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[Cancer Research 60, 3143-3146, June 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Genomic Structure of the Human ING1 Gene and Tumor-specific Mutations Detected in Head and Neck Squamous Cell Carcinomas1

Mehmet Gunduz, Mamoru Ouchida, Kunihiro Fukushima, Hiroko Hanafusa, Tsutomu Etani, Shinji Nishioka, Kazunori Nishizaki and Kenji Shimizu2

Department of Otolaryngology [M. G., K. F., T. E., S. N., K. N.] and Department of Molecular Genetics, Institute of Cellular and Molecular Biology [M. O., H. H., K. S.], Okayama University Medical School, Okayama 700-8558, Japan

We characterized the genomic structure of the human ING1 gene, a candidate tumor suppressor gene, and found that the gene has three exons. We also demonstrated that four mRNA variants were transcribed from three different promoter regions. Of 34 informative cases of head and neck squamous cell carcinoma, 68% of tumors showed loss of heterozygosity at chromosome 13q33–34, where the ING1 gene is located. Here we present the first report that three missense mutations and three silent changes were detected in the ING1 gene in 6 of 23 tumors with allelic loss at the 13q33–34 region. These missense mutations were found within the PHD finger domain and nuclear localization motif in ING1 protein, probably abrogating the normal function.




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Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
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Copyright © 2000 by the American Association for Cancer Research.