Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 1188-1191, March 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lo, Y. M. D.
Right arrow Articles by Huang, D. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lo, Y. M. D.
Right arrow Articles by Huang, D. P.
[Cancer Research 59, 1188-1191, March 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Quantitative Analysis of Cell-free Epstein-Barr Virus DNA in Plasma of Patients with Nasopharyngeal Carcinoma1

Y. M. Dennis Lo2, Lisa Y. S. Chan, Kwok-Wai Lo, Sing-Fai Leung, Jun Zhang, Anthony T. C. Chan, Joseph C. K. Lee, N. Magnus Hjelm, Philip J. Johnson and Dolly P. Huang

Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C., J. Z., N. M. H.], Anatomical and Cellular Pathology [K-W. L., J. C. K. L., D. P. H.], and Clinical Oncology and the Sir YK Pao Cancer Center [S-F. L. A. T. C. C., P. J. J.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region

Using real-time quantitative PCR, cell-free EBV DNA was detectable in the plasma of 96% (55 of 57) of nasopharyngeal carcinoma (NPC) patients (median concentration, 21058 copies/ml) and 7% (3 of 43) of controls (median concentration, 0 copies/ml). Advanced-stage NPC patients had higher plasma EBV DNA levels than those with early-stage disease. At 1 month after completion of radiotherapy, plasma EBV DNA was undetecTable in 7 of 15 subjects (47%) but remained high in the remaining 8 subjects (53%). Clinical examination revealed that all of the former seven subjects had complete tumor regression, whereas six of the eight latter subjects exhibited evidence of disease persistence or had developed distant metastases. These results suggest that quantitative analysis of plasma EBV DNA may be a useful clinical and research tool in the screening and monitoring of NPC patients.




This article has been cited by other articles:


Home page
 RNAHome page
J. M. Garcia, V. Garcia, C. Pena, G. Dominguez, J. Silva, R. Diaz, P. Espinosa, M. J. Citores, M. Collado, and F. Bonilla
Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched
RNA, July 1, 2008; 14(7): 1424 - 1432.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
M. L. Gulley and W. Tang
Laboratory Assays for Epstein-Barr Virus-Related Disease
J. Mol. Diagn., July 1, 2008; 10(4): 279 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K.C. A. Chan, S.-F. Leung, S.-W. Yeung, A. T.C. Chan, and Y.M. D. Lo
Persistent Aberrations in Circulating DNA Integrity after Radiotherapy Are Associated with Poor Prognosis in Nasopharyngeal Carcinoma Patients
Clin. Cancer Res., July 1, 2008; 14(13): 4141 - 4145.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. C. Chia, A. Leung, T. Krushel, N. M. Alajez, K. W. Lo, P. Busson, H. J. Klamut, C. Bastianutto, and F.-F. Liu
Nuclear Factor-Y and Epstein Barr Virus in Nasopharyngeal Cancer
Clin. Cancer Res., February 15, 2008; 14(4): 984 - 994.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. M. Garcia, C. Pena, V. Garcia, G. Dominguez, C. Munoz, J. Silva, I. Millan, R. Diaz, Y. Lorenzo, R. Rodriguez, et al.
Prognostic Value of LISCH7 mRNA in Plasma and Tumor of Colon Cancer Patients
Clin. Cancer Res., November 1, 2007; 13(21): 6351 - 6358.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
C. K. Wong, B. C. K. Wong, K. C. A. Chan, G. M. Joynt, F. Y. H. Y. Yap, C. W. K. Lam, N. Lee, S. S. Lee, C. S. Cockram, J. J. Y. Sung, et al.
Cytokine Profile in Fatal Human Immunodeficiency Virus Tuberculosis Epstein-Barr Virus Associated Hemophagocytic Syndrome
Arch Intern Med, September 24, 2007; 167(17): 1901 - 1903.
[Full Text] [PDF]

Home page
 JCOHome page
O. Riesterer, L. Milas, and K. K. Ang
Use of Molecular Biomarkers for Predicting the Response to Radiotherapy With or Without Chemotherapy
J. Clin. Oncol., September 10, 2007; 25(26): 4075 - 4083.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
H. Hakim, C. Gibson, J. Pan, K. Srivastava, Z. Gu, M. J. Bankowski, and R. T. Hayden
Comparison of Various Blood Compartments and Reporting Units for the Detection and Quantification of Epstein-Barr Virus in Peripheral Blood
J. Clin. Microbiol., July 1, 2007; 45(7): 2151 - 2155.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
J J-Y Lu, D-Y Chen, C-W Hsieh, J-L Lan, F-J Lin, and S-H Lin
Association of Epstein-Barr virus infection with systemic lupus erythematosus in Taiwan
Lupus, March 1, 2007; 16(3): 168 - 175.
