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Department of Urology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas [Y. L., R-C. P., M. C. H., A. I. S., C-P. T., Z. W., J-T. H.], and Division of Immunologic and Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania [J. M. B.]
There is great interest in the development of gene therapeutic strategies for the treatment of benign and malignant diseases. Recombinant adenovirus has a wide spectrum of tissue specificity and is an efficient vector delivery system. Successful gene delivery, however, requires viral entry into the target cells via specific receptor-mediated uptake. Recently, a cDNA clone (the coxsackie and adenovirus receptor [CAR]) encoding a 46-kDa protein was identified as the receptor for group C adenovirus (e.g., adenovirus type 2 and 5). Currently, little is known regarding the expression of adenoviral receptor in normal tissue and cancer. In this paper, we have documented a significant difference in viral receptor levels that may be due to transcriptional regulation of the CAR gene in several human bladder cancer cell lines. The differences in viral receptor levels in these cells correlated with their sensitivity to viral infection. Transfection of receptor-negative cell line with CAR cDNA led to increased virus binding and increased susceptibility to adenovirus-mediated gene delivery. Our results demonstrate that the expression of adenoviral receptor is variable among human bladder cancer cells. This variability may have a significant impact on the outcome of adenovirus-based gene therapy.
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K. A. Rauen, D. Sudilovsky, J. L. Le, K. L. Chew, B. Hann, V. Weinberg, L. D. Schmitt, and F. McCormick Expression of the Coxsackie Adenovirus Receptor in Normal Prostate and in Primary and Metastatic Prostate Carcinoma: Potential Relevance to Gene Therapy Cancer Res., July 1, 2002; 62(13): 3812 - 3818. [Abstract] [Full Text] [PDF]
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A. Hemminki, K. R. Zinn, B. Liu, T. R. Chaudhuri, R. A. Desmond, B. E. Rogers, M. N. Barnes, R. D. Alvarez, and D. T. Curiel In Vivo Molecular Chemotherapy and Noninvasive Imaging With an Infectivity-Enhanced Adenovirus J Natl Cancer Inst, May 15, 2002; 94(10): 741 - 749. [Abstract] [Full Text] [PDF]
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J. I. Izawa, P. Sweeney, P. Perrotte, D. Kedar, Z. Dong, J. W. Slaton, T. Karashima, K. Inoue, W. F. Benedict, and C. P. N. Dinney Inhibition of Tumorigenicity and Metastasis of Human Bladder Cancer Growing in Athymic Mice by Interferon-{beta} Gene Therapy Results Partially from Various Antiangiogenic Effects Including Endothelial Cell Apoptosis Clin. Cancer Res., April 1, 2002; 8(4): 1258 - 1270. [Abstract] [Full Text] [PDF]
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A. Kanerva, G. V. Mikheeva, V. Krasnykh, C. J. Coolidge, J. T. Lam, P. J. Mahasreshti, S. D. Barker, M. Straughn, M. N. Barnes, R. D. Alvarez, et al. Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells Clin. Cancer Res., January 1, 2002; 8(1): 275 - 280. [Abstract] [Full Text] [PDF]
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A. Hemminki, I. Dmitriev, B. Liu, R. A. Desmond, R. Alemany, and D. T. Curiel Targeting Oncolytic Adenoviral Agents to the Epidermal Growth Factor Pathway with a Secretory Fusion Molecule Cancer Res., September 1, 2001; 61(17): 6377 - 6381. [Abstract] [Full Text] [PDF]
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P. K. Tan, A.-I. Michou, J. M. Bergelson, and M. Cotten Defining CAR as a cellular receptor for the avian adenovirus CELO using a genetic analysis of the two viral fibre proteins J. Gen. Virol., June 1, 2001; 82(6): 1465 - 1472. [Abstract] [Full Text]
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T. P. Cripe, E. J. Dunphy, A. D. Holub, A. Saini, N. H. Vasi, Y. Y. Mahller, M. H. Collins, J. D. Snyder, V. Krasnykh, D. T. Curiel, et al. Fiber Knob Modifications Overcome Low, Heterogeneous Expression of the Coxsackievirus-Adenovirus Receptor That Limits Adenovirus Gene Transfer and Oncolysis for Human Rhabdomyosarcoma Cells Cancer Res., April 1, 2001; 61(7): 2953 - 2960. [Abstract] [Full Text]
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J. Grill, V. W. Van Beusechem, P. Van Der Valk, C. M. F. Dirven, A. Leonhart, D. S. Pherai, H. J. Haisma, H. M. Pinedo, D. T. Curiel, and W. R. Gerritsen Combined Targeting of Adenoviruses to Integrins and Epidermal Growth Factor Receptors Increases Gene Transfer into Primary Glioma Cells and Spheroids Clin. Cancer Res., March 1, 2001; 7(3): 641 - 650. [Abstract] [Full Text]
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J. T. Douglas, M. Kim, L. A. Sumerel, D. E. Carey, and D. T. Curiel Efficient Oncolysis by a Replicating Adenovirus (Ad) in Vivo Is Critically Dependent on Tumor Expression of Primary Ad Receptors Cancer Res., February 1, 2001; 61(3): 813 - 817. [Abstract] [Full Text]
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C. Ebbinghaus, A. Al-Jaibaji, E. Operschall, A. Schöffel, I. Peter, U. F. Greber, and S. Hemmi Functional and Selective Targeting of Adenovirus to High-Affinity Fc{gamma} Receptor I-Positive Cells by Using a Bispecific Hybrid Adapter J. Virol., January 1, 2001; 75(1): 480 - 489. [Abstract] [Full Text]
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K. Suzuki, J. Fueyo, V. Krasnykh, P. N. Reynolds, D. T. Curiel, and R. Alemany A Conditionally Replicative Adenovirus with Enhanced Infectivity Shows Improved Oncolytic Potency Clin. Cancer Res., January 1, 2001; 7(1): 120 - 126. [Abstract] [Full Text]
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C.-T. Lee, J. Y. Seol, K.-H. Park, C.-G. Yoo, Y. W. Kim, C. Ahn, Y.-W. Song, S. K. Han, J. S. Han, S. Kim, et al. Differential Effects of Adenovirus-p16 on Bladder Cancer Cell Lines Can Be Overcome by the Addition of Butyrate Clin. Cancer Res., January 1, 2001; 7(1): 210 - 214. [Abstract] [Full Text]
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E. R. Sauter, M. Nesbit, S. Litwin, A. J. P. Klein-Szanto, S. Cheffetz, and M. Herlyn Antisense Cyclin D1 Induces Apoptosis and Tumor Shrinkage in Human Squamous Carcinomas Cancer Res., October 1, 1999; 59(19): 4876 - 4881. [Abstract] [Full Text] [PDF]
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 J. DOUKAS, D. K. HOGANSON, M. ONG, W. YING, D. L. LACEY, A. BAIRD, G. F. PIERCE, and B. A. SOSNOWSKI Retargeted delivery of adenoviral vectors through fibroblast growth factor receptors involves unique cellular pathways FASEB J, August 1, 1999; 13(11): 1459 - 1466. [Abstract] [Full Text]
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