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The Nuclear Pore Complex Protein Nup88 Is Overexpressed in Tumor Cells¹

Deutsches Krebsforschungszentrum, 69120-Heidelberg, Germany (N. M., A. A.), and Departamentos de Enfermería I (M. D. M.), Inmunología, Microbiología y Parasitología (J. P.), y de Especialidades Médico-Quirúrgicas (N. M., J. S.), Facultad de Medicina y Odontología, Universidad del País Vasco, E-48940 Bilbao, Spain

It has been previously shown (J. Schneider et al., Br. J. Cancer, 77: 1015–1020, 1998) that an antibody directed against Candida albicans proteins (C6) recognizes specifically a protein in human ovarian tumors. We have now performed an immunoscreening of a human cDNA library using this antibody and identified the antigen as Nup88, a protein localized preferentially at the nuclear membrane and probably implicated in nucleocytoplasmic transport. Our results show that Nup88 is strongly expressed in a series of human tumor cell lines compared with nontransformed cell lines at the RNA and the protein levels. Furthermore, we observed that in 76% of 21 ovarian tumors analyzed, the protein is also overexpressed in malignant tissue when compared with healthy adjacent tissue. Nup88 may, therefore, be considered as a putative marker for tumor growth and is probably related to increased cell cycling.

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				V. E. Gould, N. Martinez, A. Orucevic, J. Schneider, and A. Alonso A Novel, Nuclear Pore-Associated, Widely Distributed Molecule Overexpressed in Oncogenesis and Development Am. J. Pathol., November 1, 2000; 157(5): 1605 - 1613. [Abstract] [Full Text] [PDF]