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[Cancer Research 60, 4324-4327, August 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Absence of Functional Lymphatics within a Murine Sarcoma: A Molecular and Functional Evaluation1

Anders J. Leu2, David A. Berk3, Athina Lymboussaki, Kari Alitalo and Rakesh K. Jain4

Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 [A. J. L., D. A. B., R. K. J.], and Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute, University of Helsinki, SF-00014 Helsinki, Finland [A. L., K. A.]

Despite a clinically recognized association between the lymphatics and metastasis, the biology of tumor-lymphatic interaction is not clearly understood. We report here that functional lymphatic capillaries are absent from the interior of a solid tumor, despite the presence within the tumor of the lymphangiogenic molecule vascular endothelial growth factor (VEGF)-C and endothelial cells bearing its receptor, VEGF receptor 3. Functional lymphatics, enlarged and VEGF receptor 3 positive, were detected in some tumors only at the tumor periphery (within 100 µm of the interface with normal tissue). We conclude that although lymphangiogenic factors are present, formation of functional lymphatic vessels is prevented, possibly due to collapse by the solid stress exerted by growing cancer cells.




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