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[Cancer Research 59, 1188-1191, March 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 1188-1191, March 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Quantitative Analysis of Cell-free Epstein-Barr Virus DNA in Plasma of Patients with Nasopharyngeal Carcinoma1

Y. M. Dennis Lo2, Lisa Y. S. Chan, Kwok-Wai Lo, Sing-Fai Leung, Jun Zhang, Anthony T. C. Chan, Joseph C. K. Lee, N. Magnus Hjelm, Philip J. Johnson and Dolly P. Huang

Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C., J. Z., N. M. H.], Anatomical and Cellular Pathology [K-W. L., J. C. K. L., D. P. H.], and Clinical Oncology and the Sir YK Pao Cancer Center [S-F. L. A. T. C. C., P. J. J.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region

Using real-time quantitative PCR, cell-free EBV DNA was detectable in the plasma of 96% (55 of 57) of nasopharyngeal carcinoma (NPC) patients (median concentration, 21058 copies/ml) and 7% (3 of 43) of controls (median concentration, 0 copies/ml). Advanced-stage NPC patients had higher plasma EBV DNA levels than those with early-stage disease. At 1 month after completion of radiotherapy, plasma EBV DNA was undetecTable in 7 of 15 subjects (47%) but remained high in the remaining 8 subjects (53%). Clinical examination revealed that all of the former seven subjects had complete tumor regression, whereas six of the eight latter subjects exhibited evidence of disease persistence or had developed distant metastases. These results suggest that quantitative analysis of plasma EBV DNA may be a useful clinical and research tool in the screening and monitoring of NPC patients.




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 Clin. Cancer Res.Home page
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Circulating Epstein-Barr Virus DNA in Serum of Patients with Lymphoepithelioma-like Carcinoma of the Lung: A Potential Surrogate Marker for Monitoring Disease
Clin. Cancer Res., April 1, 2002; 8(4): 986 - 994.
[Abstract] [Full Text] [PDF]

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 Nucleic Acids ResHome page
I. M. Mackay, K. E. Arden, and A. Nitsche
Real-time PCR in virology
Nucleic Acids Res., March 15, 2002; 30(6): 1292 - 1305.
[Abstract] [Full Text] [PDF]

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 Cancer Epidemiol. Biomarkers Prev.Home page
S. M. Dong, S. I. Pai, S.-H. Rha, A. Hildesheim, R. J. Kurman, P. E. Schwartz, R. Mortel, L. McGowan, M. D. Greenberg, W. A. Barnes, et al.
Detection and Quantitation of Human Papillomavirus DNA in the Plasma of Patients with Cervical Carcinoma
Cancer Epidemiol. Biomarkers Prev., January 1, 2002; 11(1): 3 - 6.
[Abstract] [Full Text]

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 Clin. Cancer Res.Home page
K. I. K. Lei, L. Y. S. Chan, W.-Y. Chan, P. J. Johnson, and Y. M. D. Lo
Diagnostic and Prognostic Implications of Circulating Cell-free Epstein-Barr Virus DNA in Natural Killer/T-Cell Lymphoma
Clin. Cancer Res., January 1, 2002; 8(1): 29 - 34.
[Abstract] [Full Text] [PDF]

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 NEJMHome page
A. Forastiere, W. Koch, A. Trotti, and D. Sidransky
Head and Neck Cancer
N. Engl. J. Med., December 27, 2001; 345(26): 1890 - 1900.
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 Clin. Cancer Res.Home page
J. M. Silva, G. Dominguez, J. Silva, J. M. Garcia, A. Sanchez, O. Rodriguez, M. Provencio, P. Espana, and F. Bonilla
Detection of Epithelial Messenger RNA in the Plasma of Breast Cancer Patients Is Associated with Poor Prognosis Tumor Characteristics
Clin. Cancer Res., September 1, 2001; 7(9): 2821 - 2825.
[Abstract] [Full Text] [PDF]

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 Arch Otolaryngol Head Neck SurgHome page
W. I. Wei
Nasopharyngeal Cancer: Current Status of Management: A New York Head and Neck Society Lecture
Arch Otolaryngol Head Neck Surg, July 1, 2001; 127(7): 766 - 769.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
Y. M. D. Lo, W. Y. Chan, E. K. W. Ng, L. Y. S. Chan, P. B. S. Lai, J. S. Tam, and S. C. S. Chung
Circulating Epstein-Barr Virus DNA in the Serum of Patients with Gastric Carcinoma
Clin. Cancer Res., July 1, 2001; 7(7): 1856 - 1859.
[Abstract] [Full Text] [PDF]

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 JCOHome page
J.-C. Lin, K. Y. Chen, W.-Y. Wang, J.-S. Jan, W.-M. Liang, C.-S. Tsai, and Y.-H. Wei
Detection of Epstein-Barr Virus DNA in the Peripheral-Blood Cells of Patients With Nasopharyngeal Carcinoma: Relationship to Distant Metastasis and Survival
J. Clin. Oncol., May 15, 2001; 19(10): 2607 - 2615.
[Abstract] [Full Text] [PDF]

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 J. Clin. Microbiol.Home page
S. J. C. Stevens, I. Pronk, and J. M. Middeldorp
Toward Standardization of Epstein-Barr Virus DNA Load Monitoring: Unfractionated Whole Blood as Preferred Clinical Specimen
J. Clin. Microbiol., April 1, 2001; 39(4): 1211 - 1216.
[Abstract] [Full Text]

