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[Cancer Research 59, 5102-5105, October 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 5102-5105, October 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Antitumor Cytotoxicity Mediated by Ligand-activated Human V{alpha}24 NKT Cells1

Tetsu Kawano, Toshinori Nakayama, Noriaki Kamada, Yoshikatsu Kaneko, Michishige Harada, Nobutaka Ogura, Yasunori Akutsu, Shinichiro Motohashi, Toshihiko Iizasa, Hideharu Endo, Takehiko Fujisawa, Hiroshi Shinkai and Masaru Taniguchi2

Core Research for Evolutional Science and Technology Project and Department of Molecular Immunology, Graduate School of Medicine [T. K., T. N., N. K., Y. K., M. H., N. O., Y. A., S. M., M. T.], Department of Dermatology, School of Medicine [N. K., H. E., H. S.], and Department of Surgery, Institute of Pulmonary Cancer Research Center, School of Medicine [S. M., T. I., T. F.], Chiba University, Chiba 260-8670, Japan

Human V{alpha}24 NKT cells bearing an invariant V{alpha}24J{alpha}Q antigen receptor, the counterpart of the murine V{alpha}14 NKT cells, are activated by the specific ligand, {alpha}-galactosylceramide ({alpha}-GalCer) in a CD1d-dependent manner. Here, we demonstrate that the {alpha}-GalCer-activated V{alpha}24 NKT cells exert a potent perforin-dependent cytotoxic activity against a wide variety of human tumor cell lines. In addition, we demonstrate that V{alpha}24 NKT cells and dendritic cells (DCs) from melanoma patients are functionally normal, even in the tumor-bearing status. The potential use of {alpha}-GalCer-activated V{alpha}24 NKT cells and/or DCs from patients for cancer immunotherapy is discussed.




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