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Molecular Biology Laboratory, Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
Cyclin B1 is a key molecule for G2-M-phase transition during
the cell cycle and is overexpressed in various tumor types. However,
the expression status of cyclin B1 in lung cancer and its clinical
significance remain unknown. We used immunohistochemistry studies to
examine the expression of cyclin B1 in 77 non-small cell lung cancer
specimens from patients with histological stage I disease. All of the
patients underwent curative surgical treatment. The median length of
follow-up care is 8.2 years. High-level cyclin B1 expression (a cyclin
B1 labeling index 
15%) was observed in 17 of the 77
(22%) tumors. Patients whose tumors expressed a high level of cyclin
B1 had a significantly shorter survival time than patients whose tumors
expressed a low level of cyclin B1 (P = 0.02, log-rank test). Interestingly, overexpression of cyclin B1 was
more frequently observed in tumors with squamous cell histology than in
tumors with other histological cell types (P = 0.01, Fisher’s exact test). A subgroup analysis revealed that
cyclin B1 overexpression seems to be an adverse prognostic factor only
in patients with squamous cell carcinoma (SCC) of the lung
(P = 0.02, log-rank test). Our data
indicate that cyclin B1 may be dysregulated in non-small cell lung
cancer, particularly in the SCC subtype, and that a high level of
cyclin B1 expression may be a prognostic marker for patients with
early-stage SCC of the lung.
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