Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 803-806, February 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bubendorf, L.
Right arrow Articles by Kallioniemi, O.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bubendorf, L.
Right arrow Articles by Kallioniemi, O.-P.
[Cancer Research 59, 803-806, February 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Survey of Gene Amplifications during Prostate Cancer Progression by High-Throughput Fluorescence in Situ Hybridization on Tissue Microarrays1

Lukas Bubendorf, Juha Kononen, Pasi Koivisto, Peter Schraml, Holger Moch, Thomas C. Gasser, Niels Willi, Michael J. Mihatsch, Guido Sauter and Olli-P. Kallioniemi2

Laboratory of Cancer Genetics, National Human Genome Research Institute, NIH [L. B., J. K., O-P. K.], Bethesda, Maryland 20892-4470; Laboratory of Cancer Genetics, Tampere University Hospital, 33521 Tampere, Finland [P. K.]; and Institute for Pathology [P. S., H. M., N. W., M. J. M., G. S.] and Urologic Clinics [T. C. G.], University of Basel, CH-4003 Basel, Switzerland

Prostate cancer development and progression is driven by the accumulation of genetic changes, the nature of which remains incompletely understood. To facilitate high-throughput analysis of molecular events taking place in primary, recurrent, and metastatic prostate cancer, we constructed a tissue microarray containing small 0.6-mm cylindrical samples acquired from 371 formalin-fixed blocks, including benign prostatic hyperplasia (n = 32) and primary tumors (n = 223), as well as both locally recurrent tumors (n = 54) and metastases (n = 62) from patients with hormone-refractory disease. Fluorescence in situ hybridization (FISH) was applied to the analysis of consecutive tissue microarray sections with probes for five different genes. High-level (>=3X) amplifications were very rare (<2%) in primary prostate cancers. However, in metastases from patients with hormone-refractory disease, amplification of the androgen receptor gene was seen in 22%, MYC in 11%, and Cyclin-D1 in 5% of the cases. In specimens from locally recurrent tumors, the corresponding percentages were 23, 4, and 8%. ERBB2 and NMYC amplifications were never detected at any stage of prostate cancer progression. In conclusion, FISH to tissue microarray sections enables high-throughput analysis of genetic alterations contributing to cancer development and progression. Our results implicate a role for amplification of androgen receptor in hormonal therapy failure and that of MYC in the metastatic progression of human prostate cancer.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
I. N. Holcomb, D. I. Grove, M. Kinnunen, C. L. Friedman, I. S. Gallaher, T. M. Morgan, C. L. Sather, J. J. Delrow, P. S. Nelson, P. H. Lange, et al.
Genomic Alterations Indicate Tumor Origin and Varied Metastatic Potential of Disseminated Cells from Prostate Cancer Patients
Cancer Res., July 15, 2008; 68(14): 5599 - 5608.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
H. Sugimura
Detection of chromosome changes in pathology archives: an application of microwave-assisted fluorescence in situ hybridization to human carcinogenesis studies
Carcinogenesis, April 1, 2008; 29(4): 681 - 687.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Schlomm, P. Kirstein, L. Iwers, B. Daniel, T. Steuber, J. Walz, F. H.K. Chun, A. Haese, J. Kollermann, M. Graefen, et al.
Clinical Significance of Epidermal Growth Factor Receptor Protein Overexpression and Gene Copy Number Gains in Prostate Cancer
Clin. Cancer Res., November 15, 2007; 13(22): 6579 - 6584.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. He, O. E. Franco, M. Jiang, K. Williams, H. D. Love, I. M. Coleman, P. S. Nelson, and S. W. Hayward
Tissue-Specific Consequences of Cyclin D1 Overexpression in Prostate Cancer Progression
Cancer Res., September 1, 2007; 67(17): 8188 - 8197.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. A. Mostaghel, S. T. Page, D. W. Lin, L. Fazli, I. M. Coleman, L. D. True, B. Knudsen, D. L. Hess, C. C. Nelson, A. M. Matsumoto, et al.
Intraprostatic Androgens and Androgen-Regulated Gene Expression Persist after Testosterone Suppression: Therapeutic Implications for Castration-Resistant Prostate Cancer
Cancer Res., May 15, 2007; 67(10): 5033 - 5041.
[Abstract] [Full Text] [PDF]