[Abstract] [PDF]

Home page
 J. Virol.Home page
H.-H. Chua, H.-H. Lee, S.-S. Chang, C.-C. Lu, T.-H. Yeh, T.-Y. Hsu, T.-H. Cheng, J.-T. Cheng, M.-R. Chen, and C.-H. Tsai
Role of the TSG101 Gene in Epstein-Barr Virus Late Gene Transcription
J. Virol., March 1, 2007; 81(5): 2459 - 2471.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
W. C.S. Cho, T. T.C. Yip, R. K.C. Ngan, T.-T. Yip, V. N. Podust, C. Yip, H. H.Y. Yiu, V. Yip, W.-W. Cheng, V. W.S. Ma, et al.
ProteinChip Array Profiling for Identification of Disease- and Chemotherapy-Associated Biomarkers of Nasopharyngeal Carcinoma
Clin. Chem., February 1, 2007; 53(2): 241 - 250.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S.-f. Leung, B. Zee, B. B. Ma, E. P. Hui, F. Mo, M. Lai, K.C. A. Chan, L. Y.S. Chan, W.-h. Kwan, Y.M. D. Lo, et al.
Plasma Epstein-Barr Viral Deoxyribonucleic Acid Quantitation Complements Tumor-Node-Metastasis Staging Prognostication in Nasopharyngeal Carcinoma
J. Clin. Oncol., December 1, 2006; 24(34): 5414 - 5418.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
E. T. Chang and H.-O. Adami
The enigmatic epidemiology of nasopharyngeal carcinoma.
Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1765 - 1777.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. C.K. Wong, K.C. A. Chan, A. T.C. Chan, S.-F. Leung, L. Y.S. Chan, K. C.K. Chow, and Y.M. D. Lo
Reduced Plasma RNA Integrity in Nasopharyngeal Carcinoma Patients
Clin. Cancer Res., April 15, 2006; 12(8): 2512 - 2516.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
V. Garcia, J. M. Garcia, C. Pena, J. Silva, G. Dominguez, A. Hurtado, I. Alonso, R. Rodriguez, M. Provencio, and F. Bonilla
Thymidylate synthase messenger RNA expression in plasma from patients with colon cancer: prognostic potential.
Clin. Cancer Res., April 1, 2006; 12(7): 2095 - 2100.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
J. Li, L. Harris, H. Mamon, M. H. Kulke, W.-H. Liu, P. Zhu, and G. Mike Makrigiorgos
Whole Genome Amplification of Plasma-Circulating DNA Enables Expanded Screening for Allelic Imbalance in Plasma
J. Mol. Diagn., February 1, 2006; 8(1): 22 - 30.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. K. Gandhi, E. Lambley, J. Burrows, U. Dua, S. Elliott, P. J. Shaw, H. M. Prince, M. Wolf, K. Clarke, C. Underhill, et al.
Plasma Epstein-Barr Virus (EBV) DNA Is a Biomarker for EBV-Positive Hodgkin's Lymphoma
Clin. Cancer Res., January 15, 2006; 12(2): 460 - 464.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
M. J. Espy, J. R. Uhl, L. M. Sloan, S. P. Buckwalter, M. F. Jones, E. A. Vetter, J. D. C. Yao, N. L. Wengenack, J. E. Rosenblatt, F. R. Cockerill III, et al.
Real-Time PCR in Clinical Microbiology: Applications for Routine Laboratory Testing
Clin. Microbiol. Rev., January 1, 2006; 19(1): 165 - 256.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K.C. A. Chan, A. T.C. Chan, S.-F. Leung, J. C.S. Pang, A. Y.M. Wang, J. H.M. Tong, K.-F. To, L. Y.S. Chan, L. L.S. Tam, N. Y.F. Chung, et al.
Investigation into the Origin and Tumoral Mass Correlation of Plasma Epstein-Barr Virus DNA in Nasopharyngeal Carcinoma
Clin. Chem., November 1, 2005; 51(11): 2192 - 2195.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Q.-T. Le, C. D. Jones, T.-K. Yau, H. A. Shirazi, P. H. Wong, E. N. Thomas, B. K. Patterson, A. W.M. Lee, and J. L. Zehnder
A Comparison Study of Different PCR Assays in Measuring Circulating Plasma Epstein-Barr Virus DNA Levels in Patients with Nasopharyngeal Carcinoma
Clin. Cancer Res., August 15, 2005; 11(16): 5700 - 5707.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Yang, K. Yang, A. Khafagi, Y. Tang, T. E. Carey, A. W. Opipari, R. Lieberman, P. A. Oeth, W. Lancaster, H. P. Klinger, et al.
Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies
PNAS, May 24, 2005; 102(21): 7683 - 7688.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. R. Gingeras, R. Higuchi, L. J. Kricka, Y.M. D. Lo, and C. T. Wittwer
Fifty Years of Molecular (DNA/RNA) Diagnostics
Clin. Chem., March 1, 2005; 51(3): 661 - 671.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
L. C.W. Lit, K.C. A. Chan, S.-F. Leung, K. I.K. Lei, L. Y.S. Chan, K. C.K. Chow, A. T.C. Chan, and Y.M. D. Lo
Distribution of Cell-Free and Cell-Associated Epstein-Barr Virus (EBV) DNA in the Blood of Patients with Nasopharyngeal Carcinoma and EBV-Associated Lymphoma
Clin. Chem., October 1, 2004; 50(10): 1842 - 1845.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Holdenrieder, P. Stieber, J. von Pawel, H. Raith, D. Nagel, K. Feldmann, and D. Seidel
Circulating Nucleosomes Predict the Response to Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer
Clin. Cancer Res., September 15, 2004; 10(18): 5981 - 5987.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. T.C. Chan, B. B.Y. Ma, Y.M. D. Lo, S.F. Leung, W.H. Kwan, E. P. Hui, T. S.K. Mok, M. Kam, L. S. Chan, S. K.W. Chiu, et al.
Phase II Study of Neoadjuvant Carboplatin and Paclitaxel Followed by Radiotherapy and Concurrent Cisplatin in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma: Therapeutic Monitoring With Plasma Epstein-Barr Virus DNA
J. Clin. Oncol., August 1, 2004; 22(15): 3053 - 3060.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
V. Sriuranpong, A. Mutirangura, J. W. Gillespie, V. Patel, P. Amornphimoltham, A. A. Molinolo, V. Kerekhanjanarong, S. Supanakorn, P. Supiyaphun, S. Rangdaeng, et al.
Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays
Clin. Cancer Res., August 1, 2004; 10(15): 4944 - 4958.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Ding, R. W. K. Chiu, T. K. Lau, T. N. Leung, L. C. Chan, A. Y. Y. Chan, P. Charoenkwan, I. S. L. Ng, H.-y. Law, E. S. K. Ma, et al.
MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis
PNAS, July 20, 2004; 101(29): 10762 - 10767.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J.-C. Lin, W.-Y. Wang, K. Y. Chen, Y.-H. Wei, W.-M. Liang, J.-S. Jan, and R.-S. Jiang
Quantification of Plasma Epstein-Barr Virus DNA in Patients with Advanced Nasopharyngeal Carcinoma
N. Engl. J. Med., June 10, 2004; 350(24): 2461 - 2470.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
B. TABACK and D. S. B. HOON
Circulating Nucleic Acids and Proteomics of Plasma/Serum: Clinical Utility
Ann. N.Y. Acad. Sci., June 1, 2004; 1022(1): 1 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
S. M. Krishna, S. James, J. Kattoor, and P. Balaram
Serum EBV DNA as a Biomarker in Primary Nasopharyngeal Carcinoma of Indian Origin
Jpn. J. Clin. Oncol., June 1, 2004; 34(6): 307 - 311.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
Y. Chang, S.-S. Chang, H.-H. Lee, S.-L. Doong, K. Takada, and C.-H. Tsai
Inhibition of the Epstein-Barr virus lytic cycle by Zta-targeted RNA interference
J. Gen. Virol., June 1, 2004; 85(6): 1371 - 1379.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
B. TABACK, S. J. O'DAY, and D. S.B. HOON
Quantification of Circulating DNA in the Plasma and Serum of Cancer Patients
Ann. N.Y. Acad. Sci., June 1, 2004; 1022(1): 17 - 24.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. L. Glaser, J. L. Hsu, and M. L. Gulley
Epstein-Barr Virus and Breast Cancer: State of the Evidence for Viral Carcinogenesis
Cancer Epidemiol. Biomarkers Prev., May 1, 2004; 13(5): 688 - 697.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T.-S. Wong, D. L.-W. Kwong, J. S.-T. Sham, W. I. Wei, Y.-L. Kwong, and A. P.-W. Yuen
Quantitative Plasma Hypermethylated DNA Markers of Undifferentiated Nasopharyngeal Carcinoma
Clin. Cancer Res., April 1, 2004; 10(7): 2401 - 2406.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. H. Yu, Y. M. D. Lo, G. M. Tse, K. C. A. Chan, A. B. W. Chan, K. C. K. Chow, T. K. F. Ma, A. C. Vlantis, S. F. Leung, C. A. van Hasselt, et al.
