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[Cancer Research 59, 5264-5269, October 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 5264-5269, October 15, 1999]
© 1999 American Association for Cancer Research

Immunology

Regression of Established B16F10 Melanoma with a Recombinant Listeria monocytogenes Vaccine1

Zhen-Kun Pan, Larry M. Weiskirch and Yvonne Paterson2

Department of Microbiology and the University of Pennsylvania Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6076

We have previously shown that Listeria monocytogenes, a Gram-positive, facultative intracellular bacterium, is a potent vector for targeting tumor-specific antigens to the immune system. In the present study, we extend these studies to the highly tumorigenic mouse melanoma B16F10, transduced with a model tumor antigen. We are able to induce the regression of primary tumors and established lung metastases by parenteral immunization with a L. monocytogenes recombinant that expresses the same antigen. Adjunctive therapy with granulocyte macrophage colony-stimulating factor or a vaccinia-based vaccine does not result in an improved cure rate over the L. monocytogenes vaccine alone. Tumor regression is accompanied by the expression of inflammatory cytokines in the tumor.




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Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.