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[Cancer Research 59, 991-994, March 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 991-994, March 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Cyclooxygenase-2 Expression Is Up-Regulated in Squamous Cell Carcinoma of the Head and Neck1

Georgette Chan, Jay O. Boyle, Eun K. Yang, Fan Zhang, Peter G. Sacks, Jatin P. Shah, David Edelstein, Robert A. Soslow, Alane T. Koki, Bryan M. Woerner, Jaime L. Masferrer and Andrew J. Dannenberg2

Departments of Medicine [G. C., E. K. Y., A. J. D.], Thoracic Surgery [F. Z.], and Pathology [R. A. S.], New York Presbyterian Hospital and Weill Medical College of Cornell University, Strang Cancer Prevention Center [F. Z., A. J. D.], Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center [J. O. B., P. G. S., J. P. S.], and Manhattan Eye, Ear, and Throat Hospital [D. E.], New York, NY 10021, and Searle Discovery Research, Monsanto Company, St. Louis, Missouri 63017 [A. T. K., B. M. W., J. L. M.]

The purpose of this study was to determine whether cyclooxygenase-2 (COX-2) was overexpressed in squamous cell carcinoma of the head and neck (HNSCC). Quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry were used to assess the expression of COX-2 in head and neck tissue. Mean levels of COX-2 mRNA were increased by nearly 150-fold in HNSCC (n = 24) compared with normal oral mucosa from healthy volunteers (n = 17). Additionally, there was about a 50-fold increase in amounts of COX-2 mRNA in normal-appearing epithelium adjacent to HNSCC (n = 10) compared with normal oral mucosa from healthy volunteers. Immunoblotting demonstrated that COX-2 protein was present in six of six cases of HNSCC but was undetectable in normal oral mucosa from healthy subjects. Immunohistochemical analysis showed that COX-2 was expressed in both HNSCC and adjacent normal-appearing epithelium. Taken together, these results suggest that COX-2 may be a target for the prevention or treatment of HNSCC.




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D. Golijanin, J.-Y. Tan, A. Kazior, E. G. Cohen, P. Russo, G. Dalbagni, K. J. Auborn, K. Subbaramaiah, and A. J. Dannenberg
Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Are Overexpressed in Squamous Cell Carcinoma of the Penis
Clin. Cancer Res., February 1, 2004; 10(3): 1024 - 1031.
[Abstract] [Full Text] [PDF]

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 Cancer Epidemiol. Biomarkers Prev.Home page
S. Lanza-Jacoby, S. Miller, J. Flynn, K. Gallatig, C. Daskalakis, J. L. Masferrer, B. S. Zweifel, H. Sembhi, and I. H. Russo
The Cyclooxygenase-2 Inhibitor, Celecoxib, Prevents the Development of Mammary Tumors in HER-2/neu Mice
Cancer Epidemiol. Biomarkers Prev., December 1, 2003; 12(12): 1486 - 1491.
[Abstract] [Full Text] [PDF]

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 FASEB J.Home page
M. ROMANO and J. CLARIA
Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy
FASEB J, November 1, 2003; 17(14): 1986 - 1995.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
M. S. De Lorenzo, K. Yamaguchi, K. Subbaramaiah, and A. J. Dannenberg
Bryostatin-1 Stimulates the Transcription of Cyclooxygenase-2: Evidence for an Activator Protein-1-Dependent Mechanism
Clin. Cancer Res., October 15, 2003; 9(13): 5036 - 5043.
[Abstract] [Full Text] [PDF]

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 JNCI J Natl Cancer InstHome page
H. Choy and L. Milas
Enhancing Radiotherapy With Cyclooxygenase-2 Enzyme Inhibitors: A Rational Advance?
J Natl Cancer Inst, October 1, 2003; 95(19): 1440 - 1452.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
Q.-T. Le and A. J. Giaccia
Therapeutic Exploitation of the Physiological and Molecular Genetic Alterations in Head and Neck Cancer
Clin. Cancer Res., October 1, 2003; 9(12): 4287 - 4295.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. Subbaramaiah, T. P. Marmo, D. A. Dixon, and A. J. Dannenberg
Regulation of Cyclooxgenase-2 mRNA Stability by Taxanes: EVIDENCE FOR INVOLVEMENT OF p38, MAPKAPK-2, and HuR
J. Biol. Chem., September 26, 2003; 278(39): 37637 - 37647.
[Abstract] [Full Text] [PDF]