Quantitative Analysis of Cell-Free Epstein-Barr Virus DNA in Plasma of Patients with Nonnasopharyngeal Head and Neck Carcinomas
Clin. Cancer Res., March 1, 2004; 10(5): 1726 - 1732.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. von Knobloch, H. Brandt, A. J. Schrader, A. Heidenreich, and R. Hofmann
Molecular Serological Detection of DNA Alterations in Transitional Cell Carcinoma Is Highly Sensitive and Stage Independent
Clin. Cancer Res., February 1, 2004; 10(3): 988 - 993.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S.-f. Leung, J. S. Tam, A. T.C. Chan, B. Zee, L. Y.S. Chan, D. P. Huang, A. Van Hasselt, P. J. Johnson, and Y.M. D. Lo
Improved Accuracy of Detection of Nasopharyngeal Carcinoma by Combined Application of Circulating Epstein-Barr Virus DNA and Anti-Epstein-Barr Viral Capsid Antigen IgA Antibody
Clin. Chem., February 1, 2004; 50(2): 339 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. C. S. Cho, T. T. C. Yip, C. Yip, V. Yip, V. Thulasiraman, R. K. C. Ngan, T.-T. Yip, W.-H. Lau, J. S. K. Au, S. C. K. Law, et al.
Identification of Serum Amyloid A Protein As a Potentially Useful Biomarker to Monitor Relapse of Nasopharyngeal Cancer by Serum Proteomic Profiling
Clin. Cancer Res., January 1, 2004; 10(1): 43 - 52.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
A. M. Polstra, R. van den Burg, J. Goudsmit, and M. Cornelissen
Human Herpesvirus 8 Load in Matched Serum and Plasma Samples of Patients with AIDS-Associated Kaposi's Sarcoma
J. Clin. Microbiol., December 1, 2003; 41(12): 5488 - 5491.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
K.-F. Hsu, S.-C. Huang, J.-R. Hsiao, Y.-M. Cheng, S. P. H. Wang, and C.-Y. Chou
Clinical Significance of Serum Human Papillomavirus DNA in Cervical Carcinoma
Obstet. Gynecol., December 1, 2003; 102(6): 1344 - 1351.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
H. Asada, S. Miyagawa, Y. Sumikawa, Y. Yamaguchi, S. Itami, S. Suguri, M. Harada, Y. Tokura, S. Ishihara, S. Ohshima, et al.
CD4+ T-Lymphocyte-Induced Epstein-Barr Virus Reactivation in a Patient With Severe Hypersensitivity to Mosquito Bites and Epstein-Barr Virus-Infected NK Cell Lymphocytosis
Arch Dermatol, December 1, 2003; 139(12): 1601 - 1607.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
R. M. Wadowsky, S. Laus, M. Green, S. A. Webber, and D. Rowe
Measurement of Epstein-Barr Virus DNA Loads in Whole Blood and Plasma by TaqMan PCR and in Peripheral Blood Lymphocytes by Competitive PCR
J. Clin. Microbiol., November 1, 2003; 41(11): 5245 - 5249.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. W. H. To, K. C. A. Chan, S.-F. Leung, L. Y. S. Chan, K.-F. To, A. T. C. Chan, P. J. Johnson, and Y. M. D. Lo
Rapid Clearance of Plasma Epstein-Barr Virus DNA After Surgical Treatment of Nasopharyngeal Carcinoma
Clin. Cancer Res., August 1, 2003; 9(9): 3254 - 3259.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S.-f. Leung, Y. M. D. Lo, A. T. C. Chan, K.-f. To, E. To, L. Y. S. Chan, B. Zee, D. P. Huang, and P. J. Johnson
Disparity of Sensitivities in Detection of Radiation-Naive and Postirradiation Recurrent Nasopharyngeal Carcinoma of the Undifferentiated Type by Quantitative Analysis of Circulating Epstein-Barr Virus DNA1 ,2
Clin. Cancer Res., August 1, 2003; 9(9): 3431 - 3434.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K.C. A. Chan, J. Zhang, A. T.C. Chan, K. I.K. Lei, S.-F. Leung, L. Y.S. Chan, K. C.K. Chow, and Y.M. D. Lo
Molecular Characterization of Circulating EBV DNA in the Plasma of Nasopharyngeal Carcinoma and Lymphoma Patients
Cancer Res., May 1, 2003; 63(9): 2028 - 2032.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. H.M. Chan, K. M. Chow, A. T.C. Chan, C. B. Leung, L. Y.S. Chan, K. C.K. Chow, C. W. Lam, and Y.M. D. Lo
Quantitative Analysis of Pleural Fluid Cell-free DNA as a Tool for the Classification of Pleural Effusions
Clin. Chem., May 1, 2003; 49(5): 740 - 745.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Lu, H.-H. Chua, S.-Y. Chen, J.-Y. Chen, and C.-H. Tsai
Regulation of Matrix Metalloproteinase-1 by Epstein-Barr Virus Proteins
Cancer Res., January 1, 2003; 63(1): 256 - 262.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
D. Gius and C. N. Coleman
Treatment of Nasopharyngeal Cancer: Raising the "Barr"
J Natl Cancer Inst, November 6, 2002; 94(21): 1594 - 1595.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. T. C. Chan, Y. M. D. Lo, B. Zee, L. Y. S. Chan, B. B. Y. Ma, S.-F. Leung, F. Mo, M. Lai, S. Ho, D. P. Huang, et al.
