Cancer Research Cancer Medicine 8 EMT and Cancer Progression and Treatment
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hussain, S. P.
Right arrow Articles by Harris, C. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hussain, S. P.
Right arrow Articles by Harris, C. C.
[Cancer Research 60, 3333-3337, July 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Increased p53 Mutation Load in Noncancerous Colon Tissue from Ulcerative Colitis: A Cancer-prone Chronic Inflammatory Disease

S. Perwez Hussain, Paul Amstad1, Kamran Raja, Stefan Ambs2, Makoto Nagashima, William P. Bennett3, Peter G. Shields, Amy-Joan Ham4, James A. Swenberg4, Aizen J. Marrogi and Curtis C. Harris5

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892

Ulcerative colitis (UC) is a chronic inflammatory disease that produces reactive oxygen and nitrogen species and increases the risk of colorectal cancer (CRC). The p53 tumor suppressor gene is frequently mutated in UC-associated dysplastic lesions and CRC. We are exploring the hypothesis that p53 mutations in the nontumorous colonic tissue in noncancerous UC cases indicate genetic damage from exposure to exogenous and endogenous carcinogens and may identify individuals at increased cancer risk. We are reporting, for the first time, the frequency of specific p53 mutated alleles in nontumorous colon tissue from donors either with or without UC by using a highly sensitive genotypic mutation assay. Higher p53 mutation frequencies of both G:C to A:T transitions at the CpG site of codon 248 and C:G to T:A transitions at codon 247 were observed in colon from UC cases when compared with normal adult controls (P = 0.001 and P = 0.001, respectively). In the UC cases, higher p53 codon 247 and 248 mutation frequencies were observed in the inflamed lesional regions when compared with the nonlesional regions of their colon (P < 0.001 and P = 0.001). The colonic nitric oxide synthase-2 activity was higher in UC cases than in non-UC adult controls (P = 0.02). Our data are consistent with the hypothesis that a higher frequency of p53 mutant cells can be generated under oxidative stress in people with UC. The increased frequency of specific p53 mutated alleles in noncancerous UC colon tissue may confer susceptibility to the development of CRC in an inflammatory microenvironment.




This article has been cited by other articles:


Home page
 GutHome page
E. H Warren
Genetic risk for colitis-associated colorectal cancer
Gut, September 1, 2009; 58(9): 1177 - 1179.
[Full Text] [PDF]

Home page
 Cancer Prevention ResearchHome page
K. Konishi, L. Shen, J. Jelinek, Y. Watanabe, S. Ahmed, K. Kaneko, M. Kogo, T. Takano, M. Imawari, S. R. Hamilton, et al.
Concordant DNA Methylation in Synchronous Colorectal Carcinomas
Cancer Prevention Research, September 1, 2009; 2(9): 814 - 822.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
F. Colotta, P. Allavena, A. Sica, C. Garlanda, and A. Mantovani
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
Carcinogenesis, July 1, 2009; 30(7): 1073 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol Ind HealthHome page
D. Alley, S Langley-Turnbaugh, N. Gordon, J. Wise, G Van Epps, and A Jalbert
The effect of PM10 on human lung fibroblasts
Toxicology and Industrial Health, March 1, 2009; 25(2): 111 - 120.
[Abstract] [PDF]

Home page
 CarcinogenesisHome page
Y. Tao, J. Hart, L. Lichtenstein, L. J. Joseph, M. J. Ciancio, S. Hu, E. B. Chang, and M. Bissonnette
Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer
Carcinogenesis, January 1, 2009; 30(1): 175 - 182.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. A. Loeb and C. C. Harris
Advances in Chemical Carcinogenesis: A Historical Review and Prospective
Cancer Res., September 1, 2008; 68(17): 6863 - 6872.
[Full Text] [PDF]