Home page
 Stat Methods Med ResHome page
Yulan Liang, A. Kelemen, and B. Tayo
Model-based or algorithm-based? Statistical evidence for diabetes and treatments using gene expression
Statistical Methods in Medical Research, April 1, 2007; 16(2): 139 - 153.
[Abstract] [PDF]

Home page
 Clin. Cancer Res.Home page
D. R. Shaffer, M. A. Leversha, D. C. Danila, O. Lin, R. Gonzalez-Espinoza, B. Gu, A. Anand, K. Smith, P. Maslak, G. V. Doyle, et al.
Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate Cancer
Clin. Cancer Res., April 1, 2007; 13(7): 2023 - 2029.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
A. Zimpfer, S. Schonberg, A. Lugli, C. Agostinelli, S. A Pileri, P. Went, and S. Dirnhofer
Construction and validation of a bone marrow tissue microarray
J. Clin. Pathol., January 1, 2007; 60(1): 57 - 61.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
F. Bertucci, D. Birnbaum, and A. Goncalves
Proteomics of Breast Cancer: Principles and Potential Clinical Applications
Mol. Cell. Proteomics, October 1, 2006; 5(10): 1772 - 1786.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Savic, K. Glatz, R. Schoenegg, P. Spieler, G. Feichter, M. Tamm, and L. Bubendorf
Multitarget Fluorescence In Situ Hybridization Elucidates Equivocal Lung Cytology
Chest, June 1, 2006; 129(6): 1629 - 1635.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
F. Mendrzyk, B. Radlwimmer, S. Joos, F. Kokocinski, A. Benner, D. E. Stange, K. Neben, H. Fiegler, N. P. Carter, G. Reifenberger, et al.
Genomic and Protein Expression Profiling Identifies CDK6 As Novel Independent Prognostic Marker in Medulloblastoma
J. Clin. Oncol., December 1, 2005; 23(34): 8853 - 8862.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Duff and I. J. McEwan
Mutation of Histidine 874 in the Androgen Receptor Ligand-Binding Domain Leads to Promiscuous Ligand Activation and Altered p160 Coactivator Interactions
Mol. Endocrinol., December 1, 2005; 19(12): 2943 - 2954.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. I. Scher and C. L. Sawyers
Biology of Progressive, Castration-Resistant Prostate Cancer: Directed Therapies Targeting the Androgen-Receptor Signaling Axis
J. Clin. Oncol., November 10, 2005; 23(32): 8253 - 8261.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
P. R. Nambiar, S. R. Boutin, R. Raja, and D. W. Rosenberg
Global Gene Expression Profiling: A Complement to Conventional Histopathologic Analysis of Neoplasia
Vet. Pathol., November 1, 2005; 42(6): 735 - 752.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
C Hughes, A Murphy, C Martin, O Sheils, and J O'Leary
Molecular pathology of prostate cancer
J. Clin. Pathol., July 1, 2005; 58(7): 673 - 684.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
H. I Scher, G. Buchanan, W. Gerald, L. M Butler, and W. D Tilley
Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer
Endocr. Relat. Cancer, September 1, 2004; 11(3): 459 - 476.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
R. Foley, D. Hollywood, and M. Lawler
Molecular pathology of prostate cancer: the key to identifying new biomarkers of disease
Endocr. Relat. Cancer, September 1, 2004; 11(3): 477 - 488.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. M. Velasco, K. A. Gillis, Y. Li, E. L. Brown, T. M. Sadler, M. Achilleos, L. M. Greenberger, P. Frost, W. Bai, and Y. Zhang
Identification and Validation of Novel Androgen-Regulated Genes in Prostate Cancer
Endocrinology, August 1, 2004; 145(8): 3913 - 3924.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. A. Rubin, S. Varambally, R. Beroukhim, S. A. Tomlins, D. R. Rhodes, P. L. Paris, M. D. Hofer, M. Storz-Schweizer, R. Kuefer, J. A. Fletcher, et al.
Overexpression, Amplification, and Androgen Regulation of TPD52 in Prostate Cancer
Cancer Res., June 1, 2004; 64(11): 3814 - 3822.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Neben, A. Korshunov, A. Benner, G. Wrobel, M. Hahn, F. Kokocinski, A. Golanov, S. Joos, and P. Lichter
Microarray-Based Screening for Molecular Markers in Medulloblastoma Revealed STK15 as Independent Predictor for Survival
Cancer Res., May 1, 2004; 64(9): 3103 - 3111.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. A. Heinlein and C. Chang
Androgen Receptor in Prostate Cancer
Endocr. Rev., April 1, 2004; 25(2): 276 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Struckmann, P. Schraml, R. Simon, K. Elmenhorst, M. Mirlacher, J. Kononen, and H. Moch
Impaired Expression of the Cell Cycle Regulator BTG2 Is Common in Clear Cell Renal Cell Carcinoma
