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[Cancer Research 59, 2041-2044, May 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 2041-2044, May 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Centrosomal Kinase AIK1 Is Overexpressed in Invasive Ductal Carcinoma of the Breast1

Takuji Tanaka, Masashi Kimura, Kengo Matsunaga, Daizo Fukada, Hideki Mori and Yukio Okano2

Department of Pathology, Kanazawa Medical University [T. T.] Uchinadamachi 920-0293, Japan, and Departments of Pathology [K. M., H. M.], Surgery [D. F.], and Molecular Pathobiochemistry [M. K., Y. O.], Gifu University School of Medicine, Gifu 500-8705, Japan

A centrosomal serine/threonine kinase, AIK13/ breast tumor amplified kinase/aurora2, which was recently identified as an oncogene, shows high amino acid identity with chromosome segregation kinases, fly Aurora, and yeast Ipl1. Immunohistochemical analyses of invasive ductal adenocarcinomas of the breast revealed that overexpression of AIK1 was observed in 94% of the cases, irrespective of the histopathological type, whereas the protein was not detected in normal ductal and lobular cells. Benign breast lesions including fibrocystic disease and fibroadenoma (epithelial components) displayed weakly detectable AIK1 expression in part of the lesions. This is the first immunohistochemical report of AIK1 expression in primary human breast carcinomas. Although the physiological function(s) of AIK1 kinase during cell division remains to be determined, the markedly high positivity of AIK1 staining in the cancer lesions suggested a possible involvement of its overexpression in the tumorigenesis of some of breast cancer cells.




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