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 Ann. Thorac. Surg.Home page
K.-T. Kuo, K.-C. Chow, Y.-C. Wu, C.-S. Lin, H.-W. Wang, W.-Y. Li, and L.-S. Wang
Clinicopathologic significance of cyclooxygenase-2 overexpression in esophageal squamous cell carcinoma
Ann. Thorac. Surg., September 1, 2003; 76(3): 909 - 914.
[Abstract] [Full Text] [PDF]

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 CROBMHome page
P. K. Ha and J. A. Califano
THE MOLECULAR BIOLOGY OF MUCOSAL FIELD CANCERIZATION OF THE HEAD AND NECK
Critical Reviews in Oral Biology & Medicine, September 1, 2003; 14(5): 363 - 369.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
E. G. Cohen, T. Almahmeed, B. Du, D. Golijanin, J. O. Boyle, R. A. Soslow, K. Subbaramaiah, and A. J. Dannenberg
Microsomal Prostaglandin E Synthase-1 Is Overexpressed in Head and Neck Squamous Cell Carcinoma
Clin. Cancer Res., August 1, 2003; 9(9): 3425 - 3430.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J.-H. Jeng, Y.-J. Wang, B.-L. Chiang, P.-H. Lee, C.-P. Chan, Y.-S. Ho, T.-M. Wang, J.-J. Lee, L.-J. Hahn, and M.-C. Chang
Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-{alpha} production of oral epithelial cells by areca nut extract and arecoline
Carcinogenesis, August 1, 2003; 24(8): 1301 - 1315.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
D. Y. Zhang, J. Wu, F. Ye, L. Xue, S. Jiang, J. Yi, W. Zhang, H. Wei, M. Sung, W. Wang, et al.
Inhibition of Cancer Cell Proliferation and Prostaglandin E2 Synthesis by Scutellaria Baicalensis
Cancer Res., July 15, 2003; 63(14): 4037 - 4043.
[Abstract] [Full Text] [PDF]

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 JCOHome page
N.K. Altorki, R.S. Keresztes, J.L. Port, D.M. Libby, R.J. Korst, D.B. Flieder, C.A. Ferrara, D.F. Yankelevitz, K. Subbaramaiah, M.W. Pasmantier, et al.
Celecoxib, a Selective Cyclo-Oxygenase-2 Inhibitor, Enhances the Response to Preoperative Paclitaxel and Carboplatin in Early-Stage Non-Small-Cell Lung Cancer
J. Clin. Oncol., July 15, 2003; 21(14): 2645 - 2650.
[Abstract] [Full Text] [PDF]

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 Journal of the American Dental AssociationHome page
F. ZHANG, S. P. ENGEBRETSON, R. S. MORTON, P. F. CAVANAUGH JR., K. SUBBARAMAIAH, and A. J. DANNENBERG
The overexpression of cyclo-oxygenase-2 in chronic periodontitis
J Am Dent Assoc, July 1, 2003; 134(7): 861 - 867.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
H. A. Minter, J. W. Eveson, S. Huntley, D. J. E. Elder, and A. Hague
The Cyclooxygenase 2-selective Inhibitor NS398 Inhibits Proliferation of Oral Carcinoma Cell Lines by Mechanisms Dependent and Independent of Reduced Prostaglandin E2 Synthesis
Clin. Cancer Res., May 1, 2003; 9(5): 1885 - 1897.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. Dohadwala, R. K. Batra, J. Luo, Y. Lin, K. Krysan, M. Pold, S. Sharma, and S. M. Dubinett
Autocrine/Paracrine Prostaglandin E2 Production by Non-small Cell Lung Cancer Cells Regulates Matrix Metalloproteinase-2 and CD44 in Cyclooxygenase-2-dependent Invasion
J. Biol. Chem., December 20, 2002; 277(52): 50828 - 50833.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
M. A. C. Sabino, J. R. Ghilardi, J. L. M. Jongen, C. P. Keyser, N. M. Luger, D. B. Mach, C. M. Peters, S. D. Rogers, M. J. Schwei, C. de Felipe, et al.
Simultaneous Reduction in Cancer Pain, Bone Destruction, and Tumor Growth by Selective Inhibition of Cyclooxygenase-2
Cancer Res., December 15, 2002; 62(24): 7343 - 7349.
[Abstract] [Full Text] [PDF]