Cancer Res., March 1, 2004; 64(5): 1632 - 1638.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Simon, S. Panussis, R. Maurer, H. Spichtin, K. Glatz, C. Tapia, M. Mirlacher, A. Rufle, J. Torhorst, and G. Sauter
KIT (CD117)-Positive Breast Cancers Are Infrequent and Lack KIT Gene Mutations
Clin. Cancer Res., January 1, 2004; 10(1): 178 - 183.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. K. Lee and C. Chang
Expression and Degradation of Androgen Receptor: Mechanism and Clinical Implication
J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4043 - 4054.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
H. Vrolijk, W. Sloos, W. Mesker, P. Franken, R. Fodde, H. Morreau, and H. Tanke
Automated Acquisition of Stained Tissue Microarrays for High-Throughput Evaluation of Molecular Targets
J. Mol. Diagn., August 1, 2003; 5(3): 160 - 167.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. J. Duggan, J. J. McKnight, K. E. Williamson, M. Loughrey, D. O'Rourke, P. W. Hamilton, S. R. Johnston, C. C. Schulman, and A. R. Zlotta
The Need to Embrace Molecular Profiling of Tumor Cells in Prostate and Bladder Cancer
Clin. Cancer Res., April 1, 2003; 9(4): 1240 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Freier, S. Joos, C. Flechtenmacher, F. Devens, A. Benner, F. X. Bosch, P. Lichter, and C. Hofele
Tissue Microarray Analysis Reveals Site-specific Prevalence of Oncogene Amplifications in Head and Neck Squamous Cell Carcinoma
Cancer Res., March 15, 2003; 63(6): 1179 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
M. Varella-Garcia
Molecular Cytogenetics in Solid Tumors: Laboratorial Tool for Diagnosis, Prognosis, and Therapy
Oncologist, February 1, 2003; 8(1): 45 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Kumar-Sinha, K. W. Ignatoski, M. E. Lippman, S. P. Ethier, and A. M. Chinnaiyan
Transcriptome Analysis of HER2 Reveals a Molecular Connection to Fatty Acid Synthesis
Cancer Res., January 1, 2003; 63(1): 132 - 139.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Bar-Shira, J. H. Pinthus, U. Rozovsky, M. Goldstein, W. R. Sellers, Y. Yaron, Z. Eshhar, and A. Orr-Urtreger
Multiple Genes in Human 20q13 Chromosomal Region Are Involved in an Advanced Prostate Cancer Xenograft
Cancer Res., December 1, 2002; 62(23): 6803 - 6807.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. G. Tepper, D. L. Boucher, P. E. Ryan, A.-H. Ma, L. Xia, L.-F. Lee, T. G. Pretlow, and H.-J. Kung
Characterization of a Novel Androgen Receptor Mutation in a Relapsed CWR22 Prostate Cancer Xenograft and Cell Line
Cancer Res., November 15, 2002; 62(22): 6606 - 6614.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. J. Urist, C. J. Di Como, M.-L. Lu, E. Charytonowicz, D. Verbel, C. P. Crum, T. A. Ince, F. D. McKeon, and C. Cordon-Cardo
Loss of p63 Expression Is Associated with Tumor Progression in Bladder Cancer
Am. J. Pathol., October 1, 2002; 161(4): 1199 - 1206.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. Mohr, G. D. Leikauf, G. Keith, and B. H. Rihn
Microarrays as Cancer Keys: An Array of Possibilities
J. Clin. Oncol., July 15, 2002; 20(14): 3165 - 3175.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. P. Massion, W.-L. Kuo, D. Stokoe, A. B. Olshen, P. A. Treseler, K. Chin, C. Chen, D. Polikoff, A. N. Jain, D. Pinkel, et al.
Genomic Copy Number Analysis of Non-small Cell Lung Cancer Using Array Comparative Genomic Hybridization: Implications of the Phosphatidylinositol 3-Kinase Pathway
Cancer Res., July 1, 2002; 62(13): 3636 - 3640.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
A. W. Hsing, A. P. Chokkalingam, Y.-T. Gao, G. Wu, X. Wang, J. Deng, J. Cheng, I. A. Sesterhenn, F. K. Mostofi, T. Chiang, et al.
Polymorphic CAG/CAA Repeat Length in the AIB1/SRC-3 Gene and Prostate Cancer Risk: A Population-based Case-Control Study
Cancer Epidemiol. Biomarkers Prev., April 1, 2002; 11(4): 337 - 341.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Wu, T. L. Foreman, C. W. Gregory, M. A. McJilton, G. G. Wescott, O. H. Ford, R. F. Alvey, J. L. Mohler, and D. M. Terrian
Protein Kinase C{epsilon} Has the Potential to Advance the Recurrence of Human Prostate Cancer
Cancer Res., April 1, 2002; 62(8): 2423 - 2429.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
D Gancberg, A Di Leo, G Rouas, T Jarvinen, A Verhest, J Isola, M J Piccart, and D Larsimont
Reliability of the tissue microarray based FISH for evaluation of the HER-2 oncogene in breast carcinoma
J. Clin. Pathol., April 1, 2002; 55(4): 315 - 317.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
A. Nyska, A. Dayan, and R. R. Maronpot
New Tools in Therapeutic Research--Prostatic Cancer and Models
Toxicol Pathol, February 1, 2002; 30(2): 283 - 287.
[PDF]

