Cancer Research Landon Prizes for Basic and Translational Cancer Research Tumor Immunology: New Perspectives
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[Cancer Research 60, 4033-4036, August 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Prostate Cancer and Other Xenografts from Cells in Peripheral Blood of Patients1

Thomas G. Pretlow2, Stuart Schwartz, Joseph M. Giaconia, Alison L. Wright, Heather A. Grimm, Nancy L. Edgehouse, John R. Murphy, Sanford D. Markowitz, James M. Jamison, Jack L. Summers, Clive R. Hamlin, Gregory T. MacLennan, Martin I. Resnick, Theresa P. Pretlow and Cindylou F. Connell

Departments of Pathology [T. G. P., J. M. G., A. L. W., H. A. G., N. L. E., C. R. H., G. T. M., T. P. P.], Human Genetics [S. S.], Medicine [J. R. M., S. D. M., C. F. C.], and Urology [M. I. R.], Case Western Reserve University Medical Center, Cleveland, Ohio 44106, and Department of Urology, Summa Health System/Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 [J. M. J., J. L. S.]

Good models for the investigation of human prostate cancer are few. Cells from approximately 9.2–21 ml of peripheral blood from patients with metastatic prostate cancer or metastatic colon cancer were injected s.c. into nude mice. Prostate cancer from 2 of 11 patients and colon cancer from 1 of 3 patients were found to be growing as metastases in the lungs of the nude mice. To our knowledge, this is the first report of the formation of xenografts from carcinoma cells taken directly from the peripheral blood of patients. Expanding circulating cancer cells with this approach may have important translational applications including: (a) development of models of human cancers; and (b) sampling of cancers from specific patients for novel molecular and therapeutic approaches.




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