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[Cancer Research 59, 298-300, January 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 298-300, January 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Asbestos and DNA Double Strand Breaks1

Ryuichi Okayasu2, Sentaro Takahashi, Shigeru Yamada, Tom K. Hei and Robert L. Ullrich

Department of Radiation Oncology–Biology Division, University of Texas Medical Branch, Galveston, Texas 77555-0656 [R. O., R. L. U.]; National Institute of Radiological Sciences, Chiba 263, Japan [S. T., S. Y.]; and Center for Radiological Research, Columbia University, New York, New York 10032 [T. K. H.]

A radiosensitive DNA repair-deficient xrs-5 cell line was used to study asbestos cytotoxicity and DNA double strand breaks (DSBs). Although xrs-5 cells did not show any increase in sensitivity to chrysotile fibers in short-term (4-h) treatment when compared with wild-type CHO cells, longer-term exposure (24 h) gave significantly lower cell survival accompanied by a cell growth delay as well as a higher DNA DSB induction in this mutant cell line. These results suggest an important role played by DNA DSBs at the initial stage of asbestos injury.




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Copyright © 1999 by the American Association for Cancer Research.