Cancer Research Annual Meeting 2010 Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 811-815, February 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bentires-Alj, M.
Right arrow Articles by Bours, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bentires-Alj, M.
Right arrow Articles by Bours, V.
[Cancer Research 59, 811-815, February 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Stable Inhibition of Nuclear Factor {kappa}B in Cancer Cells Does Not Increase Sensitivity to Cytotoxic Drugs1

Mohamed Bentires-Alj, Anne-Cécile Hellin, Maya Ameyar, Salem Chouaib, Marie-Paule Merville and Vincent Bours2

Laboratory of Medical Chemistry/Medical Oncology, University of Liège, 4000 Liège, Belgium [M. B-A., A-C. H., M-P. M., V. B.]; and Institut National de la Santé et de la Recherche Médicale Unité 487, Institut Gustave-Roussy, 94805 Villejuif, France [M. A., S. C.]

Several reports indicated that nuclear factor {kappa}B (NF-{kappa}B) activation by cytokines, cytotoxic drugs, or ionizing radiation protects cells against apoptosis. Therefore, we investigated the consequence of NF-{kappa}B inhibition on the efficiency of antineoplastic agents. HPB, HCT116, MCF7, and OVCAR-3 cells stably expressing a dominant negative I{kappa}B{alpha} inhibitor showed a decreased NF-{kappa}B activation following treatment with tumor necrosis factor {alpha} and various chemotherapeutic agents. However, there was no difference in survival between parental cells and cells expressing mutated I{kappa}B{alpha}. These studies suggest that, at least in these cell lines, stable NF-{kappa}B inhibition did not modify the response to cytotoxic drugs.




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
G. Sethi, B. Sung, and B. B. Aggarwal
Nuclear Factor-{kappa}B Activation: From Bench to Bedside
Experimental Biology and Medicine, January 1, 2008; 233(1): 21 - 31.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
P. Yang, B. S. McKay, J. B. Allen, and G. J. Jaffe
Effect of NF-{kappa}B Inhibition on TNF-{alpha}-Induced Apoptosis in Human RPE Cells
Invest. Ophthalmol. Vis. Sci., July 1, 2004; 45(7): 2438 - 2446.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Shukla and S. Gupta
Suppression of Constitutive and Tumor Necrosis Factor {alpha}-Induced Nuclear Factor (NF)-{kappa}B Activation and Induction of Apoptosis by Apigenin in Human Prostate Carcinoma PC-3 Cells: Correlation with Down-Regulation of NF-{kappa}B-Responsive Genes
Clin. Cancer Res., May 1, 2004; 10(9): 3169 - 3178.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Frederich, M. Bentires-Alj, M. Tits, L. Angenot, R. Greimers, J. Gielen, V. Bours, and M.-P. Merville
Isostrychnopentamine, an Indolomonoterpenic Alkaloid from Strychnos usambarensis, Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells
J. Pharmacol. Exp. Ther., March 1, 2003; 304(3): 1103 - 1110.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
Y. Xu and M. A. Villalona-Calero
Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity
Ann. Onc., December 1, 2002; 13(12): 1841 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Baron, A. G. Turhan, J. Giron-Michel, B. Azzarone, M. Bentires-Alj, V. Bours, J. H. Bourhis, S. Chouaib, and A. Caignard
Leukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression
Blood, March 15, 2002; 99(6): 2107 - 2113.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Chen, B. Shen, L. Xia, A. Khaletzkiy, D. Chu, J. Y. C. Wong, and J.-J. Li
Activation of Nuclear Factor {kappa}B in Radioresistance of TP53-inactive Human Keratinocytes
Cancer Res., February 1, 2002; 62(4): 1213 - 1221.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
L. Benimetskaya, P. Miller, S. Benimetsky, A. Maciaszek, P. Guga, S. L. Beaucage, A. Wilk, A. Grajkowski, A. L. Halperin, and C. A. Stein
Inhibition of Potentially Anti-Apoptotic Proteins by Antisense Protein Kinase C-alpha (Isis 3521) and Antisense bcl-2 (G3139) Phosphorothioate Oligodeoxynucleotides: Relationship to the Decreased Viability of T24 Bladder and PC3 Prostate Cancer Cells
Mol. Pharmacol., December 1, 2001; 60(6): 1296 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Laurent and J.-P. Jaffrezou
Signaling pathways activated by daunorubicin
Blood, August 15, 2001; 98(4): 913 - 924.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Maestre, T. R. Tritton, G. Laurent, and J.-P. Jaffrézou
Cell Surface-directed Interaction of Anthracyclines Leads to Cytotoxicity and Nuclear Factor {{kappa}}B Activation but not Apoptosis Signaling
Cancer Res., March 1, 2001; 61(6): 2558 - 2561.
[Abstract] [Full Text]

Home page
 J. Pharmacol. Exp. Ther.Home page
A.-C. Hellin, M. Bentires-Alj, M. Verlaet, V. Benoit, J. Gielen, V. Bours, and M.-P. Merville
Roles of Nuclear Factor-kappa B, p53, and p21/WAF1 in Daunomycin-Induced Cell Cycle Arrest and Apoptosis
J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 870 - 878.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
V. B. Andela, E. M. Schwarz, J. E. Puzas, R. J. O’Keefe, and R. N. Rosier
Tumor Metastasis and the Reciprocal Regulation of Prometastatic and Antimetastatic Factors by Nuclear Factor {{kappa}}B
Cancer Res., December 1, 2000; 60(23): 6557 - 6562.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
S. Huang, J. B. Robinson, A. DeGuzman, C. D. Bucana, and I. J. Fidler
Blockade of Nuclear Factor-{{kappa}}B Signaling Inhibits Angiogenesis and Tumorigenicity of Human Ovarian Cancer Cells by Suppressing Expression of Vascular Endothelial Growth Factor and Interleukin 8
Cancer Res., October 1, 2000; 60(19): 5334 - 5339.
[Abstract] [Full Text]

Home page
 BloodHome page
G. Fang, C. N. Kim, C. L. Perkins, N. Ramadevi, E. Winton, S. Wittmann, and K. N. Bhalla
CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs
Blood, September 15, 2000; 96(6): 2246 - 2253.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. C. Cusack Jr., R. Liu, and A. S. Baldwin Jr.
Inducible Chemoresistance to 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) in Colorectal Cancer Cells and a Xenograft Model Is Overcome by Inhibition of Nuclear Factor-{{kappa}}B Activation
Cancer Res., May 1, 2000; 60(9): 2323 - 2330.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
Y. Ogiso, A. Tomida, S. Lei, S. Oura, and T. Tsuruo
Proteasome Inhibition Circumvents Solid Tumor Resistance to Topoisomerase II-directed Drugs
Cancer Res., May 1, 2000; 60(9): 2429 - 2434.
[Abstract] [Full Text]

Home page
 JNCI J Natl Cancer InstHome page
F. Pajonk, K. Pajonk, and W. H. McBride
Inhibition of NF-{kappa}B, Clonogenicity, and Radiosensitivity of Human Cancer Cells
J Natl Cancer Inst, November 17, 1999; 91(22): 1956 - 1960.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Tabata, R. Tabata, D. R. Grabowski, R. M. Bukowski, M. K. Ganapathi, and R. Ganapathi
Roles of NF-kappa B and 26 S Proteasome in Apoptotic Cell Death Induced by Topoisomerase I and II Poisons in Human Nonsmall Cell Lung Carcinoma
J. Biol. Chem., March 9, 2001; 276(11): 8029 - 8036.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.