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 Molecular Cancer TherapeuticsHome page
A. G. Banerjee, V. K. Gopalakrishnan, I. Bhattacharya, and J. K. Vishwanatha
Deregulated Cyclooxygenase-2 Expression in Oral Premalignant Tissues
Mol. Cancer Ther., December 1, 2002; 1(14): 1265 - 1271.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
B. S. Zweifel, T. W. Davis, R. L. Ornberg, and J. L. Masferrer
Direct Evidence for a Role of Cyclooxygenase 2-derived Prostaglandin E2 in Human Head and Neck Xenograft Tumors
Cancer Res., November 15, 2002; 62(22): 6706 - 6711.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
P. S. Carlton, R. Gopalakrishnan, A. Gupta, B. W. Liston, S. Habib, M. A. Morse, and G. D. Stoner
Piroxicam Is an Ineffective Inhibitor of N-Nitrosomethylbenzylamine-induced Tumorigenesis in the Rat Esophagus
Cancer Res., August 1, 2002; 62(15): 4376 - 4382.
[Abstract] [Full Text] [PDF]

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 J. Clin. Pathol.Home page
C Costa, R Soares, J S Reis-Filho, D Leitao, I Amendoeira, and F C Schmitt
Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer
J. Clin. Pathol., June 1, 2002; 55(6): 429 - 434.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. Subbaramaiah, L. Norton, W. Gerald, and A. J. Dannenberg
Cyclooxygenase-2 Is Overexpressed in HER-2/neu-positive Breast Cancer. EVIDENCE FOR INVOLVEMENT OF AP-1 AND PEA3
J. Biol. Chem., May 17, 2002; 277(21): 18649 - 18657.
[Abstract] [Full Text] [PDF]

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 Ann OncolHome page
G. Davies, L.-A. Martin, N. Sacks, and M. Dowsett
Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention
Ann. Onc., May 1, 2002; 13(5): 669 - 678.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
K. Subbaramaiah, P. A. Cole, and A. J. Dannenberg
Retinoids and Carnosol Suppress Cyclooxygenase-2 Transcription by CREB-binding Protein/p300-dependent and -independent Mechanisms
Cancer Res., May 1, 2002; 62(9): 2522 - 2530.
[Abstract] [Full Text] [PDF]

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 Integr Cancer TherHome page
J. M. Wallace
Nutritional and Botanical Modulation of the Inflammatory Cascade--Eicosanoids, Cyclooxygenases, and Lipoxygenases-- As an Adjunct in Cancer Therapy
Integr Cancer Ther, March 1, 2002; 1(1): 7 - 37.
[Abstract] [PDF]

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 Am. J. Pathol.Home page
C. Denkert, M. Kobel, S. Pest, I. Koch, S. Berger, M. Schwabe, A. Siegert, A. Reles, B. Klosterhalfen, and S. Hauptmann
Expression of Cyclooxygenase 2 Is an Independent Prognostic Factor in Human Ovarian Carcinoma
Am. J. Pathol., March 1, 2002; 160(3): 893 - 903.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
T. Niki, T. Kohno, S. Iba, Y. Moriya, Y. Takahashi, M. Saito, A. Maeshima, T. Yamada, Y. Matsuno, M. Fukayama, et al.
Frequent Co-Localization of Cox-2 and Laminin-5 {gamma}2 Chain at the Invasive Front of Early-Stage Lung Adenocarcinomas
Am. J. Pathol., March 1, 2002; 160(3): 1129 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Denda, W. Kitayama, A. Murata, H. Kishida, Y. Sasaki, O. Kusuoka, T. Tsujiuchi, M. Tsutsumi, D. Nakae, H. Takagi, et al.
Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide
Carcinogenesis, February 1, 2002; 23(2): 245 - 256.
[Abstract] [Full Text] [PDF]

