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Deletion of Chromosome 1 Predicts Prognosis in Pancreatic Endocrine Tumors¹

Department of Surgery West Los Angeles Department of Veterans Affairs Medical Center and the University of California at Los Angeles School of Medicine, Los Angeles, California 90073 [S. A. E., E. H. W., A. W., E. P., M. P. S.] and Department of Pediatrics, Cedars-Sinai Medical Center and the University of California at Los Angeles School of Medicine, Los Angeles, California 90048 [R. R. S.]

Endocrine tumors, such as parathyroid adenomas and pheochromocytomas, frequently have deletions of chromosome 1, suggesting that inactivation of a tumor suppressor gene from chromosome 1 is important in their tumorigenesis. We hypothesized that deletion of chromosome 1 may contribute to pancreatic endocrine tumor formation. Twenty-nine sporadic and MEN1 pancreatic endocrine tumors were studied for loss of heterozygosity (LOH) with 12 chromosome 1 microsatellite markers. LOH on chromosome 1 was identified in 10 of 29 (34%) tumors studied. Allele loss occurred more frequently in tumors with hepatic metastases (7 of 8) than tumors without metastases (3 of 21) (P = 0.004). Tumors in patients with lymph node involvement and patients with multiple endocrine neoplasia type 1 did not demonstrate LOH for chromosome 1 markers. These data suggest that loss of chromosome 1 is associated specifically with the development of hepatic metastases in patients with sporadic pancreatic endocrine tumors.

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