This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Guha, C. Articles by Roy-Chowdhury, J. Search for Related Content PubMed PubMed Citation Articles by Guha, C. Articles by Roy-Chowdhury, J.

Amelioration of Radiation-induced Liver Damage in Partially Hepatectomized Rats by Hepatocyte Transplantation¹

Departments of Radiation Oncology [C. G., A. S., A. A., G. R. G., B. V.], Medicine [S. Gu., S. Ga., R. S., N. R-C., J. R-C.], Pathology [K. E. T.], and Molecular Genetics [N. R-C., J. R-C.] and The Marion Bessin Liver Research Center [S. Gu., S. Ga., R. S., N. R-C., J. R-C.], Albert Einstein College of Medicine, Bronx, New York 10461, and Department of Radiation Oncology, Beth Israel Medical Center, New York, New York [A. A.]

Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepatocytes would proliferate preferentially in a partially resected and irradiated liver, providing metabolic support. We subjected F344 rats to hepatic RT and partial hepatectomy with/without a single intrasplenic, syngeneic hepatocyte transplantation. Hepatocyte transplantation ameliorated radiation-induced liver damage and improved survival of rats receiving RT after partial hepatectomy. We further demonstrated that transplanted hepatocytes extensively repopulate and function in a heavily irradiated rat liver.

This article has been cited by other articles:

				F. Marongiu, S. Doratiotto, S. Montisci, P. Pani, and E. Laconi Liver Repopulation and Carcinogenesis: Two Sides of the Same Coin? Am. J. Pathol., April 1, 2008; 172(4): 857 - 864. [Abstract] [Full Text] [PDF]

				M. B. Herrera, S. Bruno, S. Buttiglieri, C. Tetta, S. Gatti, M. C. Deregibus, B. Bussolati, and G. Camussi Isolation and Characterization of a Stem Cell Population from Adult Human Liver Stem Cells, December 1, 2006; 24(12): 2840 - 2850. [Abstract] [Full Text] [PDF]

				M. Oertel, A. Menthena, Y.-Q. Chen, and D. A. Shafritz Properties of Cryopreserved Fetal Liver Stem/Progenitor Cells That Exhibit Long-Term Repopulation of the Normal Rat Liver Stem Cells, October 1, 2006; 24(10): 2244 - 2251. [Abstract] [Full Text] [PDF]

				R P Hill Radiation effects on the respiratory system Br. J. Radiol., January 1, 2005; Supplement_27(1): 75 - 81. [Abstract] [Full Text] [PDF]

				S. Masson, D. J. Harrison, J. N. Plevris, and P. N. Newsome Potential of Hematopoietic Stem Cell Therapy in Hepatology: A Critical Review Stem Cells, November 1, 2004; 22(6): 897 - 907. [Abstract] [Full Text] [PDF]

				P. G. Wells, P. I. Mackenzie, J. Roy Chowdhury, C. Guillemette, P. A. Gregory, Y. Ishii, A. J. Hansen, F. K. Kessler, P. M. Kim, N. Roy Chowdhury, et al. GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE Drug Metab. Dispos., March 1, 2004; 32(3): 281 - 290. [Abstract] [Full Text] [PDF]

				BASL abstracts Gut, May 1, 2003; 52(5): e1 - 31. [Full Text] [PDF]

				H. Malhi, G. R. Gorla, A. N. Irani, P. Annamaneni, and S. Gupta Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation PNAS, October 1, 2002; 99(20): 13114 - 13119. [Abstract] [Full Text] [PDF]

				G. R. Gorla, H. Malhi, and S. Gupta Polyploidy associated with oxidative injury attenuates proliferative potential of cells J. Cell Sci., March 10, 2002; 114(16): 2943 - 2951. [Abstract] [Full Text] [PDF]

				J. S. Sandhu, P. M. Petkov, M. D. Dabeva, and D. A. Shafritz Stem Cell Properties and Repopulation of the Rat Liver by Fetal Liver Epithelial Progenitor Cells Am. J. Pathol., October 1, 2001; 159(4): 1323 - 1334. [Abstract] [Full Text]

				S. Laconi, S. Pillai, P. Paolo Porcu, D. A. Shafritz, P. Pani, and E. Laconi Massive Liver Replacement by Transplanted Hepatocytes in the Absence of Exogenous Growth Stimuli in Rats Treated with Retrorsine Am. J. Pathol., February 1, 2001; 158(2): 771 - 777. [Abstract] [Full Text] [PDF]