Cancer Research AACR Legacy Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 711-719, February 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, J. Y. H.
Right arrow Articles by Pomeroy, S. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, J. Y. H.
Right arrow Articles by Pomeroy, S. L.
[Cancer Research 59, 711-719, February 1, 1999]
© 1999 American Association for Cancer Research

Tumor Biology

Activation of Neurotrophin-3 Receptor TrkC Induces Apoptosis in Medulloblastomas1

John Y. H. Kim, Mary E. Sutton, Diane J. Lu, Tracey A. Cho, Liliana C. Goumnerova, Lyuda Goritchenko, Jill R. Kaufman, K. K. Lam, Amy L. Billet, Nancy J. Tarbell, Julian Wu, Jeffrey C. Allen, Charles D. Stiles, Rosalind A. Segal and Scott L. Pomeroy2

Division of Neuroscience, Department of Neurology [J. Y. H. K., M. E. S., D. J. L., T. A. C., J. R. K., K. K. L., S. L. P.] and Department of Neurosurgery [L. C. G., L. G.], Children’s Hospital; Departments of Neurology [R. A. S.] and Surgery [J. W.], Division of Neurosurgery, The Brain Tumor Center, Beth Israel/Deaconess Medical Center; Departments of Pediatric Hematology-Oncology [J. Y. H. K., A. L. B.] and Microbiology and Molecular Genetics [C. D. S.], Dana-Farber Cancer Institute; and Division of Radiation Oncology, Massachusetts General Hospital [N. J. T.], Harvard Medical School, Boston, Massachusetts 02115; Department of Neurosurgery, New England Medical Center, Tufts School of Medicine, Boston, Massachusetts 02111 [J. W.]; and Division of Neuro-oncology, New York University Medical Center, New York, New York 10016 [J. C. A.]

Elevated expression of the neurotrophin-3 (NT-3) receptor TrkC by childhood medulloblastomas is associated with favorable clinical outcome. Here, we provide evidence that TrkC is more than simply a passive marker of prognosis. We demonstrate that: (a) medulloblastomas undergo apoptosis in vitro when grown in the presence of NT-3; (b) overexpression of TrkC inhibits the growth of intracerebral xenografts of a medulloblastoma cell line in nude mice; and (c) trkC expression by individual tumor cells is highly correlated with apoptosis within primary medulloblastoma biopsy specimens. TrkC-mediated NT-3 signaling promotes apoptosis by activating multiple parallel signaling pathways and by inducing immediate-early gene expression of both c-jun and c-fos. Considered collectively, these results support the conclusion that the biological actions of TrkC activation affect medulloblastoma outcome by inhibiting tumor growth through the promotion of apoptosis.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
A. Rossi, V. Caracciolo, G. Russo, K. Reiss, and A. Giordano
Medulloblastoma: From Molecular Pathology to Therapy
Clin. Cancer Res., February 15, 2008; 14(4): 971 - 976.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Tauszig-Delamasure, L.-Y. Yu, J. R. Cabrera, J. Bouzas-Rodriguez, C. Mermet-Bouvier, C. Guix, M.-C. Bordeaux, U. Arumae, and P. Mehlen
The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm
PNAS, August 14, 2007; 104(33): 13361 - 13366.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Rutkowski, A. von Bueren, K. von Hoff, W. Hartmann, T. Shalaby, F. Deinlein, M. Warmuth-Metz, N. Soerensen, A. Emser, U. Bode, et al.
Prognostic Relevance of Clinical and Biological Risk Factors in Childhood Medulloblastoma: Results of Patients Treated in the Prospective Multicenter Trial HIT'91
Clin. Cancer Res., May 1, 2007; 13(9): 2651 - 2657.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Li, B. Lal, S. Kwon, X. Fan, U. Saldanha, T. E. Reznik, E. B. Kuchner, C. Eberhart, J. Laterra, and R. Abounader
The Scatter Factor/Hepatocyte Growth Factor: c-Met Pathway in Human Embryonal Central Nervous System Tumor Malignancy
Cancer Res., October 15, 2005; 65(20): 9355 - 9362.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L.-M. Sturla, C. W. Cowan, L. Guenther, R. C. Castellino, J. Y.H. Kim, and S. L. Pomeroy
A Novel Role for Extracellular Signal-Regulated Kinase 5 and Myocyte Enhancer Factor 2 in Medulloblastoma Cell Death
Cancer Res., July 1, 2005; 65(13): 5683 - 5689.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Pan, M. Pellarin, E. Holmes, I. Smirnov, A. Misra, C. G. Eberhart, P. C. Burger, J. A. Biegel, and B. G. Feuerstein
Isochromosome 17q Is a Negative Prognostic Factor in Poor-Risk Childhood Medulloblastoma Patients
Clin. Cancer Res., July 1, 2005; 11(13): 4733 - 4740.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. G. Astrakas, D. Zurakowski, A. A. Tzika, M. K. Zarifi, D. C. Anthony, U. De Girolami, N. J. Tarbell, and P. M. Black
Noninvasive Magnetic Resonance Spectroscopic Imaging Biomarkers to Predict the Clinical Grade of Pediatric Brain Tumors
Clin. Cancer Res., December 15, 2004; 10(24): 8220 - 8228.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. Fernandez-Teijeiro, R. A. Betensky, L. M. Sturla, J. Y.H. Kim, P. Tamayo, and S. L. Pomeroy
Combining Gene Expression Profiles and Clinical Parameters for Risk Stratification in Medulloblastomas
J. Clin. Oncol., March 15, 2004; 22(6): 994 - 998.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. Gajjar, R. Hernan, M. Kocak, C. Fuller, Y. Lee, P. J. McKinnon, D. Wallace, C. Lau, M. Chintagumpala, D. M. Ashley, et al.
Clinical, Histopathologic, and Molecular Markers of Prognosis: Toward a New Disease Risk Stratification System for Medulloblastoma
J. Clin. Oncol., March 15, 2004; 22(6): 984 - 993.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. G. Fisher, P. C. Burger, and C. G. Eberhart
Biologic Risk Stratification of Medulloblastoma: The Real Time Is Now
J. Clin. Oncol., March 15, 2004; 22(6): 971 - 974.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
W. Q. Yang, D. Senger, H. Muzik, Z. Q. Shi, D. Johnson, P. M. A. Brasher, N. B. Rewcastle, M. Hamilton, J. Rutka, J. Wolff, et al.
Reovirus Prolongs Survival and Reduces the Frequency of Spinal and Leptomeningeal Metastases from Medulloblastoma
Cancer Res., June 15, 2003; 63(12): 3162 - 3172.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
T. J. MacDonald, B. R. Rood, M. R. Santi, G. Vezina, K. Bingaman, P. H. Cogen, and R. J. Packer
Advances in the Diagnosis, Molecular Genetics, and Treatment of Pediatric Embryonal CNS Tumors
Oncologist, April 1, 2003; 8(2): 174 - 186.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Luis Del Valle, S. Enam, A. Lassak, J. Y. Wang, S. Croul, K. Khalili, and K. Reiss
Insulin-like Growth Factor I Receptor Activity in Human Medulloblastomas
Clin. Cancer Res., June 1, 2002; 8(6): 1822 - 1830.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. Yan, Y. Liang, K. D. Nylander, J. Wong, R. M. Rudavsky, H. U. Saragovi, and N. F. Schor
p75-Nerve Growth Factor as an Antiapoptotic Complex: Independence versus Cooperativity in Protection from Enediyne Chemotherapeutic Agents
Mol. Pharmacol., April 1, 2002; 61(4): 710 - 719.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. M. Duplan, Y. Theoret, and R. Kenigsberg
Antitumor Activity of Fibroblast Growth Factors (FGFs) for Medulloblastoma May Correlate with FGF Receptor Expression and Tumor Variant
Clin. Cancer Res., January 1, 2002; 8(1): 246 - 257.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Kyin, Y. Hua, M. Baybis, B. Scheithauer, D. Kolson, E. Uhlmann, D. Gutmann, and P. B. Crino
Differential Cellular Expression of Neurotrophins in Cortical Tubers of the Tuberous Sclerosis Complex
Am. J. Pathol., October 1, 2001; 159(4): 1541 - 1554.
[Abstract] [Full Text]

