Cancer Research AACR Conference on Molecular Diagnostics Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
[Cancer Research 59, 771-775, February 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheo, D. L.
Right arrow Articles by Friedberg, E. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheo, D. L.
Right arrow Articles by Friedberg, E. C.
[Cancer Research 59, 771-775, February 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Mutational Inactivation of the Xeroderma Pigmentosum Group C Gene Confers Predisposition to 2-Acetylaminofluorene-induced Liver and Lung Cancer and to Spontaneous Testicular Cancer in Trp53-/- Mice1

David L. Cheo, Dennis K. Burns, Lisiane B. Meira, Jean Francois Houle and Errol C. Friedberg2

Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75235

Mice that are genetically engineered to mimic the human hereditary cancer-prone DNA repair-defective disease xeroderma pigmentosum (XP) are highly predisposed to UV radiation-induced skin cancer. It is not clear, however, whether XP mice or humans are predisposed to cancers in other tissues associated with exposure to environmental carcinogens. To test the importance of nucleotide excision repair in protection against chemical carcinogenesis in internal organs, we treated XPC mutant (XPC-/-) mice with 2-acetylaminofluorene and NOH-2-acetylaminofluorene. We observed a significantly higher incidence of chemically induced liver and lung tumors in XPC-/- mice compared with normal and heterozygous littermates. In addition, the progression of liver tumors in XPC-/- Trp53+/- mice is accelerated compared with XPC-/- Trp53+/+ animals. Finally, we demonstrate a higher incidence of spontaneous testicular tumors in XPC-/- Trp53-/- double mutant mice compared with XPC+/+ Trp53-/- mice.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
J. P.M. Melis, S. W.P. Wijnhoven, R. B. Beems, M. Roodbergen, J. van den Berg, H. Moon, E. Friedberg, G. T.J. van der Horst, J. H.J. Hoeijmakers, J. Vijg, et al.
Mouse Models for Xeroderma Pigmentosum Group A and Group C Show Divergent Cancer Phenotypes
Cancer Res., March 1, 2008; 68(5): 1347 - 1353.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. C. Hollander, R. T. Philburn, A. D. Patterson, S. Velasco-Miguel, E. C. Friedberg, R. I. Linnoila, and A. J. Fornace Jr.
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis
PNAS, September 13, 2005; 102(37): 13200 - 13205.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. M. Hoogervorst, C. Th. M. van Oostrom, R. B. Beems, J. van Benthem, S. Gielis, J. P. Vermeulen, P. W. Wester, J. G. Vos, A. de Vries, and H. van Steeg
p53 Heterozygosity Results in an Increased 2-Acetylaminofluorene-Induced Urinary Bladder but not Liver Tumor Response in DNA Repair-Deficient Xpa Mice
Cancer Res., August 1, 2004; 64(15): 5118 - 5126.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
G. Wang, L. Chuang, X. Zhang, S. Colton, A. Dombkowski, J. Reiners, A. Diakiw, and X. S. Xu
The initiative role of XPC protein in cisplatin DNA damaging treatment-mediated cell cycle regulation
Nucleic Acids Res., April 23, 2004; 32(7): 2231 - 2240.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Z. Chen, X. S. Xu, J. Yang, and G. Wang
Defining the function of XPC protein in psoralen and cisplatin-mediated DNA repair and mutagenesis
Carcinogenesis, June 1, 2003; 24(6): 1111 - 1121.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. R. Seo, M. R. Kelley, and M. L. Smith
From the Cover: Selenomethionine regulation of p53 by a ref1-dependent redox mechanism
PNAS, October 29, 2002; 99(22): 14548 - 14553.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. Sekine, H. Nagata, S. Tsuji, Y. Hirai, S. Fujimoto, M. Hatae, I. Kobayashi, T. Fujii, I. Nagata, K. Ushijima, et al.
Localization of a novel susceptibility gene for familial ovarian cancer to chromosome 3p22-p25
Hum. Mol. Genet., June 1, 2001; 10(13): 1421 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
F. Ide, H. Oda, Y. Nakatsuru, K. Kusama, H. Sakashita, K. Tanaka, and T. Ishikawa
Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline 1-oxide-induced tongue carcinogenesis
Carcinogenesis, April 1, 2001; 22(4): 567 - 572.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. C. Friedberg
Nucleotide Excision Repair and Cancer Predisposition : A Journey from Man to Yeast to Mice
Am. J. Pathol., September 1, 2000; 157(3): 693 - 701.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
F. Ide, N. Iida, Y. Nakatsuru, H. Oda, K. Tanaka, and T. Ishikawa
Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors
Carcinogenesis, June 1, 2000; 21(6): 1263 - 1265.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. L. Cheo, L. B. Meira, D. K. Burns, A. M. Reis, T. Issac, and E. C. Friedberg
Ultraviolet B Radiation-induced Skin Cancer in Mice Defective in the Xpc, Trp53, and Apex (HAP1) Genes: Genotype-specific Effects on Cancer Predisposition and Pathology of Tumors
Cancer Res., March 1, 2000; 60(6): 1580 - 1584.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 1999 by the American Association for Cancer Research.