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[Cancer Research 59, 1175-1179, March 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 1175-1179, March 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Expression of Estrogen Receptor ß1, ß2, and ß5 Messenger RNAs in Human Breast Tissue1

Etienne Leygue2, Helmut Dotzlaw, Peter H. Watson and Leigh C. Murphy

Departments of Biochemistry and Molecular Biology [E. L., H. D., L. C. M.] and Pathology [P. H. W.], University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba R3E OW3, Canada

A triple-primer PCR assay was developed, based on the coamplification of estrogen receptor (ER)-ß1, -ß2, and -ß5 cDNAs, to investigate the relative expressions of the corresponding mRNAs in breast cancer lines and in 53 independent breast tumors. The expression of ER-ß2 and ER-ß5 mRNAs was higher than that of ER-ß1 mRNA in both cancer cell lines and breast tumors. In breast tumors, increases in the ER-ß2:ER-ß1 and ER-ß5:ER-ß1 mRNA expression ratios were observed, which positively correlated with the level of tumor inflammation and tumor grade, respectively. A trend toward an increase of these ratios was also found in tumors, as compared to the normal adjacent breast tissue available for 13 cases. Our data suggest that changes in the relative expression of ER-ß1, -ß2, and -ß5 mRNAs occur during breast tumorigenesis and tumor progression.




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Copyright © 1999 by the American Association for Cancer Research.