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 J. Clin. Microbiol.Home page
W. J. Jabs, H. Hennig, M. Kittel, K. Pethig, F. Smets, P. Bucsky, H. Kirchner, and H. J. Wagner
Normalized Quantification by Real-Time PCR of Epstein-Barr Virus Load in Patients at Risk for Posttransplant Lymphoproliferative Disorders
J. Clin. Microbiol., February 1, 2001; 39(2): 564 - 569.
[Abstract] [Full Text]

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 J. Mol. Diagn.Home page
M. L. Gulley
Molecular Diagnosis of Epstein-Barr Virus-Related Diseases
J. Mol. Diagn., February 1, 2001; 3(1): 1 - 10.
[Abstract] [Full Text]

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 BloodHome page
J. Yang, Q. Tao, I. W. Flinn, P. G. Murray, L. E. Post, H. Ma, S. Piantadosi, M. A. Caligiuri, and R. F. Ambinder
Characterization of Epstein-Barr virus-infected B cells in patients with posttransplantation lymphoproliferative disease: disappearance after rituximab therapy does not predict clinical response
Blood, December 15, 2000; 96(13): 4055 - 4063.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
Y. M. D. Lo, A. T. C. Chan, L. Y. S. Chan, S.-F. Leung, C.-W. Lam, D. P. Huang, and P. J. Johnson
Molecular Prognostication of Nasopharyngeal Carcinoma by Quantitative Analysis of Circulating Epstein-Barr Virus DNA
Cancer Res., December 1, 2000; 60(24): 6878 - 6881.
[Abstract] [Full Text]

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 Clin. Cancer Res.Home page
R. B. Capone, S. I. Pai, W. M. Koch, M. L. Gillison, H. N. Danish, W. H. Westra, R. Daniel, K. V. Shah, and D. Sidransky
Detection and Quantitation of Human Papillomavirus (HPV) DNA in the Sera of Patients with HPV-associated Head and Neck Squamous Cell Carcinoma
Clin. Cancer Res., November 1, 2000; 6(11): 4171 - 4175.
[Abstract] [Full Text] [PDF]

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 J. Gen. Virol.Home page
P. Feng, E. C. Ren, D. Liu, S. H. Chan, and H. Hu
Expression of Epstein-Barr virus lytic gene BRLF1 in nasopharyngeal carcinoma: potential use in diagnosis
J. Gen. Virol., October 1, 2000; 81(10): 2417 - 2423.
[Abstract] [Full Text]

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 Clin. Chem.Home page
Y.M. D. Lo
Molecular Testing of Urine: Catching DNA on the Way Out
Clin. Chem., August 1, 2000; 46(8): 1039 - 1040.
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 Clin. Chem.Home page
I. Botezatu, O.'g. Serdyuk, G. Potapova, V. Shelepov, R. Alechina, Y. Molyaka, V. Anan'ev, I. Bazin, A. Garin, M. Narimanov, et al.
Genetic Analysis of DNA Excreted in Urine: A New Approach for Detecting Specific Genomic DNA Sequences from Cells Dying in an Organism
Clin. Chem., August 1, 2000; 46(8): 1078 - 1084.
[Abstract] [Full Text] [PDF]

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 J. Clin. Microbiol.Home page
M. Clementi
Quantitative Molecular Analysis of Virus Expression and Replication
J. Clin. Microbiol., June 1, 2000; 38(6): 2030 - 2036.
[Full Text]

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 Cancer Res.Home page
Y. M. D. Lo, S.-F. Leung, L. Y. S. Chan, A. T. C. Chan, K.-W. Lo, P. J. Johnson, and D. P. Huang
Kinetics of Plasma Epstein-Barr Virus DNA during Radiation Therapy for Nasopharyngeal Carcinoma
Cancer Res., May 1, 2000; 60(9): 2351 - 2355.
[Abstract] [Full Text]

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 Clin. Cancer Res.Home page
K. Shotelersuk, C. Khorprasert, S. Sakdikul, W. Pornthanakasem, N. Voravud, and A. Mutirangura
Epstein-Barr Virus DNA in Serum/Plasma as a Tumor Marker for Nasopharyngeal Cancer
Clin. Cancer Res., March 1, 2000; 6(3): 1046 - 1051.
[Abstract] [Full Text]

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 Cancer Res.Home page
Y. M. Dennis Lo, L. Y. S. Chan, A. T. C. Chan, S.-F. Leung, K.-W. Lo, J. Zhang, J. C. K. Lee, N. M. Hjelm, P. J. Johnson, and D. P. Huang
Quantitative and Temporal Correlation between Circulating Cell-Free Epstein-Barr Virus DNA and Tumor Recurrence in Nasopharyngeal Carcinoma
Cancer Res., November 1, 1999; 59(21): 5452 - 5455.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
Y. M. D. Lo, I. H. N. Wong, J. Zhang, M. S. C. Tein, M. H. L. Ng, and N. M. Hjelm
Quantitative Analysis of Aberrant p16 Methylation Using Real-Time Quantitative Methylation-specific Polymerase Chain Reaction
Cancer Res., August 1, 1999; 59(16): 3899 - 3903.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
K.-W. Lo, Y.M. D. Lo, S.-F. Leung, Y.-S. Tsang, L. Y.S. Chan, P. J. Johnson, N. M. Hjelm, J. C.K. Lee, and D. P. Huang
Analysis of Cell-free Epstein-Barr Virus-associated RNA in the Plasma of Patients with Nasopharyngeal Carcinoma
Clin. Chem., August 1, 1999; 45(8): 1292 - 1294.
[Full Text] [PDF]


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