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[Cancer Research 59, 542-546, February 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 542-546, February 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Phosphoinositide 3-Kinase Activity Is Essential for all-trans-Retinoic Acid-induced Granulocytic Differentiation of HL-60 Cells1

Valeria Bertagnolo, Luca Maria Neri, Marco Marchisio, Carlo Mischiati and Silvano Capitani2

Signal Transduction Unit/Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Ferrara 44100 [V. B., L. M. N., M. M., C. M., S. C.]; and Consiglio Nazionale delle Ricerche Institute of Cytomorphology, Bologna 40100 [L. M. N.], Italy

Phosphoinositide 3-kinase (PI 3-K) activity increases in HL-60 cells that are induced to granulocytic differentiation by all-trans-retinoic acid. Immunochemical and immunocytochemical analyses by confocal microscopy also reveal an increase in the amount of the enzyme, which is particularly evident at the nuclear level. Inhibition of PI 3-K activity by nanomolar concentrations of wortmannin and of its expression by transfection with an antisense fragment of p85{alpha} prevented the differentiative process. The data obtained indicate that PI 3-K activity plays an essential role in promoting granulocytic differentiation.




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Copyright © 1999 by the American Association for Cancer Research.