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[Cancer Research 59, 320-324, January 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 320-324, January 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Mutational Inactivation of Transforming Growth Factor ß Receptor Type II in Microsatellite Stable Colon Cancers1

William M. Grady2, Lois L. Myeroff2, Sandra E. Swinler, Ashwani Rajput, Sam Thiagalingam, James D. Lutterbaugh, Aaron Neumann, Michael G. Brattain, Jay Chang, Seong-Jin Kim, Ken W. Kinzler, Bert Vogelstein, James K. V. Willson and Sanford Markowitz3

Department of Medicine [W. M. G., J. K. V. W., S. M.], Ireland Cancer Center [W. M. G., L. L. M., S. E. S., J. D. L., J. K. V. W., S. M.], Department of Surgery [A. R.], and BSTP Program [A. N.], Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106; Department of Surgery, University of Texas Health Sciences Center, San Antonio, Texas 78284 [M. G. B.]; Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892 [J. C., S-J. K.]; Molecular Genetics Laboratory, The Johns Hopkins Oncology Center, Baltimore, Maryland 21231 [S. T., K. W. K., B. V.]; and Howard Hughes Medical Institute [J. D. L., B. V., S. M.]

We previously demonstrated that mutational inactivation of transforming growth factor ß type II receptors (RIIs) is very common among the 13% of human colon cancers with microsatellite instability. These mutations principally cluster in the BAT-RII polyadenine sequence repeat. Among microsatellite stable (MSS) colon cancers, we now find that non-BAT-RII point mutations inactivate RII in another 15% of cases, thus doubling the known number of colon cancers in which RII mutations are pathogenetic. Functional analysis confirms that these mutations inactivate RII signaling. Moreover, another 55% of MSS colon cancers demonstrate a transforming growth factor ß signaling blockade distal to RII. The transforming growth factor ß pathway and RII in particular are major targets for inactivation in MSS colon cancers as well as in colon cancers with microsatellite instability.




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J. Exp. Med., May 20, 2002; 195(10): 1247 - 1255.
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Home page
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[Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Cancer Res., May 1, 2001; 61(9): 3801 - 3805.
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Home page
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Home page
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Home page
 J. Med. Genet.Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text]

Home page
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Home page
 JCOHome page
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J. Clin. Oncol., November 1, 2000; 18(90001): 75s - 80.
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Home page
 JNCI J Natl Cancer InstHome page
M. P. de Caestecker, E. Piek, and A. B. Roberts
Role of Transforming Growth Factor-{beta} Signaling in Cancer
J Natl Cancer Inst, September 6, 2000; 92(17): 1388 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
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Role of Transforming Growth Factor {beta} in Human Disease
N. Engl. J. Med., May 4, 2000; 342(18): 1350 - 1358.
[Full Text] [PDF]

Home page
 J. Med. Genet.Home page
S ROTH, M JOHANSSON, A LOUKOLA, P PELTOMÄKI, H JÄRVINEN, J-P MECKLIN, and L A AALTONEN
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J. Med. Genet., April 1, 2000; 37(4): 298 - 301.
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Home page
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PNAS, January 18, 2000; 97(2): 710 - 715.
[Abstract] [Full Text] [PDF]

Home page
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Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-beta Antiproliferative Responses in Colon Cancer Cells
J. Biol. Chem., November 19, 1999; 274(47): 33637 - 33643.
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Home page
 NEJMHome page
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Home page
 Genes Dev.Home page
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Genes & Dev., April 1, 1999; 13(7): 804 - 816.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
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Oncogenic Ras Represses Transforming Growth Factor-beta /Smad Signaling by Degrading Tumor Suppressor Smad4
J. Biol. Chem., July 27, 2001; 276(31): 29531 - 29537.
[Abstract] [Full Text] [PDF]


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