This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Castells, A. Articles by Rustgi, A. K. Search for Related Content PubMed PubMed Citation Articles by Castells, A. Articles by Rustgi, A. K.

A Region of Deletion on Chromosome 22q13 Is Common to Human Breast and Colorectal Cancers¹

Molecular Neurogenetics Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 [A. C., J. F. G., V. R.], and Gastroenterology Division [A. K. R.], Genetics Department [A. K. R.], and Cancer Center [A. K. R.], University of Pennsylvania, Philadelphia, Pennsylvania 19104-2144

Chromosomal allelic losses have varying frequency in breast cancer, with key regions including chromosomes 1, 3p, 7q, 9p, 16q, 17, and 22q. Recently, we have been able to map a new target region of allelic loss on chromosome 22q involved in colorectal cancer. The aim of the current investigation was to determine whether this target region may also be involved in human breast carcinogenesis. Thirty-six pairs of matched normal and tumor specimens from breast cancer patients, as well as eight breast cancer-derived cell lines, were genotyped using 17 microsatellite markers spanning chromosome 22q. Allelic deletion was found in 19 of 36 tumors (53%), and the pattern observed in those cases with partial losses was consistent with a region flanked by D22S1171 and D22S928. This interval overlaps that identified in colorectal cancer and comprises nearly 1.1 Mb. This study provides evidence of a common region of deletion on chromosome 22q13 involved in both breast and colorectal cancers and underscores the existence of putative tumor suppressor gene(s) at this location.

This article has been cited by other articles:

				C. N. Johnstone, P. S. Mongroo, A. S. Rich, M. Schupp, M. J. Bowser, A. S. deLemos, J. W. Tobias, Y. Liu, G. E. Hannigan, and A. K. Rustgi Parvin- Inhibits Breast Cancer Tumorigenicity and Promotes CDK9-Mediated Peroxisome Proliferator-Activated Receptor Gamma 1 Phosphorylation Mol. Cell. Biol., January 15, 2008; 28(2): 687 - 704. [Abstract] [Full Text] [PDF]

				J. M. Hartikainen, H. Tuhkanen, V. Kataja, M. Eskelinen, M. Uusitupa, V.-M. Kosma, and A. Mannermaa Refinement of the 22q12-q13 Breast Cancer-Associated Region: Evidence of TMPRSS6 as a Candidate Gene in an Eastern Finnish Population Clin. Cancer Res., March 1, 2006; 12(5): 1454 - 1462. [Abstract] [Full Text] [PDF]

				H. Orita, N. Sakamoto, Y. Ajioka, T. Terai, O. Hino, N. Sato, T. Shimoda, T. Kamano, M. Tsurumaru, and H. Fujii Allelic loss analysis of early-stage flat-type colorectal tumors Ann. Onc., January 1, 2006; 17(1): 43 - 49. [Abstract] [Full Text] [PDF]

				J. P. Mathai, M. Germain, and G. C. Shore BH3-only BIK Regulates BAX,BAK-dependent Release of Ca2+ from Endoplasmic Reticulum Stores and Mitochondrial Apoptosis during Stress-induced Cell Death J. Biol. Chem., June 24, 2005; 280(25): 23829 - 23836. [Abstract] [Full Text] [PDF]

				Y. M. Li, Y. Wen, B. P. Zhou, H.-P. Kuo, Q. Ding, and M.-C. Hung Enhancement of Bik Antitumor Effect by Bik Mutants Cancer Res., November 15, 2003; 63(22): 7630 - 7633. [Abstract] [Full Text] [PDF]

				A. R. Whitney, M. Diehn, S. J. Popper, A. A. Alizadeh, J. C. Boldrick, D. A. Relman, and P. O. Brown Individuality and variation in gene expression patterns in human blood PNAS, February 18, 2003; 100(4): 1896 - 1901. [Abstract] [Full Text] [PDF]

				G. Velasco, S. Cal, V. Quesada, L. M. Sanchez, and C. Lopez-Otin Matriptase-2, a Membrane-bound Mosaic Serine Proteinase Predominantly Expressed in Human Liver and Showing Degrading Activity against Extracellular Matrix Proteins J. Biol. Chem., September 27, 2002; 277(40): 37637 - 37646. [Abstract] [Full Text] [PDF]

				Y. Zou, H. Peng, B. Zhou, Y. Wen, S.-C. Wang, E.-M. Tsai, and M.-C. Hung Systemic Tumor Suppression by the Proapoptotic Gene bik Cancer Res., January 1, 2002; 62(1): 8 - 12. [Abstract] [Full Text] [PDF]

				A. Wild, P. Langer, A. Ramaswamy, B. Chaloupka, and D. K. Bartsch A Novel Insulinoma Tumor Suppressor Gene Locus on Chromosome 22q with Potential Prognostic Implications J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5782 - 5787. [Abstract] [Full Text] [PDF]