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[Cancer Research 59, 816-822, February 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 816-822, February 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

hMSH5

A Human MutS Homologue That Forms a Novel Heterodimer with hMSH4 and Is Expressed during Spermatogenesis1

Tina Bocker, Alan Barusevicius, Tim Snowden, Debora Rasio, Shawn Guerrette, David Robbins, Carl Schmidt, John Burczak, Carlo M. Croce, Terry Copeland, Albert J. Kovatich and Richard Fishel2

Departments of Microbiology and Immunology [T. B., T. S., D. R., S. G., C. M. C., R. F.] and Pathology and Cell Biology [A. B., A. J. K.], Kimmel Cancer Institute, Thomas Jefferson University and Medical College, Philadelphia, Pennsylvania 19107; SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 [D. R., C. S., J. B.]; and ABL-Basic Research Program, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 [T. C.].

MutS homologues have been identified in nearly all organisms examined to date. They play essential roles in maintaining mitotic genetic fidelity and meiotic segregation fidelity. MutS homologues appear to function as a molecular switch that signals genomic manipulation events. Here we describe the identification of the human homologue of the Saccharomyces cerevisiae MSH5, which is known to participate in meiotic segregation fidelity and crossing-over. The human MSH5 (hMSH5) was localized to chromosome 6p22-21 and appears to play a role in meiosis because expression is induced during spermatogenesis between the late primary spermatocytes and the elongated spermatid phase. hMSH5 interacts specifically with hMSH4, confirming the generality of functional heterodimeric interactions in the eukaryotic MutS homologue, which also includes hMSH2-hMSH3 and hMSH2-hMSH6.




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Copyright © 1999 by the American Association for Cancer Research.