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Department of Internal Medicine I, University of Ulm, 89081 Ulm, Germany [C. W., S. H., F. M-P., G. A., T. M. G.]; Hungarian Academy of Sciences, University of Budapest, 1450 Budapest, Hungary [B. B.]; Department of Medicine B, University of Münster, 48129 Münster, Germany [M. M. L., M. R.]; Miyazaki Medical College, Kiyotake, Miyazaki 889-1692, Japan [T. I.]
We report the characterization of a novel serine protease of the chymotrypsin family, recently isolated by cDNA-representational difference analysis, as a gene overexpressed in pancreatic cancer. The 2.3-kb mRNA of the gene, named TMPRSS3, is strongly expressed in a subset of pancreatic cancer and various other cancer tissues, and its expression correlates with the metastatic potential of the clonal SUIT-2 pancreatic cancer cell lines. The deduced polypeptide sequence consists of 437 amino acids and exhibits all of the structural features characteristic of serine proteases with trypsin-like activity. TMPRSS3 is membrane bound with a NH2-terminal signal-anchor sequence and a glycosylated extracellular region containing the serine protease domain. Thus, TMPRSS3 is a novel membrane-bound serine protease overexpressed in cancer, which may be of importance for processes involved in metastasis formation and tumor invasion.
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