Cancer Research Annual Meeting 2010 Sign up for Cancer Research eTOC's
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 5737-5744, November 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsibris, J. C. M.
Right arrow Articles by Spellacy, W. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsibris, J. C. M.
Right arrow Articles by Spellacy, W. N.
[Cancer Research 59, 5737-5744, November 15, 1999]
© 1999 American Association for Cancer Research

Endocrinology

Human Uterine Leiomyomata Express Higher Levels of Peroxisome Proliferator-activated Receptor {gamma}, Retinoid X Receptor {alpha}, and all-trans Retinoic Acid Than Myometrium

John C. M. Tsibris1, Kathy B. Porter2, Allahyar Jazayeri2, Georg Tzimas3, Heinz Nau4, Hong Huang5, Khatuna Kuparadze6, Gregory W. Porter2, William F. O’Brien and William N. Spellacy

Departments of Obstetrics and Gynecology [J. C. M. T., K. B. P., A. J., H. H., K. K., G. W. P., W. F. O., W. N. S.] and Biochemistry and Molecular Biology [J. C. M. T.], University of South Florida, Tampa, Florida 33606, and Institute for Clinical Pharmacology and Toxicology, Free University of Berlin, D-14195 Berlin, Germany [G. T., H. N.]

Uterine leiomyomata are the main indication for a hysterectomy in the United States and occur in 25% of women >35 years. Because uterine leiomyomata can form when ovariectomized guinea pigs are exposed to estradiol and retinoic acids, we tested whether human leiomyomata had high levels of retinoic acids and related nuclear receptors. Compared with normal human myometrium, leiomyomata had 3- to 5-fold higher levels of peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}), retinoid X receptor {alpha} proteins, and all-trans retinoic acid, but only during the follicular phase of the menstrual cycle. 9-cis Retinoic acid was undetectable in either leiomyomata or myometrium. PPAR{gamma} mRNA levels were lower in leiomyomata than myometrium, but only during the luteal phase of the cycle. A PPAR{gamma} agonist, troglitazone, was given to guinea pigs along with estradiol and all-trans retinoic acid and produced the largest leiomyomata seen to date in this model. By contrast, no tumors formed when troglitazone was given alone or with estradiol or when troglitazone was given with estradiol and 9-cis retinoic acid. New therapies for human leiomyomata may emerge by combining antagonists for PPAR{gamma} and retinoid X receptor {alpha} with selective estrogen receptor modulators.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
J. S. Crabtree, S. A. Jelinsky, H. A. Harris, S. E. Choe, M. M. Cotreau, M. L. Kimberland, E. Wilson, K. A. Saraf, W. Liu, A. S. McCampbell, et al.
Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway
Cancer Res., August 1, 2009; 69(15): 6171 - 6178.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Zaitseva, B. J. Vollenhoven, and P. A.W. Rogers
Retinoids regulate genes involved in retinoic acid synthesis and transport in human myometrial and fibroid smooth muscle cells
Hum. Reprod., May 1, 2008; 23(5): 1076 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
D.-H. Nam, S. Ramachandran, D.-K. Song, K.-Y. Kwon, D.-S. Jeon, S.-J. Shin, S.-H. Kwon, S.-D. Cha, I. Bae, and C.-H. Cho
Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone
Mol. Hum. Reprod., November 1, 2007; 13(11): 829 - 836.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
M. Zaitseva, B. J. Vollenhoven, and P. A.W. Rogers
Retinoic acid pathway genes show significantly altered expression in uterine fibroids when compared with normal myometrium
Mol. Hum. Reprod., August 1, 2007; 13(8): 577 - 585.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Lattuada, P. Vigano, S. Mangioni, J. Sassone, S. Di Francesco, M. Vignali, and A. M. Di Blasio
Accumulation of Retinoid X Receptor-{alpha} in Uterine Leiomyomas Is Associated with a Delayed Ligand-Dependent Proteasome-Mediated Degradation and an Alteration of Its Transcriptional Activity
Mol. Endocrinol., March 1, 2007; 21(3): 602 - 612.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
A. J. Tyson-Capper, D. M.W. Cork, E. Wesley, E. A. Shiells, and A. D. Loughney
Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy
Mol. Hum. Reprod., November 1, 2006; 12(11): 695 - 701.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.-J. Wei, L. Chiriboga, A. A. Arslan, J. Melamed, H. Yee, and K. Mittal
Ethnic differences in expression of the dysregulated proteins in uterine leiomyomata
Hum. Reprod., January 1, 2006; 21(1): 57 - 67.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Mangioni, P. Vigano, D. Lattuada, A. Abbiati, M. Vignali, and A. M. Di Blasio
Overexpression of the Wnt5b Gene in Leiomyoma Cells: Implications for a Role of the Wnt Signaling Pathway in the Uterine Benign Tumor
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5349 - 5355.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
C.J. Loy, S. Evelyn, F.K. Lim, M.H. Liu, and E.L. Yong
Growth dynamics of human leiomyoma cells and inhibitory effects of the peroxisome proliferator-activated receptor-{gamma} ligand, pioglitazone
Mol. Hum. Reprod., August 1, 2005; 11(8): 561 - 566.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C. L. Walker and E. A. Stewart
Uterine Fibroids: The Elephant in the Room
Science, June 10, 2005; 308(5728): 1589 - 1592.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. A. Arslan, L. I. Gold, K. Mittal, T.-C. Suen, I. Belitskaya-Levy, M.-S. Tang, and P. Toniolo
Gene expression studies provide clues to the pathogenesis of uterine leiomyoma: new evidence and a systematic review
Hum. Reprod., April 1, 2005; 20(4): 852 - 863.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
B. Y. Kim, C.-H. Cho, D.-K. Song, K.-C. Mun, S.-I. Suh, S.-P. Kim, D.-H. Shin, B.-C. Jang, T. K. Kwon, S.-D. Cha, et al.
Ciglitizone inhibits cell proliferation in human uterine leiomyoma via activation of store-operated Ca2+ channels
Am J Physiol Cell Physiol, February 1, 2005; 288(2): C389 - C395.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. D. Houston, J. A. Copland, R. R. Broaddus, M. M. Gottardis, S. M. Fischer, and C. L. Walker
Inhibition of Proliferation and Estrogen Receptor Signaling by Peroxisome Proliferator-activated Receptor {gamma} Ligands in Uterine Leiomyoma
Cancer Res., March 15, 2003; 63(6): 1221 - 1227.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
X. Wu, A. Blanck, G. Norstedt, L. Sahlin, and A. Flores-Morales
Identification of genes with higher expression in human uterine leiomyomas than in the corresponding myometrium
Mol. Hum. Reprod., March 1, 2002; 8(3): 246 - 254.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.