Home page
 J. Clin. Pathol.Home page
J D Oxley, M H Winkler, D A Gillatt, and D S Peat
Her-2/neu oncogene amplification in clinically localised prostate cancer
J. Clin. Pathol., February 1, 2002; 55(2): 118 - 120.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
R.S.D. Brown, J. Edwards, J.W. Bartlett, C. Jones, and A. Dogan
Routine Acid Decalcification of Bone Marrow Samples Can Preserve DNA for FISH and CGH Studies in Metastatic Prostate Cancer
J. Histochem. Cytochem., January 1, 2002; 50(1): 113 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. J. Savinainen, O. R. Saramaki, M. J. Linja, O. Bratt, T. L. J. Tammela, J. J. Isola, and T. Visakorpi
Expression and Gene Copy Number Analysis of ERBB2 Oncogene in Prostate Cancer
Am. J. Pathol., January 1, 2002; 160(1): 339 - 345.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. E. Grossmann, H. Huang, and D. J. Tindall
Androgen Receptor Signaling in Androgen-Refractory Prostate Cancer
J Natl Cancer Inst, November 21, 2001; 93(22): 1687 - 1697.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Schoenberg Fejzo and D. J. Slamon
Frozen Tumor Tissue Microarray Technology for Analysis of Tumor RNA, DNA, and Proteins
Am. J. Pathol., November 1, 2001; 159(5): 1645 - 1650.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Manley, N. R. Mucci, A. M. De Marzo, and M. A. Rubin
Relational Database Structure to Manage High-Density Tissue Microarray Data and Images for Pathology Studies Focusing on Clinical Outcome : The Prostate Specialized Program of Research Excellence Model
Am. J. Pathol., September 1, 2001; 159(3): 837 - 843.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
R. Simon, A. Nocito, T. Hubscher, C. Bucher, J. Torhorst, P. Schraml, L. Bubendorf, M. M. Mihatsch, H. Moch, K. Wilber, et al.
Patterns of HER-2/neu Amplification and Overexpression in Primary and Metastatic Breast Cancer
J Natl Cancer Inst, August 1, 2001; 93(15): 1141 - 1146.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
C-C Chiou, C-C Chan, D-L Sheu, K-T Chen, Y-S Li, and E-C Chan
Helicobacter pylori infection induced alteration of gene expression in human gastric cells
Gut, May 1, 2001; 48(5): 598 - 604.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. J. Linja, K. J. Savinainen, O. R. Saramäki, T. L. J. Tammela, R. L. Vessella, and T. Visakorpi
Amplification and Overexpression of Androgen Receptor Gene in Hormone-Refractory Prostate Cancer
Cancer Res., May 1, 2001; 61(9): 3550 - 3555.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
M. KURELLA, L.-L. HSIAO, T. YOSHIDA, J. D. RANDALL, G. CHOW, S. S. SARANG, R. V. JENSEN, and S. R. GULLANS
DNA Microarray Analysis of Complex Biologic Processes
J. Am. Soc. Nephrol., May 1, 2001; 12(5): 1072 - 1078.
[Abstract] [Full Text]

