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[Cancer Research 59, 991-994, March 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 991-994, March 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Cyclooxygenase-2 Expression Is Up-Regulated in Squamous Cell Carcinoma of the Head and Neck1

Georgette Chan, Jay O. Boyle, Eun K. Yang, Fan Zhang, Peter G. Sacks, Jatin P. Shah, David Edelstein, Robert A. Soslow, Alane T. Koki, Bryan M. Woerner, Jaime L. Masferrer and Andrew J. Dannenberg2

Departments of Medicine [G. C., E. K. Y., A. J. D.], Thoracic Surgery [F. Z.], and Pathology [R. A. S.], New York Presbyterian Hospital and Weill Medical College of Cornell University, Strang Cancer Prevention Center [F. Z., A. J. D.], Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center [J. O. B., P. G. S., J. P. S.], and Manhattan Eye, Ear, and Throat Hospital [D. E.], New York, NY 10021, and Searle Discovery Research, Monsanto Company, St. Louis, Missouri 63017 [A. T. K., B. M. W., J. L. M.]

The purpose of this study was to determine whether cyclooxygenase-2 (COX-2) was overexpressed in squamous cell carcinoma of the head and neck (HNSCC). Quantitative reverse transcription-PCR, immunoblotting, and immunohistochemistry were used to assess the expression of COX-2 in head and neck tissue. Mean levels of COX-2 mRNA were increased by nearly 150-fold in HNSCC (n = 24) compared with normal oral mucosa from healthy volunteers (n = 17). Additionally, there was about a 50-fold increase in amounts of COX-2 mRNA in normal-appearing epithelium adjacent to HNSCC (n = 10) compared with normal oral mucosa from healthy volunteers. Immunoblotting demonstrated that COX-2 protein was present in six of six cases of HNSCC but was undetectable in normal oral mucosa from healthy subjects. Immunohistochemical analysis showed that COX-2 was expressed in both HNSCC and adjacent normal-appearing epithelium. Taken together, these results suggest that COX-2 may be a target for the prevention or treatment of HNSCC.




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