C. RADISKY
Microenvironmental Regulators of Tissue Structure and Function Also Regulate Tumor Induction and Progression: The Role of Extracellular Matrix and Its Degrading Enzymes
Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 343 - 356.
[Abstract] [PDF]

M. EGEBLAD, L.E. LITTLEPAGE, and Z. WERB
The Fibroblastic Coconspirator in Cancer Progression
Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 383 - 388.
[Abstract] [PDF]

C. Sonnenschein and A. M. Soto
Are Times a' Changin' in Carcinogenesis?
Endocrinology, January 1, 2005; 146(1): 11 - 12.
[Full Text] [PDF]

W. W. Barclay, R. D. Woodruff, M. C. Hall, and S. D. Cramer
A System for Studying Epithelial-Stromal Interactions Reveals Distinct Inductive Abilities of Stromal Cells from Benign Prostatic Hyperplasia and Prostate Cancer
Endocrinology, January 1, 2005; 146(1): 13 - 18.
[Abstract] [Full Text] [PDF]

A. Y. Liu, M. P. Roudier, and L. D. True
Heterogeneity in Primary and Metastatic Prostate Cancer as Defined by Cell Surface CD Profile
Am. J. Pathol., November 1, 2004; 165(5): 1543 - 1556.
[Abstract] [Full Text] [PDF]

A. K. Bauer, A. M. Malkinson, and S. R. Kleeberger
Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities
Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L685 - L703.
[Abstract] [Full Text] [PDF]

M. Hu, K. L. Carles-Kinch, D. P. Zelinski, and M. S. Kinch
EphA2 Induction of Fibronectin Creates a Permissive Microenvironment for Malignant Cells
Mol. Cancer Res., October 1, 2004; 2(10): 533 - 540.
[Abstract] [Full Text] [PDF]

N. Jessani, M. Humphrey, W. H. McDonald, S. Niessen, K. Masuda, B. Gangadharan, J. R. Yates III, B. M. Mueller, and B. F. Cravatt
Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo
PNAS, September 21, 2004; 101(38): 13756 - 13761.
[Abstract] [Full Text] [PDF]

H. Parmar and G. R Cunha
Epithelial-stromal interactions in the mouse and human mammary gland in vivo
Endocr. Relat. Cancer, September 1, 2004; 11(3): 437 - 458.
[Abstract] [Full Text] [PDF]

D. G. Duda, D. Fukumura, L. L. Munn, M. F. Booth, E. B. Brown, P. Huang, B. Seed, and R. K. Jain
Differential Transplantability of Tumor-Associated Stromal Cells
Cancer Res., September 1, 2004; 64(17): 5920 - 5924.
[Abstract] [Full Text] [PDF]

E. L. Rosenthal, A. McCrory, M. Talbert, W. Carroll, J. S. Magnuson, and G. E. Peters
Expression of Proteolytic Enzymes in Head and Neck Cancer-Associated Fibroblasts
Arch Otolaryngol Head Neck Surg, August 1, 2004; 130(8): 943 - 947.
[Abstract] [Full Text] [PDF]

L. Fan, C. V. Pepicelli, C. C. Dibble, W. Catbagan, J. L. Zarycki, R. Laciak, J. Gipp, A. Shaw, M. L. G. Lamm, A. Munoz, et al.
Hedgehog Signaling Promotes Prostate Xenograft Tumor Growth
Endocrinology, August 1, 2004; 145(8): 3961 - 3970.
[Abstract] [Full Text] [PDF]

M. V. Maffini, A. M. Soto, J. M. Calabro, A. A. Ucci, and C. Sonnenschein
The stroma as a crucial target in rat mammary gland carcinogenesis
J. Cell Sci., March 15, 2004; 117(8): 1495 - 1502.
[Abstract] [Full Text] [PDF]

T. Maeda, C. M. Alexander, and A. Friedl
Induction of Syndecan-1 Expression in Stromal Fibroblasts Promotes Proliferation of Human Breast Cancer Cells
Cancer Res., January 15, 2004; 64(2): 612 - 621.
[Abstract] [Full Text] [PDF]

T. Schuler, S. Kornig, and T. Blankenstein
Tumor Rejection by Modulation of Tumor Stromal Fibroblasts
J. Exp. Med., November 17, 2003; 198(10): 1487 - 1493.
[Abstract] [Full Text] [PDF]

M. Tzukerman, T. Rosenberg, Y. Ravel, I. Reiter, R. Coleman, and K. Skorecki
An experimental platform for studying growth and invasiveness of tumor cells within teratomas derived from human embryonic stem cells
PNAS, November 11, 2003; 100(23): 13507 - 13512.
[Abstract] [Full Text] [PDF]

X. Wu, C. Jin, F. Wang, C. Yu, and W. L. McKeehan
Stromal Cell Heterogeneity in Fibroblast Growth Factor-mediated Stromal-Epithelial Cell Cross-Talk in Premalignant Prostate Tumors
Cancer Res., August 15, 2003; 63(16): 4936 - 4944.
[Abstract] [Full Text] [PDF]

K. L. Schmeichel and M. J. Bissell
Modeling tissue-specific signaling and organ function in three dimensions
J. Cell Sci., June 15, 2003; 116(12): 2377 - 2388.
[Abstract] [Full Text] [PDF]

G. Castoria, M. Lombardi, M. V. Barone, A. Bilancio, M. Di Domenico, D. Bottero, F. Vitale, A. Migliaccio, and F. Auricchio
Androgen-stimulated DNA synthesis and cytoskeletal changes in fibroblasts by a nontranscriptional receptor action
J. Cell Biol., May 12, 2003; 161(3): 547 - 556.
[Abstract] [Full Text] [PDF]

B.-e. Wang, J. Shou, S. Ross, H. Koeppen, F. J. de Sauvage, and W.-Q. Gao
Inhibition of Epithelial Ductal Branching in the Prostate by Sonic Hedgehog Is Indirectly Mediated by Stromal Cells
J. Biol. Chem., May 9, 2003; 278(20): 18506 - 18513.
[Abstract] [Full Text] [PDF]

N. S. Cutler, R. Graves-Deal, B. J. LaFleur, Z. Gao, B. M. Boman, R. H. Whitehead, E. Terry, J. D. Morrow, and R. J. Coffey
Stromal Production of Prostacyclin Confers an Antiapoptotic Effect to Colonic Epithelial Cells
Cancer Res., April 15, 2003; 63(8): 1748 - 1751.
[Abstract] [Full Text] [PDF]