Cancer Research Annual Meeting 2010 Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 6205-6213, December 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morgan, J. A.
Right arrow Articles by Sklar, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morgan, J. A.
Right arrow Articles by Sklar, J.
[Cancer Research 59, 6205-6213, December 15, 1999]
© 1999 American Association for Cancer Research

Molecular Biology and Genetics

Breakpoints of the t(11;18)(q21;q21) in Mucosa-associated Lymphoid Tissue (MALT) Lymphoma Lie within or near the Previously Undescribed Gene MALT1 in Chromosome 181

Jeffrey A. Morgan2, Yi Yin2, Alexander D. Borowsky, Frank Kuo, Nicole Nourmand, Jason I. Koontz, Carol Reynolds, Lee Soreng, Constance A. Griffin, Fiona Graeme-Cook, Nancy L. Harris, Dennis Weisenburger, Geraldine S. Pinkus, Jonathan A. Fletcher and Jeffrey Sklar3

Division of Molecular Oncology, Department of Pathology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts 02115 [J. A. M., Y. Y., A. D. B., F. K., N. N., J. I. K., C. R., L. S., G. S. P., J. A. F., J. S.]; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114 [F. G-C., N. L. H.]; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 [C. A. G.]; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 [D. W.]

Lymphomas arising in mucosa-associated lymphoid tissue (MALT) are indolent B-cell tumors that have a predilection for epithelial sites and often develop in a setting of chronic inflammation or autoimmunity. As many as 50% of low-grade MALT lymphomas contain an (11;18)(q21;q21) chromosomal translocation. Using fluorescence in situ hybridization, we have analyzed the position of recombination within chromosome 18 DNA in three examples of MALT lymphoma bearing this translocation. In all three cases, the breakpoint maps to DNA in BAC b357H2, covering about 150 kb of sequence. A previously undescribed, ubiquitously expressed gene, which we refer to as MALT1, was identified within this sequence and was found to be broken in one case for which we have definitively located the position of recombination between chromosomes 18 and 11. The sequence of this gene indicates the presence of two immunoglobulin-like C2 domains and a region of partial homology to caspases, suggesting a possible role for MALT1 in the regulation of apoptosis.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
E. Braggio, J. J. Keats, X. Leleu, S. Van Wier, V. H. Jimenez-Zepeda, R. Valdez, R. F.J. Schop, T. Price-Troska, K. Henderson, A. Sacco, et al.
Identification of Copy Number Abnormalities and Inactivating Mutations in Two Negative Regulators of Nuclear Factor-{kappa}B Signaling Pathways in Waldenstrom's Macroglobulinemia
Cancer Res., April 15, 2009; 69(8): 3579 - 3588.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. R. McCully and J. L. Pomerantz
The Protein Kinase C-Responsive Inhibitory Domain of CARD11 Functions in NF-{kappa}B Activation To Regulate the Association of Multiple Signaling Cofactors That Differentially Depend on Bcl10 and MALT1 for Association
Mol. Cell. Biol., September 15, 2008; 28(18): 5668 - 5686.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
J. Dierlamm, E. M. Murga Penas, S. Bentink, S. Wessendorf, H. Berger, M. Hummel, W. Klapper, D. Lenze, A. Rosenwald, E. Haralambieva, et al.
Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma
Haematologica, May 1, 2008; 93(5): 688 - 696.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
C. M Bacon, M.-Q. Du, and A. Dogan
Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists
J. Clin. Pathol., April 1, 2007; 60(4): 361 - 372.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
E. M. Murga Penas, E. Callet-Bauchu, H. Ye, K. Hinz, N. Albert, C. Copie-Bergman, S. Gazzo, F. Berger, G. Salles, C. Bokemeyer, et al.
The translocations t(6;18;11)(q24;q21;q21) and t(11;14;18)(q21;q32;q21) lead to a fusion of the API2 and MALT1 genes and occur in MALT lymphomas
Haematologica, March 1, 2007; 92(3): 405 - 409.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
S. M. Cohen, M. Petryk, M. Varma, P. S. Kozuch, E. D. Ames, and M. L. Grossbard
Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue
Oncologist, November 1, 2006; 11(10): 1100 - 1117.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. Streubel, D. Huber, S. Wohrer, A. Chott, and M. Raderer
Reverse Transcription-PCR for t(11;18)(q21;q21) Staging and Monitoring in Mucosa-Associated Lymphoid Tissue Lymphoma.
Clin. Cancer Res., October 15, 2006; 12(20): 6023 - 6028.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Varfolomeev, S. M. Wayson, V. M. Dixit, W. J. Fairbrother, and D. Vucic
The Inhibitor of Apoptosis Protein Fusion c-IAP2{middle dot}MALT1 Stimulates NF-{kappa}B Activation Independently of TRAF1 AND TRAF2
J. Biol. Chem., September 29, 2006; 281(39): 29022 - 29029.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Decaudin, P. de Cremoux, A. Vincent-Salomon, R. Dendale, and L. L.-L. Rouic
Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options
Blood, September 1, 2006; 108(5): 1451 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
M-Q Du and J C Atherton
Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management.
Gut, June 1, 2006; 55(6): 886 - 893.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Samuel, K. Welsh, T. Lober, S. H. Togo, J. M. Zapata, and J. C. Reed
Distinct BIR Domains of cIAP1 Mediate Binding to and Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 2 and Second Mitochondrial Activator of Caspases
