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[Cancer Research 59, 5683-5686, November 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 5683-5686, November 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Alterations of the DR5/TRAIL Receptor 2 Gene in Non-Small Cell Lung Cancers1

Sug Hyung Lee2, Min Sun Shin2, Hong Sug Kim, Hun Kyung Lee, Won Sang Park, Su Young Kim, Jong Heun Lee, Seo Young Han, Jik Young Park, Ro Ra Oh, Ja June Jang, Ji Youn Han, Jung Young Lee and Nam Jin Yoo3

Departments of Pathology [S. H. L., M. S. S., H. S. K., H. K. L., W. S. P., S. Y. K., J. H. L., S. Y. H., J. Y. P., R. R. O., J. Y. L., N. J. Y.] and Internal Medicine [J. Y. H.], and Cancer Research Institute [S. H. L., W. S. P., J. Y. L., N. J. Y.], College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea; and Department of Pathology and Cancer Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea [J. J. J.]

Chromosome 8p21-22 is a frequent site of allelic deletions in many types of human tumors, including non-small cell lung cancer (NSCLC). Tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) is a cell-surface receptor involved in cell death signaling. The TRAIL-R2 gene recently has been mapped to chromosome 8p21-22. To explore the possibility that the TRAIL-R2 gene might be the relevant gene to the frequent deletion of 8p21-22 in NSCLC, we have analyzed the entire coding region and all splice sites of TRAIL-R2 for the detection of the somatic mutations in a series of 104 NSCLCs. Overall, 11 tumors (10.6%) were found to have TRAIL-R2 gene mutations in the death domain known to be involved in the transduction of an apoptotic signal. Our data indicate that somatic mutation of TRAIL-R2 may play a role in the pathogenesis of some NSCLCs and that the TRAIL-R2 gene is one of the genes relevant to the frequent loss of chromosome 8p21-22 in NSCLC.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
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Copyright © 1999 by the American Association for Cancer Research.