Home page
 CarcinogenesisHome page
W.-C. L. Chang, R. A. Coudry, M. L. Clapper, X. Zhang, K.-L. Williams, C. S. Spittle, T. Li, and H. S. Cooper
Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
Carcinogenesis, November 1, 2007; 28(11): 2375 - 2381.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
X. Huang, S. Pateromichelakis, A. Hills, M. Sherriff, A. Lyons, J. Langdon, E. Odell, P. Morgan, J. Harrison, and M. Partridge
p53 Mutations in Deep Tissues Are More Strongly Associated with Recurrence than Mutation-Positive Mucosal Margins
Clin. Cancer Res., October 15, 2007; 13(20): 6099 - 6106.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Ying, A. B. Hofseth, D. D. Browning, M. Nagarkatti, P. S. Nagarkatti, and L. J. Hofseth
Nitric Oxide Inactivates the Retinoblastoma Pathway in Chronic Inflammation
Cancer Res., October 1, 2007; 67(19): 9286 - 9293.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Gommeaux, C. Cano, S. Garcia, M. Gironella, S. Pietri, M. Culcasi, M.-J. Pebusque, B. Malissen, N. Dusetti, J. Iovanna, et al.
Colitis and Colitis-Associated Cancer Are Exacerbated in Mice Deficient for Tumor Protein 53-Induced Nuclear Protein 1
Mol. Cell. Biol., March 15, 2007; 27(6): 2215 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. H. Bielas, K. R. Loeb, B. P. Rubin, L. D. True, and L. A. Loeb
From the Cover: Human cancers express a mutator phenotype
PNAS, November 28, 2006; 103(48): 18238 - 18242.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D.-H. Lee, R. S. Esworthy, C. Chu, G. P. Pfeifer, and F.-F. Chu
Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases.
Cancer Res., October 15, 2006; 66(20): 9845 - 9851.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Hagiwara, L. E. Mechanic, G. E. Trivers, H. L. Cawley, M. Taga, E. D. Bowman, K. Kumamoto, P. He, M. Bernard, S. Doja, et al.
Quantitative Detection of p53 Mutations in Plasma DNA from Tobacco Smokers
Cancer Res., August 15, 2006; 66(16): 8309 - 8317.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Q. Du, K. S. Park, Z. Guo, P. He, M. Nagashima, L. Shao, R. Sahai, D. A. Geller, and S. P. Hussain
Regulation of Human Nitric Oxide Synthase 2 Expression by Wnt {beta}-Catenin Signaling.
Cancer Res., July 15, 2006; 66(14): 7024 - 7031.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. Hanada, T. Kobayashi, T. Chinen, K. Saeki, H. Takaki, K. Koga, Y. Minoda, T. Sanada, T. Yoshioka, H. Mimata, et al.
IFN{gamma}-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
J. Exp. Med., June 12, 2006; 203(6): 1391 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y. Sato, S. Takahashi, Y. Kinouchi, M. Shiraki, K. Endo, Y. Matsumura, Y. Kakuta, M. Tosa, A. Motida, H. Abe, et al.
IL-10 deficiency leads to somatic mutations in a model of IBD
Carcinogenesis, May 1, 2006; 27(5): 1068 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
S. P. Hussain and C. C. Harris
p53 Biological Network: Chronic Inflammation and Cancer
Am. Assoc. Cancer Res. Educ. Book, April 1, 2006; 2006(1): 249 - 254.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Staib, A. I. Robles, L. Varticovski, X. W. Wang, B. R. Zeeberg, M. Sirotin, V. B. Zhurkin, L. J. Hofseth, S. P. Hussain, J. N. Weinstein, et al.
The p53 Tumor Suppressor Network Is a Key Responder to Microenvironmental Components of Chronic Inflammatory Stress
Cancer Res., November 15, 2005; 65(22): 10255 - 10264.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Ying, J. Marino, S. P. Hussain, M. A. Khan, S. You, A. B. Hofseth, G. E. Trivers, D. A. Dixon, C. C. Harris, and L. J. Hofseth
Chronic Inflammation Promotes Retinoblastoma Protein Hyperphosphorylation and E2F1 Activation
Cancer Res., October 15, 2005; 65(20): 9132 - 9136.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
C R Boland, M G Luciani, C Gasche, and A Goel
INFECTION, INFLAMMATION, AND GASTROINTESTINAL CANCER
Gut, September 1, 2005; 54(9): 1321 - 1331.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. M. Lakshmi, W. M. Nauseef, and T. V. Zenser
Myeloperoxidase Potentiates Nitric Oxide-mediated Nitrosation
J. Biol. Chem., January 21, 2005; 280(3): 1746 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. Suzuki, Y. Ito, K. Wakai, M. Kawado, S. Hashimoto, H. Toyoshima, M. Kojima, S. Tokudome, N. Hayakawa, Y. Watanabe, et al.
Serum Oxidized Low-Density Lipoprotein Levels and Risk of Colorectal Cancer: A Case-Control Study Nested in the Japan Collaborative Cohort Study
Cancer Epidemiol. Biomarkers Prev., November 1, 2004; 13(11): 1781 - 1787.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Ono, H. Ikehata, V. P. Pithani, Y. Uehara, Y. Chen, Y. Kinouchi, T. Shimosegawa, and Y. Hosoi
Spontaneous Mutations in Digestive Tract of Old Mice Show Tissue-Specific Patterns of Genomic Instability
Cancer Res., October 1, 2004; 64(19): 6919 - 6923.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
L. J. Hofseth
The adaptive imbalance to genotoxic stress: genome guardians rear their ugly heads
Carcinogenesis, October 1, 2004; 25(10): 1787 - 1793.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
F. L. Martin and K. T. Semple
Environmental health impacts: occurrence, exposure and significance, Lancaster University, UK, 9-10 September 2003
Mutagenesis, September 1, 2004; 19(5): 423 - 429.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. H. Itzkowitz and X. Yio
Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G7 - G17.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
S Fujii, T Fujimori, H Kawamata, J Takeda, K Kitajima, F Omotehara, T Kaihara, T Kusaka, K Ichikawa, Y Ohkura, et al.
Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium
Gut, May 1, 2004; 53(5): 710 - 716.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. J. Hofseth, A. I. Robles, Q. Yang, X. W. Wang, S. P. Hussain, and C. Harris
p53: At the Crossroads of Molecular Carcinogenesis and Molecular Epidemiology
Chest, May 1, 2004; 125(5_suppl): 83S - 85S.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. Calabrese, S. Tavare, and D. Shibata
Pretumor Progression: Clonal Evolution of Human Stem Cell Populations
Am. J. Pathol., April 1, 2004; 164(4): 1337 - 1346.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Matsumoto, T. Yoshida, and I. Okayasu
High Epithelial and Stromal Genetic Instability of Chromosome 17 in Ulcerative Colitis-associated Carcinogenesis
Cancer Res., October 1, 2003; 63(19): 6158 - 6161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
O. Gallo, N. Schiavone, L. Papucci, I. Sardi, L. Magnelli, A. Franchi, E. Masini, and S. Capaccioli
Down-Regulation of Nitric Oxide Synthase-2 and Cyclooxygenase-2 Pathways by p53 in Squamous Cell Carcinoma
Am. J. Pathol., August 1, 2003; 163(2): 723 - 732.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Ezaki, M. Watanabe, N. Inoue, T. Kanai, H. Ogata, Y. Iwao, H. Ishii, and T. Hibi
A Specific Genetic Alteration on Chromosome 6 in Ulcerative Colitis-associated Colorectal Cancers
Cancer Res., July 1, 2003; 63(13): 3747 - 3749.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. N. Seril, J. Liao, G.-Y. Yang, and C. S. Yang
Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models
Carcinogenesis, March 1, 2003; 24(3): 353 - 362.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-H. Lee, D. K. Chang, A. Goel, C. R. Boland, W. Bugbee, D. L. Boyle, and G. S. Firestein
Microsatellite Instability and Suppressed DNA Repair Enzyme Expression in Rheumatoid Arthritis
J. Immunol., February 15, 2003; 170(4): 2214 - 2220.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. J. Hofseth, S.'i. Saito, S. P. Hussain, M. G. Espey, K. M. Miranda, Y. Araki, C. Jhappan, Y. Higashimoto, P. He, S. P. Linke, et al.
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
PNAS, January 7, 2003; 100(1): 143 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D.-H. Lee, T. R. O'Connor, and G. P. Pfeifer
Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells
Nucleic Acids Res., August 15, 2002; 30(16): 3566 - 3573.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Yamanishi, D. L. Boyle, S. Rosengren, D. R. Green, N. J. Zvaifler, and G. S. Firestein
Regional analysis of p53 mutations in rheumatoid arthritis synovium
PNAS, July 23, 2002; 99(15): 10025 - 10030.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. N. Seril, J. Liao, K.-L. K. Ho, C. S. Yang, and G.-Y. Yang
Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine
Carcinogenesis, June 1, 2002; 23(6): 993 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
K. Hemminki, Y. Jiang, X. Ma, K. Yang, L. Egevad, and P. Lindblad
Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients: relation to dietary and other factors
Carcinogenesis, May 1, 2002; 23(5): 809 - 815.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Sato, N. Harpaz, D. Shibata, Y. Xu, J. Yin, Y. Mori, T.-T. Zou, S. Wang, K. Desai, A. Leytin, et al.
Hypermethylation of the p14ARF Gene in Ulcerative Colitis-associated Colorectal Carcinogenesis
Cancer Res., February 1, 2002; 62(4): 1148 - 1151.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Ahn and H. Ohshima
Suppression of Intestinal Polyposis in ApcMin/+ Mice by Inhibiting Nitric Oxide Production
Cancer Res., December 1, 2001; 61(23): 8357 - 8360.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. J. Marrogi, M. A. Khan, H. E. van Gijssel, J. A. Welsh, H. Rahim, A. J. Demetris, K. V. Kowdley, S. P. Hussain, J. Nair, H. Bartsch, et al.
Oxidative Stress and p53 Mutations in the Carcinogenesis of Iron Overload-Associated Hepatocellular Carcinoma
J Natl Cancer Inst, November 7, 2001; 93(21): 1652 - 1655.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Jaiswal, N. F. LaRusso, and G. J. Gores
Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis
Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G626 - G634.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. P. Hussain, P. Amstad, K. Raja, M. Sawyer, L. Hofseth, P. G. Shields, A. Hewer, D. H. Phillips, D. Ryberg, A. Haugen, et al.
Mutability of p53 Hotspot Codons to Benzo(a)pyrene Diol Epoxide (BPDE) and the Frequency of p53 Mutations in Nontumorous Human Lung
Cancer Res., September 1, 2001; 61(17): 6350 - 6355.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K.-J. Sohn, S. A. Shah, S. Reid, M. Choi, J. Carrier, M. Comiskey, C. Terhorst, and Y.-I. Kim
Molecular Genetics of Ulcerative Colitis-associated Colon Cancer in the Interleukin 2- and {beta}2-Microglobulin-deficient Mouse
Cancer Res., September 1, 2001; 61(18): 6912 - 6917.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. A. Loeb
A Mutator Phenotype in Cancer
Cancer Res., April 1, 2001; 61(8): 3230 - 3239.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.