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Sensitivity to Polyamine-induced Growth Arrest Correlates with Antizyme Induction in Prostate Carcinoma Cells

Departments of Cell Biology [B. R. Z.] and Surgery [C. K., D. T. C.], Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115

High local polyamine concentrations may suppress cell growth of primary prostatic carcinomas. When cell growth assays were conducted in defined serum-free medium, spermine inhibited the growth of poorly metastatic rat prostate carcinoma cells, causing cell cycle arrest in the G₁ phase. In contrast, highly metastatic prostate carcinoma cells were resistant to the growth inhibitory activity of spermine. Ornithine decarboxylase antizyme levels, measured by Western blotting, were elevated 1–2 h after spermine treatment of spermine-sensitive cells but not spermine-resistant cells. Spermine uptake was similar in both the sensitive and resistant cell lines. These results suggest that failure to induce antizyme correlates with spermine resistance in prostate carcinoma.

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