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[Cancer Research 59, 811-815, February 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 811-815, February 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Stable Inhibition of Nuclear Factor {kappa}B in Cancer Cells Does Not Increase Sensitivity to Cytotoxic Drugs1

Mohamed Bentires-Alj, Anne-Cécile Hellin, Maya Ameyar, Salem Chouaib, Marie-Paule Merville and Vincent Bours2

Laboratory of Medical Chemistry/Medical Oncology, University of Liège, 4000 Liège, Belgium [M. B-A., A-C. H., M-P. M., V. B.]; and Institut National de la Santé et de la Recherche Médicale Unité 487, Institut Gustave-Roussy, 94805 Villejuif, France [M. A., S. C.]

Several reports indicated that nuclear factor {kappa}B (NF-{kappa}B) activation by cytokines, cytotoxic drugs, or ionizing radiation protects cells against apoptosis. Therefore, we investigated the consequence of NF-{kappa}B inhibition on the efficiency of antineoplastic agents. HPB, HCT116, MCF7, and OVCAR-3 cells stably expressing a dominant negative I{kappa}B{alpha} inhibitor showed a decreased NF-{kappa}B activation following treatment with tumor necrosis factor {alpha} and various chemotherapeutic agents. However, there was no difference in survival between parental cells and cells expressing mutated I{kappa}B{alpha}. These studies suggest that, at least in these cell lines, stable NF-{kappa}B inhibition did not modify the response to cytotoxic drugs.




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Copyright © 1999 by the American Association for Cancer Research.