Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boley, S. E.
Right arrow Articles by Recio, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boley, S. E.
Right arrow Articles by Recio, L.
[Cancer Research 60, 2831-2835, June 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Loss of p53 in Benzene-induced Thymic Lymphomas in p53+/- Mice: Evidence of Chromosomal Recombination

Scott E. Boley, Elizabeth E. Anderson, John E. French, Lawrence A. Donehower, Dana B. Walker and Leslie Recio1

Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709 [S. E. B., E. E. A., L. R.]; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 [J. E. F.]; Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030 [L. A. D.]; and United States Environmental Protection Agency, Research Triangle Park, North Carolina 27709 [D. B. W.]

The purpose of this study was to examine the role of chromosomal recombination in mediating p53 loss in benzene-induced thymic lymphomas in C57BL/6-Trp53 haploinsufficient (N5) mice (p53+/- mice). We characterized loss of heterozygosity (LOH) on chromosome 11 using seven microsatellite markers in 27 benzene-induced and 6 spontaneous thymic lymphomas. Eleven patterns of LOH were found between the induced and spontaneous tumors, with only one pattern being in common between the tumor groups. Nearly 90% (24 of 27) of benzene-induced tumors exhibited loss of the functional p53 allele locus, and 83% (20 of 24) of these tumors retained two copies of the disrupted p53 allele. The results indicate that benzene induces a high frequency of LOH on chromosome 11 in p53+/- mice, likely mediated by aberrant chromosomal recombination.




This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
E. A. H. Neuwirth, M. Honma, and A. J. Grosovsky
Interchromosomal Crossover in Human Cells Is Associated with Long Gene Conversion Tracts
Mol. Cell. Biol., August 1, 2007; 27(15): 5261 - 5274.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
D. Jacobson-Kram, F. D. Sistare, and A. C. Jacobs
Use of Transgenic Mice in Carcinogenicity Hazard Assessment
Toxicol Pathol, January 1, 2004; 32(1_suppl): 49 - 52.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
F. Ide, M. Kitada, H. Sakashita, K. Kusama, K. Tanaka, and T. Ishikawa
p53 Haploinsufficiency Profoundly Accelerates the Onset of Tongue Tumors in Mice Lacking the Xeroderma Pigmentosum Group A Gene
Am. J. Pathol., November 1, 2003; 163(5): 1729 - 1733.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
L. M. Winn
Homologous Recombination Initiated by Benzene Metabolites: A Potential Role of Oxidative Stress
Toxicol. Sci., March 1, 2003; 72(1): 143 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
E. Floyd, P. Mann, G. Long, and R. Ochoa
The Trp53 Hemizygous Mouse in Pharmaceutical Development: Points to Consider for Pathologists
Toxicol Pathol, January 1, 2002; 30(1): 147 - 156.
[Abstract] [PDF]

Home page
 MutagenesisHome page
L. N. Healy, L. J. Pluta, R.A. James, D. B. Janszen, D. Torous, J. E. French, and L. Recio
Induction and time-dependent accumulation of micronuclei in peripheral blood of transgenic p53+/- mice, Tg.AC (v-Ha-ras) and parental wild-type (C57BL/6 and FVB/N) mice exposed to benzene by inhalation
Mutagenesis, March 1, 2001; 16(2): 163 - 168.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. E. French, G. D. Lacks, C. Trempus, J. K. Dunnick, J. Foley, J. Mahler, R. R. Tice, and R. W. Tennant
Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent
Carcinogenesis, January 1, 2001; 22(1): 99 - 106.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
S. Venkatachalam, S. D. Tyner, C. R. Pickering, S. Boley, L. Recio, J. E. French, and L. A. Donehower
Is p53 Haploinsufficient for Tumor Suppression? Implications for the p53+/- Mouse Model in Carcinogenicity Testing
Toxicol Pathol, January 1, 2001; 29(1_suppl): 147 - 154.
[Abstract] [PDF]

Home page
 CarcinogenesisHome page
H. Zhang, G. Marra, J. Jiricny, V. M. Maher, and J.J. McCormick
Mismatch repair is required for O6-methylguanine-induced homologous recombination in human fibroblasts
Carcinogenesis, September 1, 2000; 21(9): 1639 - 1646.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.