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[Cancer Research 59, 529-532, February 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 529-532, February 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Estrogen Receptor-ß Messenger RNA Expression in Human Breast Tumor Biopsies

Relationship to Steroid Receptor Status and Regulation by Progestins1

Helmut Dotzlaw, Etienne Leygue, Peter H. Watson and Leigh C. Murphy2

Departments of Biochemistry and Molecular Biology [H. D., E. L., L. C. M.] and Pathology [P. H. W.], Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3 Canada

When the level of estrogen receptor (ER)-ß mRNA in tumors, determined by reverse transcription-PCR, was assessed according to either ER status or PR status alone, determined by ligand binding assays, the level of ER-ß mRNA was significantly lower in PR+ tumors compared with PR-tumors (P = 0.036), and no association with ER status was found. Subgroup analysis showed that ER-ß mRNA expression in ER+/PR+ breast tumors was significantly less than in ER+/PR- (P = 0.009), ER-/PR+ (P = 0.029), and ER-/PR- (P = 0.023) groups. Interestingly, the ER-ß mRNA expression was specifically decreased by progestin in T-47D breast cancer cells. The data suggest the possibility that expression of ER-ß in human breast tumors is a marker of endocrine therapy responsiveness.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
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Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.