J. Biol. Chem., January 13, 2006; 281(2): 1080 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Nakagawa, Y. Hosokawa, M. Yonezumi, K. Izumiyama, R. Suzuki, S. Tsuzuki, M. Asaka, and M. Seto
MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10
Blood, December 15, 2005; 106(13): 4210 - 4216.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. Farinha and R. D. Gascoyne
Molecular Pathogenesis of Mucosa-Associated Lymphoid Tissue Lymphoma
J. Clin. Oncol., September 10, 2005; 23(26): 6370 - 6378.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Ho, R. E. Davis, B. Conne, R. Chappuis, M. Berczy, P. Mhawech, L. M. Staudt, and J. Schwaller
MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-{kappa}B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells
Blood, April 1, 2005; 105(7): 2891 - 2899.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R. Gerl and D. L. Vaux
Apoptosis in the development and treatment of cancer
Carcinogenesis, February 1, 2005; 26(2): 263 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Stoffel, M. Chaurushiya, B. Singh, and A. J. Levine
Activation of NF-{kappa}B and inhibition of p53-mediated apoptosis by API2/mucosa-associated lymphoid tissue 1 fusions promote oncogenesis
PNAS, June 15, 2004; 101(24): 9079 - 9084.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
O. T. Lynch and M. Gadina
Ubiquitination for Activation: New Directions in the NF-{kappa}B Roadmap
Mol. Interv., June 1, 2004; 4(3): 144 - 146.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Hosokawa, H. Suzuki, Y. Suzuki, R. Takahashi, and M. Seto
Antiapoptotic Function of Apoptosis Inhibitor 2-MALT1 Fusion Protein Involved in t(11;18)(q21;q21) Mucosa-Associated Lymphoid Tissue Lymphoma
Cancer Res., May 15, 2004; 64(10): 3452 - 3457.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Ghannam, A. Takeda, T. Camarata, M. A. Moore, A. Viale, and N. R. Yaseen
The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells
J. Biol. Chem., January 9, 2004; 279(2): 866 - 875.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
P. C. Lucas, L. M. McAllister-Lucas, and G. Nunez
NF-{kappa}B signaling in lymphocytes: a new cast of characters
J. Cell Sci., January 1, 2004; 117(1): 31 - 39.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. W. Tsang, M. K. Gospodarowicz, M. Pintilie, W. Wells, D. C. Hodgson, A. Sun, M. Crump, and B. J. Patterson
Localized Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy Has Excellent Clinical Outcome
J. Clin. Oncol., November 15, 2003; 21(22): 4157 - 4164.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Franchi, I. Condo, B. Tomassini, C. Nicolo, and R. Testi
A caspaselike activity is triggered by LPS and is required for survival of human dendritic cells
Blood, October 15, 2003; 102(8): 2910 - 2915.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. J. P. Huntly, A. Bench, and A. R. Green
Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemia
Blood, August 15, 2003; 102(4): 1160 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Sanchez-Izquierdo, G. Buchonnet, R. Siebert, R. D. Gascoyne, J. Climent, L. Karran, M. Marin, D. Blesa, D. Horsman, A. Rosenwald, et al.
MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma
Blood, June 1, 2003; 101(11): 4539 - 4546.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. Streubel, A. Lamprecht, J. Dierlamm, L. Cerroni, M. Stolte, G. Ott, M. Raderer, and A. Chott
T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma
Blood, March 15, 2003; 101(6): 2335 - 2339.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Inagaki, J. K. C. Chan, J. W. M. Ng, M. Okabe, T. Yoshino, M. Okamoto, H. Ogawa, H. Matsushita, T. Yokose, Y. Matsuno, et al.
Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features
Am. J. Pathol., April 1, 2002; 160(4): 1435 - 1443.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. Liu, H. Ye, A. Dogan, R. Ranaldi, R. A. Hamoudi, I. Bearzi, P. G. Isaacson, and M.-Q. Du
T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10
Blood, August 15, 2001; 98(4): 1182 - 1187.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. I. Koontz, A. L. Soreng, M. Nucci, F. C. Kuo, P. Pauwels, H. van den Berghe, P. D. Cin, J. A. Fletcher, and J. Sklar
Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors
PNAS, May 22, 2001; 98(11): 6348 - 6353.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
F. Cavalli, P. G. Isaacson, R. D. Gascoyne, and E. Zucca
MALT Lymphomas
Hematology, January 1, 2001; 2001(1): 241 - 258.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
E. Macintyre, D. Willerford, and S. W. Morris
Non-Hodgkin's Lymphoma: Molecular Features of B Cell Lymphoma
Hematology, January 1, 2000; 2000(1): 180 - 204.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. C. Lucas, M. Yonezumi, N. Inohara, L. M. McAllister-Lucas, M. E. Abazeed, F. F. Chen, S. Yamaoka, M. Seto, and G. Nunez
Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-kappa B Signaling Pathway
J. Biol. Chem., May 25, 2001; 276(22): 19012 - 19019.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. M. McAllister-Lucas, N. Inohara, P. C. Lucas, J. Ruland, A. Benito, Q. Li, S. Chen, F. F. Chen, S. Yamaoka, I. M. Verma, et al.
Bimp1, a MAGUK Family Member Linking Protein Kinase C Activation to Bcl10-mediated NF-kappa B Induction
J. Biol. Chem., August 10, 2001; 276(33): 30589 - 30597.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.