Cancer Research Targets Advances in Breast Cancer Research
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[Cancer Research 59, 1408-1411, April 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 1408-1411, April 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Localization of PS6K to Chromosomal Region 17q23 and Determination of Its Amplification in Breast Cancer1

Fergus J. Couch, Xiao-Yang Wang, Guo-Jun Wu, Junqi Qian, Robert B. Jenkins and C. David James2

Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905

The application of comparative genomic hybridization to the analysis of genetic abnormalities in breast carcinoma has consistently revealed that chromosome region 17q22–24 is a frequent site of gene amplification in this type of cancer. As part of an examination of expressed sequence tags for novel amplified genes in this region, we identified PS6K amplifications in both breast tumor tissues and cell lines. PS6K was localized to 17q23 and encodes a serine-threonine kinase whose activation is thought to regulate a wide array of cellular processes involved in the mitogenic response including protein synthesis, translation of specific mRNA species, and cell cycle progression from G1 to S phase. Northern and Western analyses revealed that amplification of this gene was accompanied by corresponding increases in mRNA and protein expression, respectively. These data represent the first determination of a gene amplification within 17q22–24 in breast cancer and suggest an oncogenic activity for PS6K.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
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Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.