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[Cancer Research 60, 13-17, January 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Molecular Cloning and Characterization of Human MAWD, a Novel Protein Containing WD-40 Repeats Frequently Overexpressed in Breast Cancer1

Satoru Matsuda2, Ryu Katsumata, Takahito Okuda, Tatsuyoshi Yamamoto, Kou Miyazaki, Takeshi Senga, Kazuya Machida, Aye Aye Thant, Shigekazu Nakatsugawa and Michinari Hamaguchi

Department of Molecular Pathogenesis [S. M., R. K., T. O., K. M., T. S., A. A. T., M. H.] and First Department of Surgery [T. Y., K. M.], Nagoya University School of Medicine, Nagoya 466-8550, Japan, and Division of Radiology, Nagoya University, Daiko Medical Center, Nagoya 461-0047 Japan [S. N.]

A full-length cDNA clone encoding a novel protein containing WD-40 repeats, which were frequently involved in protein-protein interactions, was isolated and sequenced. This clone had a predicted open reading frame (ORF) encoding 350 amino acids possessing six repeats of WD-40 motif. It was most closely homologous to TRIP-1, a phosphorylation substrate of the transforming growth factor-ß type II receptor. In the process of characterizing the function of the new gene product, we found that overexpression of the gene seemed to activate mitogen-activated protein kinase and to promote anchorage-independent growth of the cells. Moreover, the gene product was frequently overexpressed in human tumor breast tissues compared with their normal breast tissues, suggesting that the gene might be involved in the tumor progression. Radiation hybrid mapping placed the gene into human chromosome 12q11–12 near the marker D12S1593.




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