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[Cancer Research 59, 6205-6213, December 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 6205-6213, December 15, 1999]
© 1999 American Association for Cancer Research

Molecular Biology and Genetics

Breakpoints of the t(11;18)(q21;q21) in Mucosa-associated Lymphoid Tissue (MALT) Lymphoma Lie within or near the Previously Undescribed Gene MALT1 in Chromosome 181

Jeffrey A. Morgan2, Yi Yin2, Alexander D. Borowsky, Frank Kuo, Nicole Nourmand, Jason I. Koontz, Carol Reynolds, Lee Soreng, Constance A. Griffin, Fiona Graeme-Cook, Nancy L. Harris, Dennis Weisenburger, Geraldine S. Pinkus, Jonathan A. Fletcher and Jeffrey Sklar3

Division of Molecular Oncology, Department of Pathology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts 02115 [J. A. M., Y. Y., A. D. B., F. K., N. N., J. I. K., C. R., L. S., G. S. P., J. A. F., J. S.]; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114 [F. G-C., N. L. H.]; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 [C. A. G.]; and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 [D. W.]

Lymphomas arising in mucosa-associated lymphoid tissue (MALT) are indolent B-cell tumors that have a predilection for epithelial sites and often develop in a setting of chronic inflammation or autoimmunity. As many as 50% of low-grade MALT lymphomas contain an (11;18)(q21;q21) chromosomal translocation. Using fluorescence in situ hybridization, we have analyzed the position of recombination within chromosome 18 DNA in three examples of MALT lymphoma bearing this translocation. In all three cases, the breakpoint maps to DNA in BAC b357H2, covering about 150 kb of sequence. A previously undescribed, ubiquitously expressed gene, which we refer to as MALT1, was identified within this sequence and was found to be broken in one case for which we have definitively located the position of recombination between chromosomes 18 and 11. The sequence of this gene indicates the presence of two immunoglobulin-like C2 domains and a region of partial homology to caspases, suggesting a possible role for MALT1 in the regulation of apoptosis.




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Copyright © 1999 by the American Association for Cancer Research.