Cancer Research Meeting Calendar Telomeres
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 5488-5491, November 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gruber, A. D.
Right arrow Articles by Pauli, B. U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gruber, A. D.
Right arrow Articles by Pauli, B. U.
[Cancer Research 59, 5488-5491, November 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Tumorigenicity of Human Breast Cancer Is Associated with Loss of the Ca2+-activated Chloride Channel CLCA21

Achim D. Gruber and Bendicht U. Pauli2

Cancer Biology Laboratories, Department of Molecular Medicine, Cornell University College of Veterinary Medicine, Ithaca, New York 14853

The human Ca2+-activated chloride channel-2 (CLCA2) is expressed in normal breast epithelium but not in breast tumors of different stages of progression. Northern analysis of nontransformed and transformed breast epithelial cell lines revealed CLCA2 expression in the nontransformed cell line MCF10A and the nontumorigenic cell line MDA-MB-453, whereas all tumorigenic cell lines were negative (MDA-MB-231, MDA-MB-435, MDA-MB-468, and MCF7). When stably reintroduced into CLCA2-negative MDA-MB-231 and MDA-MB-435 cells, CLCA2 expression reduced Matrigel invasion in vitro and inducibility of s.c. and metastatic tumors of MDA-MB-231 cells in nude mice. Our results suggest that CLCA2 may act as a tumor suppressor in breast cancer.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
V. Walia, M. Ding, S. Kumar, D. Nie, L. S. Premkumar, and R. C. Elble
hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation
Cancer Res., August 15, 2009; 69(16): 6624 - 6632.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Song, X. Zhang, Z. Qi, G. Sun, S. Chi, Z. Zhu, J. Ren, Z. Qiu, K. Liu, L. Myatt, et al.
Cloning and Characterization of a Calcium-Activated Chloride Channel in Rat Uterus
Biol Reprod, April 1, 2009; 80(4): 788 - 794.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Zhao, L. Lu, N. Pokhriyal, H. Ma, L. Duan, S. Lin, N. Jafari, H. Band, and V. Band
Overexpression of RhoA Induces Preneoplastic Transformation of Primary Mammary Epithelial Cells
Cancer Res., January 15, 2009; 69(2): 483 - 491.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. C. Elble, V. Walia, H.-c. Cheng, C. J. Connon, L. Mundhenk, A. D. Gruber, and B. U. Pauli
The Putative Chloride Channel hCLCA2 Has a Single C-terminal Transmembrane Segment
J. Biol. Chem., October 6, 2006; 281(40): 29448 - 29454.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
P. Khalili, A. Arakelian, G. Chen, M. L. Plunkett, I. Beck, G. C. Parry, F. Donate, D. E. Shaw, A. P. Mazar, and S. A. Rabbani
A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo.
Mol. Cancer Ther., September 1, 2006; 5(9): 2271 - 2280.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. J. Holtzman, J. T. Battaile, and A. C. Patel
Immunogenetic Programs for Viral Induction of Mucous Cell Metaplasia
Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 29 - 39.
[Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
A. C. Patel, J. D. Morton, E. Y. Kim, Y. Alevy, S. Swanson, J. Tucker, G. Huang, E. Agapov, T. E. Phillips, M. E. Fuentes, et al.
Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members
Physiol Genomics, May 16, 2006; 25(3): 502 - 513.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Gibson, A. P. Lewis, K. Affleck, A. J. Aitken, E. Meldrum, and N. Thompson
hCLCA1 and mCLCA3 Are Secreted Non-integral Membrane Proteins and Therefore Are Not Ion Channels
J. Biol. Chem., July 22, 2005; 280(29): 27205 - 27212.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. E. Loewen and G. W. Forsyth
Structure and Function of CLCA Proteins
Physiol Rev, July 1, 2005; 85(3): 1061 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. R. Beckley, B. U. Pauli, and R. C. Elble
Re-expression of Detachment-inducible Chloride Channel mCLCA5 Suppresses Growth of Metastatic Breast Cancer Cells
J. Biol. Chem., October 1, 2004; 279(40): 41634 - 41641.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. R. Evans, W. B. Thoreson, and C. L. Beck
Molecular and Functional Analyses of Two New Calcium-activated Chloride Channel Family Members from Mouse Eye and Intestine
J. Biol. Chem., October 1, 2004; 279(40): 41792 - 41800.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
C. J. Connon, K. Yamasaki, S. Kawasaki, A. J. Quantock, N. Koizumi, and S. Kinoshita
Calcium-activated Chloride Channel-2 in Human Epithelia
J. Histochem. Cytochem., March 1, 2004; 52(3): 415 - 418.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Abdel-Ghany, H.-C. Cheng, R. C. Elble, H. Lin, J. DiBiasio, and B. U. Pauli
The Interacting Binding Domains of the {beta}4 Integrin and Calcium-activated Chloride Channels (CLCAs) in Metastasis
J. Biol. Chem., December 5, 2003; 278(49): 49406 - 49416.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Ronnov-Jessen, R. Villadsen, J. C. Edwards, and O. W. Petersen
Differential Expression of a Chloride Intracellular Channel Gene, CLIC4, in Transforming Growth Factor-{beta}1-Mediated Conversion of Fibroblasts to Myofibroblasts
Am. J. Pathol., August 1, 2002; 161(2): 471 - 480.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. C. Elble, G. Ji, K. Nehrke, J. DeBiasio, P. D. Kingsley, M. I. Kotlikoff, and B. U. Pauli
Molecular and Functional Characterization of a Murine Calcium-activated Chloride Channel Expressed in Smooth Muscle
J. Biol. Chem., May 17, 2002; 277(21): 18586 - 18591.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
T. J. Jentsch, V. Stein, F. Weinreich, and A. A. Zdebik
Molecular Structure and Physiological Function of Chloride Channels
Physiol Rev, April 1, 2002; 82(2): 503 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. C. Elble and B. U. Pauli
Tumor Suppression by a Proapoptotic Calcium-activated Chloride Channel in Mammary Epithelium
J. Biol. Chem., October 26, 2001; 276(44): 40510 - 40517.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.