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 CarcinogenesisHome page
V. de Ledinghen, H. Liu, F. Zhang, C. R. Lo, K. Subbaramaiah, A. J. Dannenberg, and M. J. Czaja
Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes
Carcinogenesis, January 1, 2002; 23(1): 73 - 79.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
Y. Cao, K. B. Dave, T. P. Doan, and S. M. Prescott
Fatty Acid CoA Ligase 4 Is Up-Regulated in Colon Adenocarcinoma
Cancer Res., December 1, 2001; 61(23): 8429 - 8434.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
K. Yoshimatsu, D. Golijanin, P. B. Paty, R. A. Soslow, P.-J. Jakobsson, R. A. DeLellis, K. Subbaramaiah, and A. J. Dannenberg
Inducible Microsomal Prostaglandin E Synthase Is Overexpressed in Colorectal Adenomas and Cancer
Clin. Cancer Res., December 1, 2001; 7(12): 3971 - 3976.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
K. Salmenkivi, C. Haglund, A. Ristimaki, J. Arola, and P. Heikkila
Increased Expression of Cyclooxygenase-2 in Malignant Pheochromocytomas
J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5615 - 5619.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
A. Onn, J. E. Tseng, and R. S. Herbst
Thalidomide, Cyclooxygenase-2, and Angiogenesis: Potential for Therapy
Clin. Cancer Res., November 1, 2001; 7(11): 3311 - 3313.
[Full Text] [PDF]

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 Clin. Cancer Res.Home page
J. Fujita, J. R. Mestre, J. B. Zeldis, K. Subbaramaiah, and A. J. Dannenberg
Thalidomide and Its Analogues Inhibit Lipopolysaccharide-mediated Induction of Cyclooxygenase-2
Clin. Cancer Res., November 1, 2001; 7(11): 3349 - 3355.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
A. H. Klimp, H. Hollema, C. Kempinga, A. G. J. van der Zee, E. G. E. de Vries, and T. Daemen
Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Human Ovarian Tumors and Tumor-associated Macrophages
Cancer Res., October 1, 2001; 61(19): 7305 - 7309.
[Abstract] [Full Text] [PDF]

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 Arch Otolaryngol Head Neck SurgHome page
E. C. Jaeckel, S. Raja, J. Tan, S. K. Das, S. K. Dey, D. A. Girod, T. T. Tsue, and T. R. Sanford
Correlation of Expression of Cyclooxygenase-2, Vascular Endothelial Growth Factor, and Peroxisome Proliferator-Activated Receptor {delta} With Head and Neck Squamous Cell Carcinoma
Arch Otolaryngol Head Neck Surg, October 1, 2001; 127(10): 1253 - 1259.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
H. Pyo, H. Choy, G. P. Amorino, J.-s. Kim, Q. Cao, S. K. Hercules, and R. N. DuBois
A Selective Cyclooxygenase-2 Inhibitor, NS-398, Enhances the Effect of Radiation in Vitro and in Vivo Preferentially on the Cells That Express Cyclooxygenase-2
Clin. Cancer Res., October 1, 2001; 7(10): 2998 - 3005.
[Abstract] [Full Text] [PDF]

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 J. Histochem. Cytochem.Home page
E. M. P. de Almeida, C. Piche, J. Sirois, and M. Dore
Expression of Cyclo-oxygenase-2 in Naturally Occurring Squamous Cell Carcinomas in Dogs
J. Histochem. Cytochem., July 1, 2001; 49(7): 867 - 876.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
T. Shono, P. J. Tofilon, J. M. Bruner, O. Owolabi, and F. F. Lang
Cyclooxygenase-2 Expression in Human Gliomas: Prognostic Significance and Molecular Correlations
Cancer Res., June 1, 2001; 61(11): 4375 - 4381.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
S. Murono, H. Inoue, T. Tanabe, I. Joab, T. Yoshizaki, M. Furukawa, and J. S. Pagano
Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells
PNAS, May 24, 2001; (2001) 121016998.
[Abstract] [Full Text] [PDF]


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