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[Cancer Research 60, 2831-2835, June 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Loss of p53 in Benzene-induced Thymic Lymphomas in p53+/- Mice: Evidence of Chromosomal Recombination

Scott E. Boley, Elizabeth E. Anderson, John E. French, Lawrence A. Donehower, Dana B. Walker and Leslie Recio1

Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709 [S. E. B., E. E. A., L. R.]; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 [J. E. F.]; Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030 [L. A. D.]; and United States Environmental Protection Agency, Research Triangle Park, North Carolina 27709 [D. B. W.]

The purpose of this study was to examine the role of chromosomal recombination in mediating p53 loss in benzene-induced thymic lymphomas in C57BL/6-Trp53 haploinsufficient (N5) mice (p53+/- mice). We characterized loss of heterozygosity (LOH) on chromosome 11 using seven microsatellite markers in 27 benzene-induced and 6 spontaneous thymic lymphomas. Eleven patterns of LOH were found between the induced and spontaneous tumors, with only one pattern being in common between the tumor groups. Nearly 90% (24 of 27) of benzene-induced tumors exhibited loss of the functional p53 allele locus, and 83% (20 of 24) of these tumors retained two copies of the disrupted p53 allele. The results indicate that benzene induces a high frequency of LOH on chromosome 11 in p53+/- mice, likely mediated by aberrant chromosomal recombination.




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