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Replication-competent, Nonneuroinvasive Genetically Engineered Herpes Virus Is Highly Effective in the Treatment of Therapy-resistant Experimental Human Tumors¹

Department of Radiation and Cellular Oncology, The University of Chicago Hospitals Duchossois Center for Advanced Medicine, Chicago, Illinois 60637 [S. J. A., S. M. C., S. Y. Y., R. R. W.]; Brain Tumor Research Laboratories, Division of Neurosurgery, Department of Surgery [G. Y. G., J. M. M.], and, Division of Clinical Virology, Department of Pediatrics, [R. J. W.] University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294-0006; and The Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago, Chicago, Illinois 60637 [B. R.]

A genetically engineered, nonneurotropic herpes simplex virus (R7020) with a proven safety profile in both animals and humans was found effective in the treatment of large xenotransplanted tumors arising from a radiation- and chemotherapy-resistant human epidermoid carcinoma and a hormone-refractory prostate adenocarcinoma. R7020 replicated to high titer and caused rapid regression of the human tumor xenografts. Tumor destruction was accelerated in animals given both R7020 and fractionated ionizing radiation. Tumors arising from cells surviving one treatment with R7020 were fully susceptible to a second dose of virus. We conclude R7020 is an effective antitumor agent for non-central nervous system tumor xenografts with an excellent safety profile.

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