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Strong Cytotoxic T Lymphocyte Responses to a Macrophage Inflammatory Protein 1-expressing Tumor: Linkage between Inflammation and Specific Immunity¹

Department of Pathology and Comprehensive Cancer Center, Ohio State University Medical Center, Columbus, Ohio 43210 [Y. L.], and Immunobiology Section, Yale University School of Medicine, New Haven, Connecticut 06510 [M. M.]

Leukocyte infiltration is an important histological sign of resistance to tumors. However, it is unclear whether local inflammatory responses can promote specific antitumor immunity. Here we report that local expression of macrophage inflammatory protein 1, which results in strong inflammation of leukocytes in tumors, leads to the induction of strong antitumor CTL responses. The induction of CTL effectors requires costimulatory molecules B7-1 and/or B7-2 on host antigen-presenting cells but not on the tumors. These results establish a critical linkage between inflammation and specific immunity.

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