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[Cancer Research 59, 307-310, January 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 307-310, January 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Somatic Mutations in the Kinase Domain of the Met/Hepatocyte Growth Factor Receptor Gene in Childhood Hepatocellular Carcinomas1

Won Sang Park, Seung Myung Dong, Su Young Kim, Eun Young Na, Min Sun Shin, Jae Ho Pi, Bum Jun Kim, Jeong Hoon Bae, Young Ki Hong, Kyo Sun Lee, Sug Hyung Lee, Nam Jin Yoo, Ja June Jang, Svetlana Pack, Zhengping Zhuang, Laura Schmidt, Berton Zbar and Jung Young Lee2

Department of Pathology and Cancer Research Institute, Catholic University Medical College, Seoul 137-701, Korea [W. S. P., S. M. D., S. Y. K., E. Y. N., M. S. S., J. H. P., B. J. K., J. H. B., Y. K. H., K. S. L., S. H. L., N. J. Y., J. Y. L.]; Department of Pathology, Seoul National University College of Medicine, Seoul 110-799, Korea [J. J. J.]; Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 [S. P., Z. Z.]; Intramural Research Support Program, Science Applications International Corporation-Frederick [L. S.]; and Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 [B. Z.]

The MET protooncogene encodes a transmembrane tyrosine kinase identified as the receptor of a polypeptide known as hepatocyte growth factor/scatter factor. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the tyrosine kinase domain of the MET gene (exon 15–19) in 75 primary liver cancers. Three missense mutations were detected exclusively in 10 childhood hepatocellular carcinomas (HCCs), while no mutations were detected in 16 adult HCCs, 21 cholangiocarcinomas, or 28 hepatoblastomas. The extremely short incubation period from hepatitis B virus infection to the genesis of childhood HCC as compared with the adult HCC suggests that there may be an additional mechanism that accelerates the carcinogenesis of childhood HCC. Our results indicate that mutations of the tyrosine kinase domain of the MET gene may be involved in the acceleration of the carcinogenesis in childhood HCC.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.