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Departments of Microbiology and Cancer Center [D. G., M. J. W.], Pathology [J. W. M., H. F. F.], and Health Evaluation Services [G. R. P.], University of Virginia Health Sciences Center, Charlottesville, Virginia 22908
Using an antibody specific for dually phosphorylated extracellular-regulated kinases 1 and 2, we have examined 82 primary and metastatic prostate tumor specimens for the presence of activated mitogen-activated protein (MAP) kinase. Nonneoplastic prostate tissue showed little or no staining with activated MAP kinase antiserum. In prostate tumors, the level of activated MAP kinase increased with increasing Gleason score and tumor stage. In a separate analysis, tumor samples from two patients showed no activation of MAP kinase before androgen ablation therapy; however, following androgen ablation treatment, high levels of activated MAP kinase were detected in the recurrent tumors. Collectively, these data suggest an increase in the activation of the MAP kinase signal transduction pathway as prostate cancer progresses to a more advanced and androgen-independent disease.
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R. P. Singh, G. Sharma, G. U. Mallikarjuna, S. Dhanalakshmi, C. Agarwal, and R. Agarwal In Vivo Suppression of Hormone-Refractory Prostate Cancer Growth by Inositol Hexaphosphate: Induction of Insulin-Like Growth Factor Binding Protein-3 and Inhibition of Vascular Endothelial Growth Factor Clin. Cancer Res., January 1, 2004; 10(1): 244 - 250. [Abstract] [Full Text] [PDF]
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J. W. Mandell Phosphorylation State-Specific Antibodies: Applications in Investigative and Diagnostic Pathology Am. J. Pathol., November 1, 2003; 163(5): 1687 - 1698. [Abstract] [Full Text] [PDF]
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K. Jorgensen, R. Holm, G. M. Maelandsmo, and V. A. Florenes Expression of Activated Extracellular Signal-Regulated Kinases 1/2 in Malignant Melanomas: Relationship with Clinical Outcome Clin. Cancer Res., November 1, 2003; 9(14): 5325 - 5331. [Abstract] [Full Text] [PDF]
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Y. Tanaka, M. V. Gavrielides, Y. Mitsuuchi, T. Fujii, and M. G. Kazanietz Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway J. Biol. Chem., September 5, 2003; 278(36): 33753 - 33762. [Abstract] [Full Text] [PDF]
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L. Zhang, M. Johnson, K. H. Le, M. Sato, R. Ilagan, M. Iyer, S. S. Gambhir, L. Wu, and M. Carey Interrogating Androgen Receptor Function in Recurrent Prostate Cancer Cancer Res., August 1, 2003; 63(15): 4552 - 4560. [Abstract] [Full Text] [PDF]
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B. Govindarajan, M. C. Mizesko, M. S. Miller, H. Onda, M. Nunnelly, K. Casper, D. Brat, C. Cohen, and J. L Arbiser Tuberous Sclerosis-associated Neoplasms Express Activated p42/44 Mitogen-activated Protein (MAP) Kinase, and Inhibition of MAP Kinase Signaling Results in Decreased in Vivo Tumor Growth Clin. Cancer Res., August 1, 2003; 9(9): 3469 - 3475. [Abstract] [Full Text] [PDF]
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Y. Hu, M. Bally, W. H. Dragowska, and L. Mayer Inhibition of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase Enhances Chemotherapeutic Effects on H460 Human Non-Small Cell Lung Cancer Cells through Activation of Apoptosis Mol. Cancer Ther., July 1, 2003; 2(7): 641 - 649. [Abstract] [Full Text] [PDF]
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V. Sung, W. Luo, D. Qian, I. Lee, B. Jallal, and M. Gishizky The Ste20 Kinase MST4 Plays a Role in Prostate Cancer Progression Cancer Res., June 15, 2003; 63(12): 3356 - 3363. [Abstract] [Full Text] [PDF]
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Y.-W. Lin, S.-M. Chuang, and J.-L. Yang ERK1/2 Achieves Sustained Activation by Stimulating MAPK Phosphatase-1 Degradation via the Ubiquitin-Proteasome Pathway J. Biol. Chem., June 6, 2003; 278(24): 21534 - 21541. [Abstract] [Full Text] [PDF]
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J. S. Taub, R. Guo, L. M. F. Leeb-Lundberg, J. F. Madden, and Y. Daaka Bradykinin Receptor Subtype 1 Expression and Function in Prostate Cancer Cancer Res., May 1, 2003; 63(9): 2037 - 2041. [Abstract] [Full Text] [PDF]
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R. E. Bakin, D. Gioeli, R. A. Sikes, E. A. Bissonette, and M. J. Weber Constitutive Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway Promotes Androgen Hypersensitivity in LNCaP Prostate Cancer Cells Cancer Res., April 15, 2003; 63(8): 1981 - 1989. [Abstract] [Full Text] [PDF]
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R. P. Singh, C. Agarwal, and R. Agarwal Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes Carcinogenesis, March 1, 2003; 24(3): 555 - 563. [Abstract] [Full Text] [PDF]
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 G. M. Carbone, E. M. McGuffie, A. Collier, and C. V. Catapano Selective inhibition of transcription of the Ets2 gene in prostate cancer cells by a triplex-forming oligonucleotide Nucleic Acids Res., February 1, 2003; 31(3): 833 - 843. [Abstract] [Full Text] [PDF]
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 K. D. Burroughs, J. Oh, J. C. Barrett, and R. P. DiAugustine Phosphatidylinositol 3-Kinase and Mek1/2 Are Necessary for Insulin-Like Growth Factor-I-Induced Vascular Endothelial Growth Factor Synthesis in Prostate Epithelial Cells: A Role for Hypoxia-Inducible Factor-1? Mol. Cancer Res., February 1, 2003; 1(4): 312 - 322. [Abstract] [Full Text] [PDF]
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 R. M. Adam, J. Kim, J. Lin, A. Orsola, L. Zhuang, D. C. Rice, and M. R. Freeman* Heparin-Binding Epidermal Growth Factor-Like Growth Factor Stimulates Androgen-Independent Prostate Tumor Growth and Antagonizes Androgen Receptor Function Endocrinology, December 1, 2002; 143(12): 4599 - 4608. [Abstract] [Full Text] [PDF]
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