Home page
 Clin. Cancer Res.Home page
G. Buchanan, N. M. Greenberg, H. I. Scher, J. M. Harris, V. R. Marshall, and W. D. Tilley
Collocation of Androgen Receptor Gene Mutations in Prostate Cancer
Clin. Cancer Res., May 1, 2001; 7(5): 1273 - 1281.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
R. Shah, N. R. Mucci, A. Amin, J. A. Macoska, and M. A. Rubin
Postatrophic Hyperplasia of the Prostate Gland : Neoplastic Precursor or Innocent Bystander?
Am. J. Pathol., May 1, 2001; 158(5): 1767 - 1773.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
O.-P. Kallioniemi, U. Wagner, J. Kononen, and G. Sauter
Tissue microarray technology for high-throughput molecular profiling of cancer
Hum. Mol. Genet., April 1, 2001; 10(7): 657 - 662.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Hoos, M. J. Urist, A. Stojadinovic, S. Mastorides, M. E. Dudas, D. H. Y. Leung, D. Kuo, M. F. Brennan, J. J. Lewis, and C. Cordon-Cardo
Validation of Tissue Microarrays for Immunohistochemical Profiling of Cancer Specimens Using the Example of Human Fibroblastic Tumors
Am. J. Pathol., April 1, 2001; 158(4): 1245 - 1251.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. C. Alers, P.-J. Krijtenburg, A. N. Vis, R. F. Hoedemaeker, M. F. Wildhagen, W. C. J. Hop, T. H. van der Kwast, F. H. Schroder, H. J. Tanke, and H. van Dekken
Molecular Cytogenetic Analysis of Prostatic Adenocarcinomas from Screening Studies : Early Cancers May Contain Aggressive Genetic Features
Am. J. Pathol., February 1, 2001; 158(2): 399 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Specht, T. Richter, U. Muller, A. Walch, M. Werner, and H. Hofler
Quantitative Gene Expression Analysis in Microdissected Archival Formalin-Fixed and Paraffin-Embedded Tumor Tissue
Am. J. Pathol., February 1, 2001; 158(2): 419 - 429.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. M. Henshall, D. I. Quinn, C. S. Lee, D. R. Head, D. Golovsky, P. C. Brenner, W. Delprado, P. D. Stricker, J. J. Grygiel, and R. L. Sutherland
Altered Expression of Androgen Receptor in the Malignant Epithelium and Adjacent Stroma Is Associated with Early Relapse in Prostate Cancer
Cancer Res., January 1, 2001; 61(2): 423 - 427.
[Abstract] [Full Text]

Home page
 JNCI J Natl Cancer InstHome page
H. I. Scher
HER2 in Prostate Cancer--a Viable Target or Innocent Bystander?
J Natl Cancer Inst, December 6, 2000; 92(23): 1866 - 1868.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S. Signoretti, R. Montironi, J. Manola, A. Altimari, C. Tam, G. Bubley, S. Balk, G. Thomas, I. Kaplan, L. Hlatky, et al.
Her-2-neu Expression and Progression Toward Androgen Independence in Human Prostate Cancer
J Natl Cancer Inst, December 6, 2000; 92(23): 1918 - 1925.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. Abate-Shen and M. M. Shen
Molecular genetics of prostate cancer
Genes & Dev., October 1, 2000; 14(19): 2410 - 2434.
[Full Text]

Home page
 Am. J. Pathol.Home page
K. Oode, T. Furuya, K. Harada, S. Kawauchi, K. Yamamoto, T. Hirano, and K. Sasaki
The Development of a Cell Array and Its Combination with Laser-Scanning Cytometry Allows a High-Throughput Analysis of Nuclear DNA Content
Am. J. Pathol., September 1, 2000; 157(3): 723 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Richter, U. Wagner, J. Kononen, A. Fijan, J. Bruderer, U. Schmid, D. Ackermann, R. Maurer, G. Alund, H. Knonagel, et al.
High-Throughput Tissue Microarray Analysis of Cyclin E Gene Amplificati