Home page
 Clin. Cancer Res.Home page
M. A. Grotzer, M. D. Hogarty, A. J. Janss, X. Liu, H. Zhao, A. Eggert, L. N. Sutton, L. B. Rorke, G. M. Brodeur, and P. C. Phillips
MYC Messenger RNA Expression Predicts Survival Outcome in Childhood Primitive Neuroectodermal Tumor/Medulloblastoma
Clin. Cancer Res., August 1, 2001; 7(8): 2425 - 2433.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. M. Giehl, S. Rohrig, H. Bonatz, M. Gutjahr, B. Leiner, I. Bartke, Q. Yan, L. F. Reichardt, C. Backus, A. A. Welcher, et al.
Endogenous Brain-Derived Neurotrophic Factor and Neurotrophin-3 Antagonistically Regulate Survival of Axotomized Corticospinal Neurons In Vivo
J. Neurosci., May 15, 2001; 21(10): 3492 - 3502.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. Y.P. Lam and X. O. Breakefield
Potential of gene therapy for brain tumors
Hum. Mol. Genet., April 1, 2001; 10(7): 777 - 787.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Wagner, K. D. Wagner, M. Sefton, A. Rodríguez–Tébar, and R. Grantyn
An Abnormal Response of Retinoblastoma Cells (Y-79) to Neurotrophins
Invest. Ophthalmol. Vis. Sci., June 1, 2000; 41(7): 1932 - 1939.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
T. T. Chou, J. Q. Trojanowski, and V. M.-Y. Lee
A Novel Apoptotic Pathway Induced by Nerve Growth Factor-mediated TrkA Activation in Medulloblastoma
J. Biol. Chem., January 7, 2000; 275(1): 565 - 570.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. T. Chou, J. Q. Trojanowski, and V. M.-Y. Lee
p38 Mitogen-activated Protein Kinase-independent Induction of gadd45 Expression in Nerve Growth Factor-induced Apoptosis in Medulloblastomas
J. Biol. Chem., October 26, 2001; 276(44): 41120 - 41127.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.