Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention Tumor Immunology: New Perspectives
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[Cancer Research 60, 70-73, January 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

A Distinct Tumor Suppressor Gene Locus on Chromosome 15q21.1 in Sporadic Form of Colorectal Cancer1

Won Sang Park, Jik Young Park, Ro Ra Oh, Nam Jin Yoo, Sug Hyung Lee, Min Sun Shin, Hun Kyung Lee, Seoyoung Han, Sungjoo Kim Yoon, Su Young Kim, Chan Choi, Pum Joon Kim, Seong Taek Oh and Jung Young Lee2

Department of Pathology and Cancer Research Institute [W. S. P., J. Y. P., R. R. O., N. J. Y., S. H. L., M. S. S., H. K. L., S. H., S. Y. K., P. J. K., J. Y. L.], Department of Surgery [S. T. O.], and Research Institute of Molecular Genetics [S. K. Y.], College of Medicine, The Catholic University of Korea, Seoul 137-701; and Department of Pathology, Chonnam University Medical School, Kwangju 501-190 [C. C.], Korea

The SM1311 family is an Ashkenazi family with dominantly inherited predisposition to colorectal adenomas and carcinomas and has a high-penetrance locus in chromosome 15q, with a multipoint logarithm of the odds score of 3.06 at marker D15S118. In the present study, we performed a high-density loss of heterozygosity study with 13 polymorphic microsatellite markers, including D15S118, spanning 15q15.3-q22.1, on 70 cases of the sporadic form of colorectal tumors. Our deletion mapping data showed a locus at D15S968 in chromosomal sub-band 15q21.1 may harbor a tumor suppressor gene in an area <0.521 Mb in physical map distance defined by markers D15S514 and D15S222. THBS1, 0.185 Mb proximal to D15S968, is the nearest known gene to this specific narrow loss of heterozygosity region. Thus, we speculate that THBS1 might be the most probable candidate gene involved in colorectal cancer carcinogenesis.




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