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Identification of a New Endoplasmic Reticulum-resident Protein Recognized by HLA-A24-restricted Tumor-infiltrating Lymphocytes of Lung Cancer¹

Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy [K. K., N. T., K. I., A. Y.], Departments of Immunology [S. G., K. T., K. I., A. Y.] and Gynecology [T. K.], Kurume University School of Medicine, Kurume 830-0011, Japan

To help clarify the molecular basis of tumor immunology in lung cancer, we have investigated antigens recognized by HLA-A24-restricted CTLs established from T cells infiltrating into lung adenocarcinoma and report a new gene encoding tumor epitopes recognized by the CTLs. This gene was located on chromosome 4q31.22 and encoded an unreported endoplasmic reticulum-resident protein with 412 deduced amino acids. This protein had a molecular mass of 46 kDa and was expressed in the majority of malignant cells and tissues tested, with the exception of T-cell leukemia cells, but was not expressed in a panel of normal cells and tissues, except in those of the testis, placenta, and fetal liver. Two peptides at positions 13–20 and 75–84 were recognized by the CTLs and had an ability to induce HLA-A24-restricted and tumor-specific CTLs in peripheral blood mononuclear cells of lung cancer patients. Thus, these peptides might be appropriate molecules for use in the specific immunotherapy of HLA-A24⁺ patients with lung and other cancers.

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