Plasma Epstein-Barr Virus DNA and Residual Disease After Radiotherapy for Undifferentiated Nasopharyngeal Carcinoma
J Natl Cancer Inst, November 6, 2002; 94(21): 1614 - 1619.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
L. L. Dworkin, T. M. Gibler, and R. N. Van Gelder
Real-Time Quantitative Polymerase Chain Reaction Diagnosis of Infectious Posterior Uveitis
Arch Ophthalmol, November 1, 2002; 120(11): 1534 - 1539.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. J. Johnson and Y.M. D. Lo
Plasma Nucleic Acids in the Diagnosis and Management of Malignant Disease
Clin. Chem., August 1, 2002; 48(8): 1186 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W.-Y. Wang, Y.-C. Chien, J.-S. Jan, C.-M. Chueh, and J.-C. Lin
Consistent Sequence Variation of Epstein-Barr Virus Nuclear Antigen 1 in Primary Tumor and Peripheral Blood Cells of Patients with Nasopharyngeal Carcinoma
Clin. Cancer Res., August 1, 2002; 8(8): 2586 - 2590.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. H. M. Tong, R. K. Y. Tsang, K.-W. Lo, J. K. S. Woo, J. Kwong, M. W. Y. Chan, A. R. Chang, C. A. van Hasselt, D. P. Huang, and K.-F. To
Quantitative Epstein-Barr Virus DNA Analysis and Detection of Gene Promoter Hypermethylation in Nasopharyngeal (NP) Brushing Samples from Patients with NP Carcinoma
Clin. Cancer Res., August 1, 2002; 8(8): 2612 - 2619.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
A. T. C. Chan, P. M. L. Teo, and P. J. Johnson
Nasopharyngeal carcinoma
Ann. Onc., July 1, 2002; 13(7): 1007 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J M Silva, R Rodriguez, J M Garcia, C Munoz, J Silva, G Dominguez, M Provencio, P Espana, and F Bonilla
Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells
Gut, April 1, 2002; 50(4): 530 - 534.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. Dominguez, J. Carballido, J. Silva, J. M. Silva, J. M. Garcia, J. Menendez, M. Provencio, P. Espana, and F. Bonilla
p14ARF Promoter Hypermethylation in Plasma DNA as an Indicator of Disease Recurrence in Bladder Cancer Patients
Clin. Cancer Res., April 1, 2002; 8(4): 980 - 985.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. K. C. Ngan, T. T. C. Yip, W.-W. Cheng, J. K. C. Chan, W. C. S. Cho, V. W. S. Ma, K.-K. Wan, S.-K. Au, C.-K. Law, and W.-H. Lau
Circulating Epstein-Barr Virus DNA in Serum of Patients with Lymphoepithelioma-like Carcinoma of the Lung: A Potential Surrogate Marker for Monitoring Disease
Clin. Cancer Res., April 1, 2002; 8(4): 986 - 994.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
I. M. Mackay, K. E. Arden, and A. Nitsche
Real-time PCR in virology
Nucleic Acids Res., March 15, 2002; 30(6): 1292 - 1305.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. M. Dong, S. I. Pai, S.-H. Rha, A. Hildesheim, R. J. Kurman, P. E. Schwartz, R. Mortel, L. McGowan, M. D. Greenberg, W. A. Barnes, et al.
Detection and Quantitation of Human Papillomavirus DNA in the Plasma of Patients with Cervical Carcinoma
Cancer Epidemiol. Biomarkers Prev., January 1, 2002; 11(1): 3 - 6.
[Abstract] [Full Text]

Home page