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Tumor Suppression and Sensitization to Tumor Necrosis Factor -induced Apoptosis by an Interferon-inducible Protein, p202, in Breast Cancer Cells¹

Department of Cancer Biology, Section of Molecular Cell Biology [Y. W., D-H. Y., B. S., J. D., S-Y. L., M-C. H.], Department of Surgical Oncology [D-H. Y., M-C. H.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

p202, an IFN-inducible protein, interacts with several important regulatory proteins, leading to growth arrest or differentiation. In this report, we demonstrate that, in addition to inhibiting in vitro cell growth, p202 can also suppress the tumorigenicity of breast cancer cells in vivo. Furthermore, we found that p202 expression could sensitize breast cancer cells to apoptosis induced by tumor necrosis factor treatment. One possible mechanism contributing to this sensitization is the inactivation of nuclear factor-B by its interaction with p202. These results provide a scientific basis for a novel therapeutic strategy that combines p202 and tumor necrosis factor treatment against breast cancer.

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